当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > V(H)3-48 and V(H)3-53, as well as V(H)3-21, gene rearrangements define unique subgroups in CLL and are associated with biased lambda light chain restriction, homologous LCDR3 sequences and poor prognosis.

V(H)3-48 and V(H)3-53, as well as V(H)3-21, gene rearrangements define unique subgroups in CLL and are associated with biased lambda light chain restriction, homologous LCDR3 sequences and poor prognosis.

Abstract：

:This study determined IgV(H) gene usage in 228 chronic lymphocytic leukaemia patients to investigate associations between gene usage and other biological or clinical characteristics. V(H)3-48 [N=8] and V(H)3-53 [N=4] gene rearrangements showed biased lambda light chain restriction and were predominantly found in female patients with short lymphocyte doubling time but without adverse prognosis cytogenetics. Overuse of V(L)3-21(Vlambda2-14) gene and highly homologous LCDR3 sequences were found in V(H)3-48 patients. V(H)3-21 gene usage [N=18, 7.9%] was associated with poor prognosis, overuse of V(L)3-21(Vlambda2-14) gene and highly homologous heavy- and light-chain CDR3 sequences, but was not associated with poor prognosis chromosomal aberrations.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Matthews C,Catherwood MA,Morris TC,Alexander HD

doi

10.1016/j.leukres.2006.03.028

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

231-4

issue

2

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(06)00141-X

journal_volume

31

pub_type

杂志文章

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