当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > The anti-angiogenesis agent, AG-013736, has minimal activity in elderly patients with poor prognosis acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

The anti-angiogenesis agent, AG-013736, has minimal activity in elderly patients with poor prognosis acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

Abstract：

:AG-013736 is an oral anti-angiogenesis agent with activity against a variety of receptor tyrosine kinases, including VEGFR-1, VEGFR-2, VEGFR-3, c-kit, and PDGFR-beta. A phase 2 study was conducted in patients with poor prognosis AML or MDS. Twelve patients (six AML; six MDS) were treated with AG-013736 at a dose of 10mg orally daily for a median of 56 days (range, 1-248 days). Median age was 80 years (range, 58-88 years). Grade 3 or 4 drug-related toxicities included hypertension (42%), mucositis (8%) and deep venous thrombosis (8%). No objective responses occurred; two patients with MDS had stable disease for 8.3 and 6.2 months, respectively. Bone marrow expression of VEGFR-1 and VEGFR-2 was observed in 11% and 0% of patients, respectively. Sustained decreases in soluble VEGFR-2 plasma levels with concomitant elevation in plasma VEGF and placental growth factor levels were obtained during the course of therapy with AG-013736. AG-01736 had minimal biologic or clinical activity in this elderly patient population.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Giles FJ,Bellamy WT,Estrov Z,O'Brien SM,Verstovsek S,Ravandi F,Beran M,Bycott P,Pithavala Y,Steinfeldt H,Reich SD,List AF,Yee KW

doi

10.1016/j.leukres.2005.10.024

keywords:

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

801-11

issue

7

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(05)00424-8

journal_volume

30

pub_type

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