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Assessing signaling pathways associated with in vitro resistance to cytotoxic agents in AML.

Abstract：

:This study uses single cell network profiling (SCNP) to characterize biological pathways associated with in vitro resistance or sensitivity to chemotherapeutics commonly used in acute myeloid leukemia (AML) (i.e. cytarabine/daunorubicin, gemtuzumab ozogamicin (GO), decitabine, azacitidine, clofarabine). Simultaneous measurements at the single cell level of changes in DNA damage, apoptosis and signaling pathway responses in AML blasts incubated in vitro with the above drugs showed distinct profiles for each sample and mechanistically different profiles between distinct classes of agents. Studies are ongoing to assess the clinical predictive value of these findings.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Rosen DB,Cordeiro JA,Cohen A,Lacayo N,Hogge D,Hawtin RE,Cesano A

doi

10.1016/j.leukres.2012.02.022

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

900-4

issue

7

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(12)00094-X

journal_volume

36

pub_type

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