Abstract:
:Forty-three patients were studied to determine whether light chain gene rearrangements may occur in hematopoietic cells not pertaining to the B-lineage. In only one patient, affected by T-cell lymphoblastic lymphoma, one kappa light chain allele was rearranged. Neither at the protein level nor at the RNA level the rearranged gene was expressed. These data confirm that, although rarely, kappa light chain gene rearrangements may occur in neoplastic T-cells. Furthermore, as in our patient Ig heavy chain genes retained a germline configuration, the present data demonstrate that kappa light chain gene rearrangements may occur regardless of Ig heavy chain gene arrangement.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Moretti L,Mariano MT,Donelli A,Montagnani G,Sarti M,Grantini M,Di Prisco U,Torelli U,Narni Fdoi
10.1016/0145-2126(91)90145-jsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
59-63issue
1eissn
0145-2126issn
1873-5835pii
0145-2126(91)90145-Jjournal_volume
15pub_type
杂志文章abstract::Five patients from the Kyushu area in Japan with adult T-cell leukaemia (ATL) refractory to conventional chemotherapeutic agents were treated with 5 mg/m2 of the adenosine deaminase inhibitor, 2'-deoxycoformycin (DCF), intravenously (i.v.) for 3 consecutive days, followed by 5 mg/m2 i.v. weekly. Two patients showed a ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(86)90251-1
更新日期:1986-01-01 00:00:00
abstract::Epstein-Barr virus (EBV) can induce a broad spectrum of hematological diseases, especially in immune deficient patients. We assayed for receptor for EBV (EBVR) using fluoresceinated viral particles on 44 human hematopoietic cell lines derived from patients with T, B, and non-T, non-B acute lymphocytic leukemia (ALL), ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(85)90085-2
更新日期:1985-01-01 00:00:00
abstract::Little information is available about the risk factors and means to improve the survival rate of acute leukemia in a rare but often fatal complication after liver transplantation (LT). We report the development of AML-M2 in one of the 764 patients who underwent liver transplantation at our center, and review the liter...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.03.035
更新日期:2009-10-01 00:00:00
abstract::Acute myeloid leukemia is an aggressive disease that arises from clonal expansion of malignant hematopoietic precursor cells of the bone marrow. Deletions on the long arm of chromosome 9 (del(9q)) are observed in 2% of acute myeloid leukemia patients. Our deletion analysis in a cohort of 31 del(9q) acute myeloid leuke...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2018.11.007
更新日期:2019-01-01 00:00:00
abstract::Although the earliest sites of hematopoietic cell and endothelial cell differentiation in the yolk sac blood islands were identified about 100 years ago, cells with hemangioblast properties have not yet been identified in vivo. Endothelial cells differentiate from angioblasts in the embryo and from endothelial progeni...
journal_title:Leukemia research
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.leukres.2006.10.014
更新日期:2007-04-01 00:00:00
abstract::It has been suggested that acidic isoferritins play a major role in the regulation of human granulocyte-macrophage (CFU-GM) proliferation. Such regulatory isoferritins are said to occur in some human tissues including both leukaemic and normal leucocytes, and certain established cell lines. They are glycosylated and b...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(84)90065-1
更新日期:1984-01-01 00:00:00
abstract::Assessment of treatment response in acute leukemia is routinely performed after therapy via bone marrow biopsy. We investigated the use of positron emission tomography (PET) for early assessment of treatment response in patients with acute myeloid leukemia (AML), using the proliferation marker 3'-deoxy-3'-[(18)F]fluor...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2010.06.010
更新日期:2011-03-01 00:00:00
abstract::We analysed the optimal conditions for autologous bone marrow purging using complement binding monoclonal antibodies (mAbs). Twelve mAbs belonging to four clusters (CD9, CD10, CD19, CD24), alone or combined were evaluated by using direct cytotoxicity and clonogenic assays. We observed the following data: (1) optimal c...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90117-2
更新日期:1987-01-01 00:00:00
abstract::Using the human erythroleukaemic cell line K562 cl.6 and its daunorubicin-resistant subline K/DAU600, and the human T-lymphoblastic leukaemic cell line CCRF-CEM and its vinblastine-resistant subline CEM/VLB100, we have shown that the drug-resistant cell lines were more sensitive to cytotoxicity induced by tumour necro...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(94)00149-5
更新日期:1995-03-01 00:00:00
abstract::To clarify whether expression of the programmed cell death 5 (PDCD5) gene in leukemic cells is abnormal, real-time quantitative reverse transcription polymerase chain reaction (RQ-RT-PCR) was used to examine its expression in marrow cells from leukemia patients. We found lower PDCD5 in both AML and CML marrow cells th...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2005.12.028
更新日期:2006-09-01 00:00:00
abstract::We established a plasmacytoid dendritic cell (pDC) line (PMDC05) from leukemia cells of pDC leukemia. PMDC05 cells were positive for CD4, CD56, CD33, HLA-DR, CD123 (IL-3Ralpha) and CD86 in the absence of lineage markers. mRNA of TLR1, TLR2, TLR4, TLR7 and TLR9 was clearly expressed and among these TLRs, TLR7 was promi...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.03.047
更新日期:2009-09-01 00:00:00
abstract::The technology of array comparative genomic hybridization (array-CGH/aCGH) enabled the identification of novel genomic aberrations in chronic lymphocytic leukemia (CLL) including the monoallelic and biallelic deletions affecting 22q11 locus. In contrast to previous publications, we hypothesized that the described 22q1...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.03.018
更新日期:2013-07-01 00:00:00
abstract::To further understand the role of XIAP in acute myeloid leukemia (AML), we suppressed XIAP expression by antisense oligonucleotides and determined the effect on gene expression profiles and biological pathways. XIAP inhibition upregulated expression of proteasome genes in a manner similar to the proteasome inhibitor b...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.04.018
更新日期:2013-08-01 00:00:00
abstract::Delta retrovirus-mediated leukemogenesis is dependent on the oncogenic potential of Tax. It is not clear, however, whether Tax-specific immune responses play a role in leukemia onset and progression. Using the BLV-associated leukemia model in sheep, we found that Tax-specific cytotoxic responses induced by DNA immuniz...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2010.06.003
更新日期:2010-12-01 00:00:00
abstract::Incidence and outcomes of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) are not well established at the population level, especially since the widespread use of immunophenotyping. We studied the epidemiology of CLL in Manitoba (Canada) by combining data from a centralized flow cytometry facility and th...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.06.013
更新日期:2009-11-01 00:00:00
abstract::Standard chemotherapic approach for MZL is missing. We are presenting our monocenter experience with 2CdA+/-rituximab. Patients received 2CdA, 5mg/m(2), weekly, for 6 weeks. Patients receiving rituximab underwent to antibody administration in association with 2CdA, or after the end of chemotherapy. Global ORR was 89.3...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.leukres.2009.04.003
更新日期:2010-02-01 00:00:00
abstract::Malignant plasma cells exert osteoclast-like activity in vitro. We investigated the function of the calcitonin (CT) receptor (R) on myeloma cells from patients and in myeloma cell lines. Primary myeloma cells expressed high CTR levels whereas the cell lines uniformly exposed the CTR-2 variant expressed by osteoclasts....
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.07.009
更新日期:2008-04-01 00:00:00
abstract::Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B (NF-kappaB), which is a target molecule of these kin...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2005.01.008
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal disorders, with very different prognosis in given individuals; age and comorbidities are emerging as relevant patient-related factors influencing clinical outcome in MDS. Our aim was to evaluate the impact of age, comorbidities and disease s...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2015.05.007
更新日期:2015-08-01 00:00:00
abstract::The purpose of this study was to determine the relationship between platinum-DNA adducts in leukemic cells and the success of remission induction therapy in adult patients with acute nonlymphocytic leukemia (ANLL). Freshly isolated cells from pre-treatment bone marrow aspirates of 14 patients were incubated with cispl...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章
doi:10.1016/0145-2126(94)90064-7
更新日期:1994-09-01 00:00:00
abstract::We investigated the role of Src family kinases (SFKs) in the regulation of STAT activation in myeloid leukemia cells. Two of 6 AML cell lines displayed constitutive STAT5 activation, whereas four cell lines had constitutive SFK activity. Treatment with the SFK inhibitors suppressed STAT5 activation and decreased viabi...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.11.032
更新日期:2008-06-01 00:00:00
abstract::Blastic transformation of myeloproliferative neoplasms (MPN) is still poorly understood. We describe a cohort of 23 Roswell Park Cancer Institute (RPCI) patients and 89 additional cases from the English literature for whom biologic features were described. We initially compared our 23 patients to the 89 cases from the...
journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/j.leukres.2010.07.031
更新日期:2011-05-01 00:00:00
abstract::Pyothorax-associated lymphoma (PAL) is a representative form of diffuse large B-cell lymphoma associated with chronic inflammation, in which the Epstein-Barr virus (EBV) genome is consistently detectable in the lymphoma cells of all PAL cases. Cell lines and animal models would be useful for understanding better this ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.07.033
更新日期:2013-11-01 00:00:00
abstract::Useful prognostic markers for patients with diffuse large B cell lymphoma (DLBCL) have been reported. To identify which biomarker best predicts the prognosis of patients with DLBCL, we performed a retrospective study that included 319 DLBCL patients who had received rituximab, cyclophosphamide, doxorubicin, vincristin...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2015.08.016
更新日期:2015-08-29 00:00:00
abstract::The in-vitro effects of deoxycoformycin (dCF) on dATP, NAD, ATP and DNA strand breaks have been evaluated in the cells from 42 patients with various types of chronic lymphoid leukemia. These included 18 with B-cell chronic lymphoid leukemias of different types (BCL); 10 with hairy cell leukemia (HCL) and 14 with T-cel...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90140-8
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:To analyze the frequency, clinical characteristics, and prognosis of IGH deletion in multiple myeloma (MM). METHODS:A total of 310 consecutive patients with multiple myeloma were analyzed. Among them 251 patients were newly diagnosed and 59 patients were previously treated, fluorescence in situ hybridization...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2015.02.010
更新日期:2015-05-01 00:00:00
abstract::In 141 adult patients with diagnosis of acute myeloid leukemia the overall expression and intensity of expression of CD34 antigen on leukemic cells was investigated. Myeloid blasts were tested by applying direct immunofluorescence staining using anti-CD34 fluorescein monoclonal antibody in flow cytometry. CD34 antigen...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(97)00015-5
更新日期:1997-07-01 00:00:00
abstract::Chronic myelogenous leukemia (CML) and 25% of adult onset acute lymphoblastic leukemia (ALL) are associated with the expression of Bcr-Abl, a constitutively activated protein tyrosine kinase. Bcr-Abl associated leukemias are characterized by a high degree of chromosomal and genomic instability. It is unclear if the ph...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00181-3
更新日期:2002-11-01 00:00:00
abstract::Two white European males are reported with adult T-cell leukemia (ATL), a disease first described in Japan, but recently also in the U.K. and U.S.A. Both patients presented with lymphadenopathy, but without a mediastinal mass. In addition, one patient had skin infiltrates and the other had hepatosplenomegaly. Morpholo...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(83)90055-3
更新日期:1983-01-01 00:00:00
abstract::Recent studies indicate that lipid metabolic changes affect the survival of multiple myeloma (MM) cells. Time-of-flight secondary ion mass spectrometry (TOF-SIMS), an imaging mass spectrometry technique, is used to visualize the subcellular distribution of biomolecules including lipids. We therefore applied this metho...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2015.02.011
更新日期:2015-06-01 00:00:00