Abstract:
:Two AML patients, whose leukemic clonogenic cells totally reacted to the anti-lactofucopentaose III S4-7 monoclonal antibody (MoAb), underwent autologous bone marrow transplantation, in first complete remission, after in-vitro purging with S4-7 MoAb and complement. After ablative chemotherapy (BAVC regimen) and reinfusion of S4-7 purged cells, regeneration of marrow cells occurred with prompt recovery of granulopoiesis and erythropoiesis. A more delayed platelet recovery was observed. The two patients are in complete remission at 20 and 11 months from ABMT. The results indicate that immunologic purging with S4-7 MoAb is safe and suitable for selected AML patients undergoing ABMT.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Ferrero D,De Fabritiis P,Amadori S,De Felice L,Gallo E,Meloni G,Pregno P,Pulsoni A,Simone F,Tarella Cdoi
10.1016/0145-2126(87)90050-6subject
Has Abstract,Author List Incompletepub_date
1987-01-01 00:00:00pages
265-72issue
3eissn
0145-2126issn
1873-5835journal_volume
11pub_type
杂志文章abstract::Treatment failure of patients with acute myelogenous leukemia (AML) is frequently due to the development of multidrug resistance phenotype blasts. We have expressed a fusion protein consisting of human granulocyte-macrophage colony stimulating factor (GMCSF) fused to the N-terminus of a lectin-deficient ricin toxin B ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(97)00043-x
更新日期:1997-07-01 00:00:00
abstract::Acute monocytic leukemia (M5) is a subtype of acute myeloid leukemia (AML) with two distinct morphologic subcategories, M5a and M5b. We compared the immunophenotype, cytogenetics and clinical outcome of AML M5 with non-M5 AML and also compared M5a with M5b. One hundred and twelve M5 (76 M5a, 36 M5b) and 726 non-M5 cas...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.06.019
更新日期:2008-02-01 00:00:00
abstract::The results of allogeneic marrow transplantation in 75 patients with acute lymphoblastic leukemia and 63 patients with acute non-lymphoblastic leukemia in relapse are reviewed. The effects of various chemotherapeutic regimens added to the basic regimen of cyclophosphamide (Cy) 60 mg/kg given on each of two successive ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(82)90101-1
更新日期:1982-01-01 00:00:00
abstract::Feulgen-DNA cytophotometry and 3H-thymidine autoradiography were used to evaluate therapeutic cytapheresis effects on cell cycle distributions of peripheral blood leukemic cells in 15 acute leukemia, 5 CML and 8 CLL patients and of bone marrow erythroblasts in 18 PV patients. Both individual cytapheresis procedures an...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90186-x
更新日期:1987-01-01 00:00:00
abstract::Mutations in Janus kinase 2 (JAK2) are implicated in the pathogenesis of Philadelphia-chromosome negative myeloproliferative neoplasms, including primary myelofibrosis, polycythemia vera, and essential thrombocythemia. Gandotinib (LY2784544), a potent inhibitor of JAK2 activity, shows increased potency for the JAK2V61...
journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.leukres.2017.08.010
更新日期:2017-10-01 00:00:00
abstract::Although biological and clinical features differ between B-lineage acute lymphoblastic leukemia (ALL) and T-lineage ALL (T-ALL), there have been few reports that focused on the prognosis for T-ALL in adults, primarily due to its rarity. Here, we studied the long-term outcomes and prognostic factors specific for adult ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.08.004
更新日期:2007-07-01 00:00:00
abstract::Helix-loop-helix (HLH) transcription factors are involved in cellular growth and differentiation. The Id (inhibitor of DNA binding and differentiation) HLH proteins, in a dominantly negative fashion, regulate transcriptional activities of basic HLH proteins. We examined by northern hybridization the expression of Id2 ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00084-4
更新日期:1995-12-01 00:00:00
abstract::Despite the high effectiveness of various P-glycoprotein (P-gp) modulating substances in vitro their clinical value e.g. for combination treatment of acute myelogenous leukemias (AML) remains still unclear. This might be explainable by recent findings that other factors than P-gp (e.g. the multidrug resistance associa...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(98)00192-1
更新日期:1999-05-01 00:00:00
abstract::Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in folate metabolism and DNA methylation. Studies on MTHFR polymorphism in leukemia have largely focused on the protective role of MTHFR polymorphism in acute lymphoblastic leukemia (ALL). We evaluated the C677T and A1298C polymorphisms using the TaqMan...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.10.016
更新日期:2007-09-01 00:00:00
abstract::Anti-MY9 is an IgG2b murine monoclonal antibody selected for reactivity with immature normal human myeloid cells. The MY9 antigen is expressed by blasts, promyelocytes and myelocytes in the bone marrow, and by monocytes in the peripheral blood. Erythrocytes, lymphocytes and platelets are MY9 negative. All myeloid colo...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(84)90001-8
更新日期:1984-01-01 00:00:00
abstract::The serum levels of interleukin 6 (IL6) are known to be elevated in two diseases of the elderly age, myelodysplastic syndrome (MDS) and multiple myeloma (MM). Authors suppose that one of the possible causes of this elevation could be a difference between these patients and healthy subjects in the frequency of polymorp...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.03.009
更新日期:2009-11-01 00:00:00
abstract::To determine the role of cell-mediated immunity (CMI) to cytomegalovirus (CMV) in leukemic children after CMV infection, CMI to CMV antigen was studied using CMV-specific lymphocyte blastogenic responses (LBR) and interferon (IFN) production. Four children, who continuously secreted CMV in urine more than 2 years afte...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(94)90086-8
更新日期:1994-07-01 00:00:00
abstract::Human promyelocytic leukemia cells (HL-60) mature into functional granulocytes in response to in vitro treatment with several classes of chemical agents. Compounds that increase intracellular adenosine 3':5' -cyclic monophosphate induce a modified program of maturation in which the cells demonstrate functional propert...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(85)90311-x
更新日期:1985-01-01 00:00:00
abstract::Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm of the hematopoietic stem cell characterized by presence of the oncoprotein BCR-ABL1, which have constitutive tyrosine kinase activity. BCR-ABL1 activation induces aurora kinase A (AURKA) and aurora kinase B (AURKB) expression, which are serine-thr...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2016.06.011
更新日期:2016-09-01 00:00:00
abstract::Vinorelbine chemotherapy with G-CSF stimulation is the standard mobilization regimen in Switzerland for multiple myeloma patients. However, with the increasing use of bortezomib during induction treatment, adding the neurotoxic compound vinorelbine for mobilization may aggravate bortezomib-induced polyneuropathy. In t...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2015.03.015
更新日期:2015-07-01 00:00:00
abstract::The Philadelphia (Ph1) chromosome is a specific structural abnormality in which the abl oncogene is activated due to the formation of the novel chimeric gene, bcr/abl. To investigate the clinicopathological role of bcr/abl in Ph1-positive chronic myelogenous leukaemia (CML), we studied the clonal origin of haematopoie...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(92)90139-x
更新日期:1992-01-01 00:00:00
abstract::CD200 is a relatively ubiquitously expressed molecule that plays a role in cancer immune evasion through interaction with its receptors. High expression levels of CD200 have been described in different human malignancies. For example, CD200 has been shown to be targeted after RAS/RAF/MEK/ERK activation in melanoma. He...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.08.006
更新日期:2013-12-01 00:00:00
abstract::When spleen cells of mice grafted with STIL-3 C5 cells, a leukemic T-cell line producing IL-3, are cultured in vitro, a high IL-3 activity is detectable in the culture supernatant. However, when bone marrow cells of the same grafted mice are cultured under similar conditions, hardly any IL-3 activity is detectable. To...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(92)90035-6
更新日期:1992-09-01 00:00:00
abstract::Of 597 cases of acute leukaemia in adults (greater than 16 years) seen at St. Bartholomew's Hospital, London, between May 1973 and January 1982, 412 were diagnosed as AML, 103 as ALL and 58 as Philadelphia chromosome positive blast crisis of CML (13 presenting as acute leukaemia and 45 having a prior chronic phase). T...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(83)90067-x
更新日期:1983-01-01 00:00:00
abstract::Pro-apoptotic signalling upon toll-like receptor (TLR) stimulation in myeloid cells is normally antagonized by the simultaneous activation of anti-apoptotic pathways. We have previously reported that IFN-alpha can sensitize human monocytes to apoptosis induction by lipopolysaccharide (LPS). Based on these results we i...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.05.001
更新日期:2007-12-01 00:00:00
abstract::Although there has been much progress in the treatment of acute lymphoblastic leukemia (ALL), decreased sensitivity to chemotherapy remains a significant issue. Recent studies have shown how interactions with the bone marrow microenvironment can protect ALL cells from chemotherapy and allow for the persistence of the ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.01.030
更新日期:2017-05-01 00:00:00
abstract::The expression of various proto-oncogenes in primary culture of lymphocytes from peripheral blood of bovine with chronic lymphocytic leukemia (CLL) was studied. Cellular proto-oncogenes encode proteins that propagate growth, differentiation or apoptosis signals from cell membrane to nucleus. The proliferation and diff...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(97)00128-8
更新日期:1998-02-01 00:00:00
abstract::Despite high rates of hematologic and cytogenetic responses to imatinib therapy, the emergence of resistance to imatinib has been recognized as a major problem in the treatment of Ph-positive leukemia. The high frequency of BCR-ABL mutations and amplifications represents the high degree of heterogeneity in patients wi...
journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/j.leukres.2003.10.007
更新日期:2004-05-01 00:00:00
abstract::In-vitro infection of normal human lymphocytes with HTLV-I (human T-cell lymphotropic retrovirus type I) has been carried out to study the target cell specificity and the kinetics of infection. Cord blood (CBL) and adult peripheral blood lymphocytes (PBL) have been co-cultivated with irradiated HTLV-I donor cells (MT2...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(86)90056-1
更新日期:1986-01-01 00:00:00
abstract::Patients with FLT3-ITD mutated (FLT3-ITD+) Acute Myeloid Leukemia (AML), have frequently relapsed or refractory disease and FLT3-ITD+ inhibitors have limited efficacy. Rho kinases (ROCK) are constitutively activated by FLT3-ITD+ in AML via PI3 kinase and Rho GTPase. Upon activation by ROCK, LIM kinases (LIMK) inactiva...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2020.106490
更新日期:2020-12-13 00:00:00
abstract::Immunoglobulin gene rearrangements can be used as genetic markers of clonality in the study of B-cell populations [4]. We have therefore analysed the structure and expression of heavy and light chain immunoglobulin genes in lymphocytes of a patient with chronic lymphocytic leukemia, where we found both k and lambda pr...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90162-7
更新日期:1987-01-01 00:00:00
abstract::We retrospectively assessed morphologic and cytogenetic responses to 5-azacytidine and decitabine in a cohort of 42 adult therapy-related myelodysplastic syndromes (tMDS) patients treated at Memorial Sloan-Kettering Cancer Center and in 2 industry-sponsored decitabine trials (D0007 and DACO-020). The overall response ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2012.04.025
更新日期:2012-09-01 00:00:00
abstract::Normal human monocytes express Fas and are susceptible to Fas ligand (FasL)-induced apoptosis. Because the myeloid leukemia cell lines HL-60 and THP-1 can be differentiated into functional monocytes and macrophages, we studied their expression of Fas and Fas ligand (FasL) to determine whether there were differentiatio...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(99)00101-0
更新日期:1999-10-01 00:00:00
abstract::We have utilized the MTT assay to measure the metabolic activity of cells from the bone marrow of 55 patients with acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS) and non-clonal disease. Doubling dilutions of cells were exposed to MTT for 3-4 h. The mean optical density of the formazan produced by each c...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00163-8
更新日期:1996-05-01 00:00:00
abstract::Hyperdiploid and non-hyperdiploid multiple myeloma represents distinct biological entities characterized by different patterns of genetic changes. We sought to determine whether ploidy category (non-hyperdiploid versus hyperdiploid) remains stable over time from diagnosis to progression. Of the 43 patients studied (39...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.leukres.2005.07.004
更新日期:2006-03-01 00:00:00