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Efficacy of hypomethylating agents in therapy-related myelodysplastic syndromes.

Abstract：

:We retrospectively assessed morphologic and cytogenetic responses to 5-azacytidine and decitabine in a cohort of 42 adult therapy-related myelodysplastic syndromes (tMDS) patients treated at Memorial Sloan-Kettering Cancer Center and in 2 industry-sponsored decitabine trials (D0007 and DACO-020). The overall response rate (complete remission+marrow CR+hematologic improvement) was 38%, including 6 patients with complete remission (14%), 6 with marrow CR with or without hematologic improvement (14%), and 4 with hematologic improvement alone (10%). We conclude that DNA methyltransferase inhibitors showed activity in tMDS that is roughly comparable to that seen in de novo MDS.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Klimek VM,Dolezal EK,Tees MT,Devlin SM,Stein K,Romero A,Nimer SD

doi

10.1016/j.leukres.2012.04.025

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

1093-7

issue

9

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(12)00200-7

journal_volume

36

pub_type

杂志文章

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