Abstract：
:Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Matsui J,Kiyokawa N,Takenouchi H,Taguchi T,Suzuki K,Shiozawa Y,Saito M,Tang WR,Katagiri YU,Okita H,Fujimoto Jdoi
10.1016/j.leukres.2004.11.015keywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
573-81issue
5eissn
0145-2126issn
1873-5835pii
S0145-2126(04)00395-9journal_volume
29pub_type
杂志文章abstract：:We retrospectively evaluated the prognostic significance of polypharmacy and inappropriate medication use among 150 patients >60 years of age receiving induction chemotherapy for acute myelogenous leukemia (AML). After adjustment for age and comorbidity, increased number of medications at diagnosis (≥ 4 versus ≤ 1) wa...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2014.06.018
更新日期：2014-10-01 00:00:00
abstract：:This study determined IgV(H) gene usage in 228 chronic lymphocytic leukaemia patients to investigate associations between gene usage and other biological or clinical characteristics. V(H)3-48 [N=8] and V(H)3-53 [N=4] gene rearrangements showed biased lambda light chain restriction and were predominantly found in femal...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.03.028
更新日期：2007-02-01 00:00:00
abstract：:Proto-oncogene transcriptional activation was analyzed in a group of MCF 247 MuLv-induced T-cell lymphomas to identify transformation-specific gene activations and determine whether the proviral insertion near a myc gene could promote a peculiar mechanism of transformation through a differential proto-oncogene express...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(90)90007-v
更新日期：1990-01-01 00:00:00
abstract：:The acid phosphatase (AP), beta-glucuronidase (BG), and alpha-naphthyl-acetate esterase (ANAE) distribution and the morphology of stage 0 B-CLL lymphocytes were studied. The results were compared with the same hydrolase equipment and morphology of normal B-cell populations showing the B-CLL-like phenotype, and thus re...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90074-9
更新日期：1987-01-01 00:00:00
abstract：:Based on Bcl-X(L) overexpression studies we identified type I and type II follicular lymphoma cell lines in response to TRAIL. We demonstrate here that either amount of caspase-8 activation or Bid cleavage could not define the dependence on mitochondria. Furthermore, an inhibitor of NF-kappaB, PDTC, enabled TRAIL to a...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2008.09.025
更新日期：2009-06-01 00:00:00
abstract：:Clofarabine (CLO), a purine nucleoside analog with promising efficacy in acute myeloid leukemia (AML), inhibits the ribonucleotidereductase, p53R2. We have shown that p53R2 mRNA is up-regulated by decitabine (DEC), another drug with promising activity in AML. We developed a pharmacodynamic model to characterize the in...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.07.015
更新日期：2012-11-01 00:00:00
abstract：:We performed a comprehensive cost calculation identifying the main cost drivers of treatment of chronic lymphocytic leukaemia in daily practice. In our observational study 160 patient charts were reviewed repeatedly to assess the treatment strategies from diagnosis till the study end. Ninety-seven patients (61%) recei...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2013.10.029
更新日期：2014-01-01 00:00:00
abstract：:We describe changes in antigen expression on HL60 cells with differentiation into granulocytes induced by all-trans retinoic acid (ATRA) or dimethylsulphoxide (DMSO), into monocytes by alpha1,25-dihydroxyvitamin D3 (D3), or into macrophages by 12-O-tetradecanoyl phorbol-13-acetate (TPA). Undifferentiated cells express...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(98)00041-1
更新日期：1998-06-01 00:00:00
abstract：:Human lymphocyte antigen-G (HLA-G) is an immunosuppressive molecule that induces functional silencing of immune component cells and can be responsible for immunosuppression in patients with multiple myeloma (MM). Immune dysfunction is an important feature of MM and leads to infections as well as may promote disease pr...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.02.015
更新日期：2012-07-01 00:00:00
abstract：:Over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), playing a role in leukemogenesis while decreased expression of PU.1 induces AML in mice model. Therefore, we speculated that there is an inverse relationship between these two factors. To clarify this, we measured the expression level of Fl...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.07.015
更新日期：2006-06-01 00:00:00
abstract：:Imatinib is a tyrosine kinase inhibitor and is now used regularly in chronic myeloid leukaemia therapy in chronic phase with great success. This drug due its very nature of action is suspected to be teratogenic hence the patients are counseled not to get pregnant while on this drug. However in world literature few nor...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2008.03.007
更新日期：2008-10-01 00:00:00
abstract：:The Philadelphia (Ph1) chromosome is a specific structural abnormality in which the abl oncogene is activated due to the formation of the novel chimeric gene, bcr/abl. To investigate the clinicopathological role of bcr/abl in Ph1-positive chronic myelogenous leukaemia (CML), we studied the clonal origin of haematopoie...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(92)90139-x
更新日期：1992-01-01 00:00:00
abstract：:The ability of A-MuLV to transform bone marrow cells on in vitro culture in agarose is enhanced by inclusion of conditioned media during infection and culture. The conditioned medium of a non-virus producing A-MuLV transformed fibroblast cell line was synergistic with medium from Whitlock-Witte long-term bone marrow c...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90469-a
更新日期：1991-01-01 00:00:00
abstract：:Leukemic blasts of two patients with acute leukemia exhibited similar characteristics. They were heterogeneous in size with a diameter of 14-30 microns in smears and unclassifiable by morphological, cytochemical, immunophenotypic and ultrastructural examinations. Cytogenetic examinations of both revealed a near-tetrap...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(94)90087-6
更新日期：1994-07-01 00:00:00
abstract：:Using a short term liquid system we have shown that blood from some patients with primary myelofibrosis (PMF) and chronic granulocytic leukaemia (CGL) in megakaryoblastic transformation (CGL-Mk) gives rise to large numbers of progenitor cells committed to the megakaryocyte (Mk) lineage. As assessed by indirect immunof...
journal_title：Leukemia research
pub_type： 历史文章,杂志文章
doi：10.1016/0145-2126(85)90108-0
更新日期：1985-01-01 00:00:00
abstract：:Aneuploidy is a very common prognostic factor in multiple myeloma (MM). Nonhyperdiploidy including near-tetraploidy (NT) is a poor prognostic indicator, compared to hyperdiploidy in multiple myeloma (MM). NT results from endoduplication of hypodiploidy. We report of a 55-year-old female patient diagnosed with advanced...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2010.01.013
更新日期：2010-07-01 00:00:00
abstract：:Mantle cell lymphoma (MCL) is a distinct type of B cell malignancy and accounts for approximately 5-10% of non-Hodgkin's lymphomas (NHL). The characteristic cytogenetic aberration in MCL is the translocation (11;14)(q13;q32) present in virtually all cases. This rearrangement at the BCL1 locus at 11q13 dysregulates the...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(02)00026-7
更新日期：2002-09-01 00:00:00
abstract：:Pyothorax-associated lymphoma (PAL) is a representative form of diffuse large B-cell lymphoma associated with chronic inflammation, in which the Epstein-Barr virus (EBV) genome is consistently detectable in the lymphoma cells of all PAL cases. Cell lines and animal models would be useful for understanding better this ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2013.07.033
更新日期：2013-11-01 00:00:00
abstract：:Two white European males are reported with adult T-cell leukemia (ATL), a disease first described in Japan, but recently also in the U.K. and U.S.A. Both patients presented with lymphadenopathy, but without a mediastinal mass. In addition, one patient had skin infiltrates and the other had hepatosplenomegaly. Morpholo...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(83)90055-3
更新日期：1983-01-01 00:00:00
abstract：:It has been suggested that imatinib mesylate (IM) influences osteogenesis and bone turnover in treated patients. Here we show that the inhibitory effect of IM on cell multiplication is associated with an increased proportion of spliced osteocalcin (OCNs) in leukemia (HL-60) and osteosarcoma cells (MG-63, U-2 OS), desp...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2007.07.020
更新日期：2008-03-01 00:00:00
abstract：:To determine the clinical significance of the T helper 1(Th1)/T helper 2 (Th2) ratio in multiple myeloma, the intracellular IFN-gamma and IL-4 were analyzed by flow cytometry in 56 patients with multiple myeloma. The mean Th1/Th2 ratio of cases in the initial diagnosis phase and the refractory phase were higher than t...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2004.06.003
更新日期：2005-02-01 00:00:00
abstract：:We describe the properties of three monoclonal antibodies (McAbs) (21H73, 37G7 and 49C12) against K562 cell surface antigens correlated with differentiation induced by 12-O-tetradecanoyl phorbol-13-acetate (TPA). Each of the McAbs immunoprecipitated K562 cell surface antigen with molecular weight (MW) of approximately...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90121-9
更新日期：1991-01-01 00:00:00
abstract：:Peripheral neuropathy (PN), with neuropathic pain as main symptom, represents the dose-limiting toxicity of the proteasome inhibitor bortezomib. Aim of this study was to compare the incidence, risk factors, severity and outcome of PN and neuropathic pain in patient treated with bortezomib up-front or at relapse. We st...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.07.022
更新日期：2010-04-01 00:00:00
abstract：:This study aimed at optimizing the conditions for flow cytometric detection of myeloperoxidase (MPO), cytoplasmic CD3 (cCD3), and cytoplasmic CD22 (cCD22), which seem to be more reliable lineage-associated markers in acute leukemia than surface antigens. Fixation methods employing saponin as detergent resulted in accu...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(93)90102-q
更新日期：1993-05-01 00:00:00
abstract：:We describe a 79-year-old man who had massive pleural effusion and a proliferation of prolymphocytic leukemia cells in the peripheral blood, bone marrow, and pleural effusion fluid. Immunophenotyping of leukemia cells revealed either CD3+CD4+CD8-CD25+ or CD3+CD4+CD8+CD25+. The antibody against human T-cell lymphotropi...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.02.029
更新日期：2007-03-01 00:00:00
abstract：:The involvement of histone lysine methyltransferases (HMT) in carcinogenesis is not well understood. Here, we describe a dose-dependent growth and survival inhibitory effects of BIX-01294, a specific inhibitor of euchromatic HMT2, in promyelocytic leukemia HL-60 and NB4 cells. BIX-01294 combined with all-trans retinoi...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2014.04.003
更新日期：2014-07-01 00:00:00
abstract：:We evaluated the cytotoxicity of dimethylsphingosine (DMS) against four human leukemia cell lines: two acute (HL60 and a multi-drug resistance MDR-positive derivative HL60-dox) and two blast crisis chronic myelogenous leukemias (JFP1, from a treatment refractory patient and K562), and against blasts isolated from 11 l...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(01)00129-1
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:Acute myeloid leukemia (AML) represents a heterogeneous disorder with recurrent chromosomal alterations and molecular abnormalities. Among AML with normal karyotype (NK-AML) FLT3 activating mutation, internal tandem duplication (FLT3-ITD), is present in about 30% of patients, conferring unfavorable outcome. ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2015.04.017
更新日期：2015-08-01 00:00:00
abstract：:A combination of monosomy 7 and translocation t(9;22) (q34;q11), rarely observed in acute lymphoblastic leukaemia (ALL), is here reported: a peculiarity of this case was that the "breakpoint cluster region" on chromosome 22 was not rearranged, as demonstrated by molecular analysis, and a new c-abl protein (p190) was f...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90114-7
更新日期：1987-01-01 00:00:00
abstract：:While critical steps in the regulation of leukemia cell development have been intensively studied in recent years, less is known about the interactions of leukemic cells with their stroma. Previously, we have shown that human acute myeloid leukemia (AML) cells differentiate upon injection into murine blastocysts. We h...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2007.09.014
更新日期：2008-05-01 00:00:00
