Adverse prognostic value of MYBL2 overexpression and association with microRNA-30 family in acute myeloid leukemia patients.

abstract：:Recent studies have identified SOX11 as a novel diagnostic marker for mantle cell lymphoma (MCL). We quantified SOX11 by a truly mRNA specific qPCR assay in longitudinal peripheral blood samples from 20 patients and evidenced a close relationship of SOX11 expression and clinical status of the patients. In eight patien...

journal_title：Leukemia research

authors： Simonsen AT,Sørensen CD,Ebbesen LH,Bødker JS,Bentzen HH,Nyvold CG

更新日期：2014-08-01 00:00:00

abstract：:The hotspot c.7541_7542delCT NOTCH1 mutation has been proven to have a negative clinical impact in chronic lymphocytic leukemia (CLL). However, an optimal method for its detection has not yet been specified. The aim of our study was to examine the presence of the NOTCH1 mutation in CLL using three commonly used molecu...

journal_title：Leukemia research

authors： Vavrova E,Kantorova B,Vonkova B,Kabathova J,Skuhrova-Francova H,Diviskova E,Letocha O,Kotaskova J,Brychtova Y,Doubek M,Mayer J,Pospisilova S

更新日期：2017-09-01 00:00:00

abstract：:Inhibition of cyclooxygenase 2 (COX-2) by the selective COX-2 inhibitor celecoxib has been suggested as potentially useful for B-cell lymphoma therapy. However, additional pharmacological activities of celecoxib have been discovered and have challenged the notion that its antitumor effects are mediated primarily via t...

journal_title：Leukemia research

authors： Chen ST,Thomas S,Gaffney KJ,Louie SG,Petasis NA,Schönthal AH

更新日期：2010-02-01 00:00:00

abstract：:Leukemic bcr-abl positive dendritic cells (DCs) are likely to be present in vivo in chronic myelogenous leukemia (CML) patients, but no data are available on their functional qualities. We analyzed the circulating BDCA-1+ myeloid DC compartment in 15 chronic phase CML patients. Phenotypic features of CML DCs were comp...

journal_title：Leukemia research

authors： Orsini E,Calabrese E,Maggio R,Pasquale A,Nanni M,Trasarti S,Tafuri A,Guarini A,Foa R

更新日期：2006-07-01 00:00:00

abstract：:The aim of this study was to elucidate the pathologic sequence changes and associated clinical phenotypes in 9 new patients showing homozygosity for perforin gene among a total of 37 (24%) Turkish FHL families studied by linkage analysis. These 9 unrelated patients (5M/4F) were coming from consanguineous families and ...

journal_title：Leukemia research

authors： Okur H,Balta G,Akarsu N,Oner A,Patiroglu T,Bay A,Sayli T,Unal S,Gurgey A

更新日期：2008-06-01 00:00:00

abstract：:The association between seven polymorphisms in the genes hOCT1 and MDR1, encoding for imatinib transporter proteins, and the response to imatinib 400mg/daily was investigated in 65 patients newly diagnosed with chronic-phase chronic myeloid leukemia. The AA genotype at the rs6935207 hOCT1 polymorphic locus was not det...

journal_title：Leukemia research

authors： Maffioli M,Camós M,Gaya A,Hernández-Boluda JC,Alvarez-Larrán A,Domingo A,Granell M,Guillem V,Vallansot R,Costa D,Bellosillo B,Colomer D,Cervantes F

更新日期：2011-08-01 00:00:00

abstract：:N-Propyl-N-nitrosourea (PNU) was proved to be a strong leukemogen, which induces myelogenous leukemia or thymic lymphoma in rats. BUF/Mna rats and F344 rats were the strain most susceptible to thymic lymphomagenic activity of PNU. In addition, F1 rats between BUF/Mna and WKY rats were also susceptible to PNU-lymphomag...

journal_title：Leukemia research

authors： Ogiu T,Utsumi KR,Fukami H,Matsuyama M

更新日期：1988-01-01 00:00:00

abstract：:The usefulness of a new method to detect B-cell monoclonality named VR, which is a combination of the digestion with restriction enzymes and vectorette PCR, in aspiration biopsy-nucleic acid diagnosis (ABND) of thyroid malignant lymphoma was investigated. ABND was performed in 12 patients in whom malignant lymphoma wa...

journal_title：Leukemia research

authors： Takano T,Asahi S,Matsuzuka F,Hidaka Y,Yoshida H,Miyauchi A

更新日期：2008-01-01 00:00:00

abstract：:To evaluate the clinical usefulness of interleukin 2 (IL-2) on myelodysplastic syndromes (MDS), the serum IL-2 level, the effect of IL-2 on the proliferation of blasts, and the cell-mediated cytotoxic effect of IL-2 on blasts were examined in MDS patients. Of 18 patients, 2 patients had an increased serum IL-2 level. ...

journal_title：Leukemia research

authors： Ogata K,Yokose N,Ito T,An E,Dan K,Nomura T

更新日期：1993-02-01 00:00:00

abstract：:In previous studies, HL60 AML cells treated with tumor necrosis factor-alpha (TNF), interferon-gamma (IFN), and lipopolysaccharides (LPS) displayed decreased growth and viability, enhanced monocytic pathway differentiation and endogenous TNF release. Endogenous TNF release by LPS/TNF/IFN treated HL60 cells was postula...

journal_title：Leukemia research

authors： Treon SP,Anand B,Ulevitch R,Broitman SA

更新日期：1994-01-01 00:00:00

abstract：:Medullary dyserythropoiesis with reduced production of erythrocytes is an early and consistent feature of myelodysplastic syndromes (MDS). The mechanism underlying the disturbed red cell proliferation and maturation is presently unknown. In order to study the role of erythropoietic growth factors, we determined by rad...

journal_title：Leukemia research

authors： Aul C,Arning M,Runde V,Schneider W

更新日期：1991-01-01 00:00:00

abstract：:The prognosis of patients with advanced refractory lymphoma remains poor. We have carried out a Phase II study of continuous high dose intravenous recombinant interleukin 2 alone without LAK cells in this group of patients. Eight patients have so far been treated, 4 with non-Hodgkins lymphoma and 4 with Hodgkins disea...

journal_title：Leukemia research

authors： Lim SH,Worman CP,Callaghan T,Jewell A,Smith MP,Goldstone AH

更新日期：1991-01-01 00:00:00

abstract：:Early T-cell precursor-ALL (ETP-ALL) is a subtype of T-ALL with a poor prognosis in children. We analyzed ETP-ALL compared to conventional T-ALL/LBL in both adults and children to determine any differences in clinical outcomes, based on the following parameters: induction failure, relapse, and survival. Patients with ...

journal_title：Leukemia research

authors： Allen A,Sireci A,Colovai A,Pinkney K,Sulis M,Bhagat G,Alobeid B

更新日期：2013-09-01 00:00:00

abstract：:Promoter hypermethylation occurs early in leukemogenesis and seems to be associated with poor prognosis in acute lymphoblastic leukemia (ALL). The methylation status of the promoter region of six genes was analyzed in 71 children with ALL using methylation specific PCR (MSP). Calcitonin (CALCA) and E-cadherin (CDH1) w...

journal_title：Leukemia research

authors： Paixão VA,Vidal DO,Caballero OL,Vettore AL,Tone LG,Ribeiro KB,Lopes LF

更新日期：2006-07-01 00:00:00

abstract：:Beagle dogs were treated with recombinant human interleukin 2 (IL-2) 6 x 10(6) International Units (IU)/day for 7 consecutive days following conditioning with sublethal (200 cGy) or lethal (400 cGy) doses of high-dose rate whole body irradiation (WBI) and reconstitution with 2 x 10(8)/kg autologous bone marrow cells, ...

journal_title：Leukemia research

authors： Samuel S,Nagler A,Or R,Slavin S

更新日期：1992-10-01 00:00:00

abstract：:We have demonstrated that constitutive signal transducer and activator of transcription (STAT) 3 activity, observed in approximately 50% of acute myeloid leukemia (AML) cases, is associated with adverse treatment outcome. Constitutive STAT3 activation may result from the expression of oncogenic protein tyrosine kinase...

journal_title：Leukemia research

authors： Ghoshal Gupta S,Baumann H,Wetzler M

更新日期：2008-07-01 00:00:00

abstract：:Leukemic cells from 85 children with newly diagnosed precursor B-lineage ALL were tested for in vitro drug sensitivity to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. There was a significant correlation between MRD day 29 and in vitro sensitivity to prednisolone (p<0.001) and do...

journal_title：Leukemia research

authors： Lönnerholm G,Thörn I,Sundström C,Frost BM,Abrahamsson J,Behrendtz M,Heldrup J,Jacobsson S,Li A,Olofsson T,Porwit A,Söderhäll S,Larsson R,Forestier E

更新日期：2009-01-01 00:00:00

abstract：:Malignant B-1 cells derived from NZB mice, a murine model of chronic lymphocytic leukemia, produce significantly higher levels of IL-10 mRNA than normal B-1 or B cells. IL-10 may act as an autocrine growth factor for malignant B-1 cells. By addition of antisense oligodeoxynucleotides specific for IL-10 mRNA, we were a...

journal_title：Leukemia research

authors： Peng B,Mehta NH,Fernandes H,Chou CC,Raveché E

更新日期：1995-03-01 00:00:00

abstract：:The purpose of this study was to determine the relationship between platinum-DNA adducts in leukemic cells and the success of remission induction therapy in adult patients with acute nonlymphocytic leukemia (ANLL). Freshly isolated cells from pre-treatment bone marrow aspirates of 14 patients were incubated with cispl...

journal_title：Leukemia research

authors： Armstrong SG,Browman GP,Benger AM,Meyer RM,McKay KL,Singh G

更新日期：1994-09-01 00:00:00

abstract：:We describe here a unique case of therapy-related myelodysplastic syndrome (t-MDS) with inv(16)(p13q22) after autologous stem cell transplantation for lymphoma. The rare and smallest I type CBFbeta/MYH11 fusion transcript with a breakpoint at nucleotide 399 of CBFbeta and at nucleotide 2134 of MYH11 was detected in th...

journal_title：Leukemia research

authors： Yamamoto K,Nishikawa S,Minagawa K,Yakushijin K,Okamura A,Matsui T

更新日期：2006-03-01 00:00:00

abstract：:This study determined IgV(H) gene usage in 228 chronic lymphocytic leukaemia patients to investigate associations between gene usage and other biological or clinical characteristics. V(H)3-48 [N=8] and V(H)3-53 [N=4] gene rearrangements showed biased lambda light chain restriction and were predominantly found in femal...

journal_title：Leukemia research

authors： Matthews C,Catherwood MA,Morris TC,Alexander HD

更新日期：2007-02-01 00:00:00

abstract：:The PRAME gene encodes an antigen recognized by autologous T lymphocytes and is expressed in trophoblasts, testis and frequently in human solid cancers and acute leukemias, making it a candidate for immunotherapy and for detecting MRD. We demonstrate expression of PRAME by RT-PCR in the peripheral blood or bone marrow...

journal_title：Leukemia research

authors： Proto-Siqueira R,Falcão RP,de Souza CA,Ismael SJ,Zago MA

更新日期：2003-05-01 00:00:00

abstract：:MDS is primarily a disease of the elderly. Cases who give a history of exposure to X-rays, cytotoxic drugs or leukaemogenic chemicals may be younger. Many cases of MDS present because of an incidental blood count. The most prominent clinical features are those of anaemia, neutropenia, thrombocytopenia. Because haemopo...

journal_title：Leukemia research

authors： Hamblin T

更新日期：1992-01-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) plays a major role in the homeostasis of cellular protein. We demonstrate that each of the major hematologic diseases (AML, ALL, and MDS) has a specific and different plasma profile of UPS protein and enzymatic activities. While high levels of proteasome and ubiquitin proteins and...

journal_title：Leukemia research

authors： Ma W,Kantarjian H,Zhang X,Wang X,Estrov Z,O'Brien S,Albitar M

更新日期：2011-04-01 00:00:00

abstract：:The purpose of this study was to determine the sensitivity to merocyanine 540 (MC 540)-mediated photolysis of normal human hematopoietic progenitor cells and four leukemia cell lines (Daudi, Raji, K562 and HL-60). Late erythroid progenitors were the most sensitive normal cells. Early erythroid progenitors were of inte...

journal_title：Leukemia research

authors： Sieber F,Stuart RK,Rowley SD,Sharkis SJ,Sensenbrenner LL

更新日期：1987-01-01 00:00:00

abstract：:Nasal-type natural killer/T-cell (NK/T-cell) lymphomas are subtypes of non-Hodgkin's lymphoma (NHL), which are typically more clinically aggressive. There is, however relatively little understanding of nasal-type NK/T-cell lymphoma molecular pathogenesis. Thus, in this study we applied RNA sequencing to systematically...

journal_title：Leukemia research

authors： Zhang X,Zhao L,Li X,Wang X,Li L,Fu X,Sun Z,Li Z,Nan F,Chang Y,Zhang M

更新日期：2015-12-01 00:00:00

abstract：:Although recent advances in chemotherapy have markedly improved outcome of acute lymphoblastic leukemia (ALL), infantile ALL with MLL gene rearrangements (MLL+ALL) is refractory to chemotherapy. We have shown that specific cytokines FLT3 ligand and TGFβ1 both of which are produced from bone marrow stromal cells synerg...

journal_title：Leukemia research

authors： Ando N,Furuichi Y,Kasai S,Tamai M,Harama D,Kagami K,Abe M,Goi K,Inukai T,Sugita K

更新日期：2018-12-01 00:00:00

abstract：:Some peripheral blood clonogenic T-cells from patients with T-cell malignancies can generate colonies in methylcellulose in the absence of added growth factors or mitogen stimulation (T-CFCs). T-CFC from these patients were also able to form colonies in semi-solid media in the presence of added growth factors (T-CFCi)...

journal_title：Leukemia research

authors： Georgoulias V,Auclair H,Jasmin C

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:To analyze the frequency, clinical characteristics, and prognosis of IGH deletion in multiple myeloma (MM). METHODS:A total of 310 consecutive patients with multiple myeloma were analyzed. Among them 251 patients were newly diagnosed and 59 patients were previously treated, fluorescence in situ hybridization...

journal_title：Leukemia research

authors： He H,Fu W,Jiang H,Du J,Zhou L,Zhang C,Xi H,Li R,Hou J

更新日期：2015-05-01 00:00:00

abstract：:The treatment of acute leukemia is still challenging due in part to the development of resistance and relapse. This chemotherapeutics resistance is established by clonal selection of resistant variants of the cancer cells. Recently, a horizontal transfer of chemo-resistance among cancer cells via extracellular vesicle...

journal_title：Leukemia research

authors： Bouvy C,Wannez A,Laloy J,Chatelain C,Dogné JM

更新日期：2017-11-01 00:00:00