Abstract：
:We analysed the optimal conditions for autologous bone marrow purging using complement binding monoclonal antibodies (mAbs). Twelve mAbs belonging to four clusters (CD9, CD10, CD19, CD24), alone or combined were evaluated by using direct cytotoxicity and clonogenic assays. We observed the following data: (1) optimal cytotoxicity was reached with doses of 1-10 micrograms mAbs for 10(7) cells, (2) the concentration of the cell suspension had to be below 3 X 10(7)/ml, (3) combinations of mAbs were more effective than a single mAb treatment, (4) in the case of an IgM isotype, there seems to be a clear dissociation between the amount needed for optimal toxicity and that for antigenic saturation measured by cytofluorometry.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Racadot E,Herve P,Lamy B,Peters Adoi
10.1016/0145-2126(87)90117-2subject
Has Abstractpub_date
1987-01-01 00:00:00pages
987-94issue
11eissn
0145-2126issn
1873-5835journal_volume
11pub_type
杂志文章abstract：:Regulation of pluripotent stem cell (CFU-S) proliferation kinetics by humoral factors is now well documented. However, the mechanism of choice of CFU-S differentiation pathways is still a controversial issue. We suggest that long-range humoral factors (pluripoietins) are capable of preferentially channelling CFU-S tow...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(84)90041-9
更新日期：1984-01-01 00:00:00
abstract：:This study examines the occurrence, subtype and possible significance of haemopoietic inhibitory T cells (HIT cells) in patients with myelodysplasia (n = 21), acute myeloblastic leukaemia (n = 8) and in normal subjects (n = 13) using an autostimulary CFU-GM stem cell assay. HIT cells were detected when colony numbers ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90028-r
更新日期：1991-01-01 00:00:00
abstract：:We investigated the possible influence of recombinant (r) sIL-6R on the growth of three IL-6 non-responsive or weakly IL-6 responsive long-term myeloma cell lines. The three cell lines chosen for the study (U266, L363 and Fravel) all expressed gp130 but differed in their expression of IL-6R and IL-6. mRNA analysis by ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(95)00077-1
更新日期：1996-04-01 00:00:00
abstract：:The term "refractory anemia" was used in 1937 by Cornelius Parker Rhoads to describe patients whose anemia did not improve after treatment with liver extract or iron salts, and this term has been used to denote patients with certain subtypes of myelodysplastic syndromes (MDS) since the 1976 and 1982 French-American-Br...
journal_title：Leukemia research
pub_type： 历史文章,杂志文章
doi：10.1016/j.leukres.2016.10.007
更新日期：2016-12-01 00:00:00
abstract：:Quantitative differences in HLe-1 expression were studied on normal lymphocytes and lymphoblasts of patients with acute lymphoblastic leukemia (ALL). A relationship was found between quantitative antigen expression and therapeutic outcome. Alterations in fluorescence intensity (FI) were demonstrated using quantitative...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90110-x
更新日期：1987-01-01 00:00:00
abstract：:Dequalinium (DQA) has been proposed as a selective antitumoral agent due to its preferential accumulation in mitochondria of cancer cells. Our aim was a better understanding of DQA cytotoxicity. DQA-induced NB4 and K562 cell alterations are initiated within the first 30 min of treatment at a high DQA concentration wit...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.11.018
更新日期：2007-07-01 00:00:00
abstract：:DNAs from chronic granulocytic leukaemia (CGL) and chronic myelomonocytic leukaemia (CMML) were assayed for transforming genes by transfection into NIH 3T3 cells. Foci DNA was tagged with a geneticin-resistance cosmid, then followed through a drug selection and tumorigenicity assay. Activated Ha-ras genes, with point ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(88)90033-1
更新日期：1988-01-01 00:00:00
abstract：:Two AML patients, whose leukemic clonogenic cells totally reacted to the anti-lactofucopentaose III S4-7 monoclonal antibody (MoAb), underwent autologous bone marrow transplantation, in first complete remission, after in-vitro purging with S4-7 MoAb and complement. After ablative chemotherapy (BAVC regimen) and reinfu...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90050-6
更新日期：1987-01-01 00:00:00
abstract：:The MTT cell viability assay is widely used in determining drug sensitivity profiles for patients with hematological malignancies and in primary screening of potential chemotherapeutic drugs. Because the multidrug resistance (MDR) phenotype is associated with these malignancies, and since many vital dyes are effluxed ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(92)90114-m
更新日期：1992-12-01 00:00:00
abstract：:Hyperdiploid and non-hyperdiploid multiple myeloma represents distinct biological entities characterized by different patterns of genetic changes. We sought to determine whether ploidy category (non-hyperdiploid versus hyperdiploid) remains stable over time from diagnosis to progression. Of the 43 patients studied (39...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.leukres.2005.07.004
更新日期：2006-03-01 00:00:00
abstract：:Bone marrow cells from 109 patients (median age 60) with newly diagnosed acute myeloid leukaemia (AML) were prospectively immunophenotyped (IP) and the prognostic value of monoclonal antibody (MAB) reactivities was analysed to detect differences in complete remission rates and survival, not only between groups of MAB ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90071-z
更新日期：1991-01-01 00:00:00
abstract：:The development of the leukemia-lymphoma complex was studied in AKR/J (H-2k) mice using flow cytometry and staining with acridine orange. Investigation of cytokinetics and of cellular RNA content showed that during the neonatal period all mice had a significant increase of S phase cells in the thymus, bone marrow, lym...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(85)90158-4
更新日期：1985-01-01 00:00:00
abstract：:Osteopontin (OPN) is a cytokine that contributes substantially to the growth and metastasis in a wide spectrum of malignancies. We report here that OPN gene is transactivated by Tax protein of human T-cell leukemia virus type 1 (HTLV-1). Northern blot showed enhanced OPN gene expression in cells stably expressing Tax....
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.08.028
更新日期：2010-06-01 00:00:00
abstract：:miR-16, a miRNA involved in cell proliferation and apoptosis regulation, may interfere with either oncogenic or tumor-suppressor pathways and is implicated in leukemogenesis. We then explored its expression in 93 childhood acute lymphoblastic leukemia (ALL) cases. A high miR-16 expression was associated with hyperleuk...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2008.12.015
更新日期：2009-09-01 00:00:00
abstract：:Mantle cell lymphoma (MCL) an incurable B-cell, non-Hodgkin lymphoma (NHL) urgently requires new treatments. We assessed reovirus mediated oncolysis in a panel of human MCL cell lines. In vitro, we found the cytopathic effect of reovirus infection ranged from high to very limited and correlated with levels of Ras acti...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.05.020
更新日期：2010-01-01 00:00:00
abstract：:The etiology of LGL leukemia is not known; however, we recently detected HTLV-II in a patient with LGL leukemia. In this study, we found that sera from 6 of 28 patients with LGL leukemia were positive for HTLV-I/II using a whole virus ELISA; moreover, the ELISA-negative sera were near the positive cut-off value. There...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(94)90078-7
更新日期：1994-06-01 00:00:00
abstract：:Heterogeneity for 5'nucleotidase has been demonstrated in chronic lymphocytic leukemia [12]. The enzyme is not detectable in the lymphocytes from the majority of patients with this disorder, but normal and even supranormal levels are found in some cases [17]. In the present studies, the properties of this ecto-nucleot...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(82)90026-1
更新日期：1982-01-01 00:00:00
abstract：:In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MD...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.10.012
更新日期：2007-04-01 00:00:00
abstract：:The immunologic phenotype of the lymphocytes of 100 patients with chronic lymphocytic leukaemia (CLL) was investigated. Peripheral blood lymphocytes (PBL) were examined in all cases; in 46 patients with lymphadenopathy, a lymph node was biopsied and the histologic and immunologic patterns were assessed: 24 had a lymph...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90063-4
更新日期：1987-01-01 00:00:00
abstract：:This study uses single cell network profiling (SCNP) to characterize biological pathways associated with in vitro resistance or sensitivity to chemotherapeutics commonly used in acute myeloid leukemia (AML) (i.e. cytarabine/daunorubicin, gemtuzumab ozogamicin (GO), decitabine, azacitidine, clofarabine). Simultaneous m...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.02.022
更新日期：2012-07-01 00:00:00
abstract：:Concern has been expressed recently about apparent increases in the incidence of leukaemia amongst young people living in certain geographical areas. We analysed the incidence of childhood leukaemia in South-East Scotland (excluding North-East Fife) from 1970 to 1984. There was a significant geographical variation in ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(86)90091-3
更新日期：1986-01-01 00:00:00
abstract：:The WHO classification of hematological malignancies includes 5q-syndrome as a separate category within myelodysplastic syndromes (MDS). Clinically, patients with 5q-syndrome have a milder disease than patients with other MDS. The basis for this difference is not known. Identifying 5q-syndrome can be difficult because...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(02)00039-5
更新日期：2002-10-01 00:00:00
abstract：:We investigated the transcript levels of genes STAT1, STAT3, STAT5A and STAT5B in the diagnostic samples of childhood ALL patients and compared them to those of healthy controls in order to characterize STAT gene expression in childhood ALL. As compared to controls, ALL patients exhibit markedly decreased transcript l...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2015.09.004
更新日期：2015-09-11 00:00:00
abstract：BACKGROUND/AIMS:Multiple myeloma (MM) is caused by proliferation of clonal plasma cells (cPCs) in bone marrow (BM), associated with numerical and functional defects in immune subsets. An impairment of B cell compartment is involved in onset/progression of the disease. METHODS:By flow cytometry, we studied distribution...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2016.08.008
更新日期：2016-10-01 00:00:00
abstract：:Clinical features of myelodysplastic syndromes (MDS) could be influenced by many factors, such as disease intrinsic factors (e.g., morphologic, cytogenetic, molecular), extrinsic factors (e.g, management, environment), and ethnicity. Several previous studies have suggested such differences between Asian and European/U...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.leukres.2018.08.022
更新日期：2018-10-01 00:00:00
abstract：:Immunophenotypic classification of the acute leukemias (AcL) is of well documented value in those of lymphoid or uncertain origin and of increasing importance in those of nonlymphoid origin. Most of these studies have been performed on viable cell suspensions. To study the efficacy of a simpler immunohistochemical app...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90080-4
更新日期：1987-01-01 00:00:00
abstract：:CFW/D mice injected neonatally with a type B retrovirus, (DMBA-LV), rapidly develop thymic lymphomas. The present study examined simultaneously the karyotype and the expression of surface antigens on thymocytes from DMBA-LV treated mice at 28, 35 and 42 days of age during the development of lymphomas, and of cells fro...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(89)90122-7
更新日期：1989-01-01 00:00:00
abstract：:Despite the high effectiveness of various P-glycoprotein (P-gp) modulating substances in vitro their clinical value e.g. for combination treatment of acute myelogenous leukemias (AML) remains still unclear. This might be explainable by recent findings that other factors than P-gp (e.g. the multidrug resistance associa...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(98)00192-1
更新日期：1999-05-01 00:00:00
abstract：:Cell line PER-423 was derived from the cells of a patient with an immature acute T-lymphoblastic leukaemia and the growth of this human cell line is strictly dependent on interleukin-2 (IL-2). PER-423 cells express the p75 (beta) subunit of the IL-2 receptor (IL-2R beta), while the p55 chain (IL-2R alpha) is not detec...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(93)90141-7
更新日期：1993-01-01 00:00:00
abstract：:Radiotherapy (RT)is considered the treatment of choice in patients with Extra-nodal marginal zone lymphoma (EMZL) at early stage, but the presence of late toxicities has been limited the acceptance. Recently, low doses of RT LDR) (2 x 2 Gy) and the use of limited fields has been observed that retain the efficacy but e...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.leukres.2020.106443
更新日期：2020-11-01 00:00:00
