Abstract：
:Using a short term liquid system we have shown that blood from some patients with primary myelofibrosis (PMF) and chronic granulocytic leukaemia (CGL) in megakaryoblastic transformation (CGL-Mk) gives rise to large numbers of progenitor cells committed to the megakaryocyte (Mk) lineage. As assessed by indirect immunofluorescence the number of cells reacting with three antiplatelet monoclonal antibodies, C17, J15 and AN51, increases during the culture period. There is no equivalent increase in cultures from the blood of normal individuals or patients with essential thrombocythaemia (ET). Furthermore plasma-free supernatants from cultures of the cells from patients with PMF and CGL-Mk stimulate the rate of proliferation of fibroblasts from normal bone marrow. These data provide further evidence for the involvement of the Mk lineage in PMF and CGL and suggest that the excess fibrosis seen in these conditions may be caused by a factor emanating from Mks.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Hibbin JA,Matutes E,Goldman JMdoi
10.1016/0145-2126(85)90108-0subject
Has Abstractpub_date
1985-01-01 00:00:00pages
1171-9issue
9eissn
0145-2126issn
1873-5835journal_volume
9pub_type
历史文章,杂志文章abstract：:We retrospectively assessed morphologic and cytogenetic responses to 5-azacytidine and decitabine in a cohort of 42 adult therapy-related myelodysplastic syndromes (tMDS) patients treated at Memorial Sloan-Kettering Cancer Center and in 2 industry-sponsored decitabine trials (D0007 and DACO-020). The overall response ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.04.025
更新日期：2012-09-01 00:00:00
abstract：:This study determined IgV(H) gene usage in 228 chronic lymphocytic leukaemia patients to investigate associations between gene usage and other biological or clinical characteristics. V(H)3-48 [N=8] and V(H)3-53 [N=4] gene rearrangements showed biased lambda light chain restriction and were predominantly found in femal...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.03.028
更新日期：2007-02-01 00:00:00
abstract：:Nitric oxide (NO) has been shown to be cytotoxic for normal and transformed cell lines. One of the intracellular targets for NO action is glutathione (GSH). GSH determinates cellular redox potential and modulates several biological events. During oxidative and nitrosative stress, glutathione system imbalance is associ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.06.021
更新日期：2006-02-01 00:00:00
abstract：:Bone marrow cells from 109 patients (median age 60) with newly diagnosed acute myeloid leukaemia (AML) were prospectively immunophenotyped (IP) and the prognostic value of monoclonal antibody (MAB) reactivities was analysed to detect differences in complete remission rates and survival, not only between groups of MAB ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90071-z
更新日期：1991-01-01 00:00:00
abstract：:Effects of the HDAC inhibitor LBH-589 (panobinostat) on fludarabine lethality toward acute myeloid leukemia (AML) cells were examined in vitro and in vivo. LBH-589 pretreatment sensitized U937, HL-60, and primary leukemia cells to fludarabine while blocking NF-κB activation accompanied by XIAP down-regulation and JNK ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2011.10.020
更新日期：2012-04-01 00:00:00
abstract：:Radiotherapy (RT)is considered the treatment of choice in patients with Extra-nodal marginal zone lymphoma (EMZL) at early stage, but the presence of late toxicities has been limited the acceptance. Recently, low doses of RT LDR) (2 x 2 Gy) and the use of limited fields has been observed that retain the efficacy but e...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.leukres.2020.106443
更新日期：2020-11-01 00:00:00
abstract：:Despite the evolution of effective frontline treatment strategies, many patients with myeloma inevitably relapse. Treatment can be complicated by the interplay of disease-, treatment-, and patient-related factors. Unfortunately, many patients eventually develop disease that is refractory to lenalidomide and bortezomib...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2014.02.008
更新日期：2014-05-01 00:00:00
abstract：:The present study explored the effects of Forkhead box Q1 (FOXQ1) on cell proliferation, cell cycle and apoptosis via the Sonic hedgehog (Shh) pathway in Natural killer/T-cell lymphoma (NKTCL). Quantitative real time-polymerase chain reaction (qRT-PCR) was performed to detect FOXQ1 expression in 117 NKTCL patients and...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2017.11.001
更新日期：2018-01-01 00:00:00
abstract：:The aim of this study is to detect the biologic and/or prognostic significance of survivin (S) and effector protease receptor 1: EPR-1 (E) expression in acute leukemias (34 ALL and 40 AML) by using RT-PCR. S and E expressions were found in 83.8 and 20.3% of the cases, respectively. S was detected in 90%, 76.5% and E w...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2007.01.005
更新日期：2007-11-01 00:00:00
abstract：:The aim of this study was to elucidate the pathologic sequence changes and associated clinical phenotypes in 9 new patients showing homozygosity for perforin gene among a total of 37 (24%) Turkish FHL families studied by linkage analysis. These 9 unrelated patients (5M/4F) were coming from consanguineous families and ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2007.11.033
更新日期：2008-06-01 00:00:00
abstract：:When spleen cells of mice grafted with STIL-3 C5 cells, a leukemic T-cell line producing IL-3, are cultured in vitro, a high IL-3 activity is detectable in the culture supernatant. However, when bone marrow cells of the same grafted mice are cultured under similar conditions, hardly any IL-3 activity is detectable. To...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(92)90035-6
更新日期：1992-09-01 00:00:00
abstract：:Increasing evidence suggest that epigenetic mechanisms (e.g. histone modification by histone deacetylases) play a major role in the pathogenesis of Hodgkin's lymphoma (HL). We treated HL cell lines with the histone deacetylase inhibitor vorinostat and investigated the gene expression profile of these cells by using DN...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.02.021
更新日期：2012-06-01 00:00:00
abstract：:Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Although several clinical characteristics can be associated with worse prognosis, more robust biological markers still remains uncovered. SMYD2, a member of SMYD protein family, regulates the activity of several proteins through methylation. I...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2014.01.013
更新日期：2014-04-01 00:00:00
abstract：:We investigated Syk as a potential marker of CML progression. We observed a significant over-expression of Syk mRNA and constitutive phosphorylation of Syk Y348 in blast cells from six AP or BP-CML, but not in 15 CML in chronic phase. We could follow in vivo the recurrence of pSyk(348) throughout blast cell escape, de...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2014.11.014
更新日期：2015-03-01 00:00:00
abstract：:The studies aimed at identifying a prognostic significance of angiogenesis-related factors: CD105 and placental growth factor (PlGF) in a course of acute lymphoblastic leukaemia (ALL). Research protocol was based on detection of RNA and protein expressions in bone marrow blasts using quantitative PCR and immunocytoche...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.03.017
更新日期：2012-07-01 00:00:00
abstract：:Several genetic polymorphisms in the genes coding folate-metabolizing enzymes have been associated with susceptibility to hematology malignancies. We conducted a Korean population-based case-control study to examine the relationship between the polymorphisms of folate-metabolizing enzymes and the risk of AML (acute my...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2008.07.026
更新日期：2009-01-01 00:00:00
abstract：:A novel Philadelphia (Ph1) chromosome positive cell line, designated KYO-1, was established from the peripheral blood of a patient with chronic myelogenous leukemia (CML) in blastic crisis. Although this line had a unique capacity to differentiate spontaneously along the erythroid and monocytoid lineages as evidenced ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(85)90314-5
更新日期：1985-01-01 00:00:00
abstract：:Telomere dysfunction might generate genomic instability leading to the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). We investigated telomere length (TL), telomerase activity (TA) and hTERT, c-myc, mad1, and p53 expression in the bone marrow of patients with MDS (n=109), AML (n=47) ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2013.07.022
更新日期：2013-11-01 00:00:00
abstract：:We retrospectively evaluated the prognostic significance of polypharmacy and inappropriate medication use among 150 patients >60 years of age receiving induction chemotherapy for acute myelogenous leukemia (AML). After adjustment for age and comorbidity, increased number of medications at diagnosis (≥ 4 versus ≤ 1) wa...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2014.06.018
更新日期：2014-10-01 00:00:00
abstract：:HSP90 is a multi-client chaperone involved in regulating a large array of cellular processes and is commonly overexpressed in many different cancer types including hematological malignancies. Inhibition of HSP90 holds promise for targeting multiple molecular abnormalities and is therefore an attractive target for hete...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2015.03.016
更新日期：2015-06-01 00:00:00
abstract：:A new cell line, designated MO1043, was established from the peripheral blood (PB) of a patient with B-cell chronic lymphocytic leukemia (CLL). Both the PB leukemia cells and MO1043 were found to have an abnormal cytogenetic marker of trisomy 12, the most common cytogenetic abnormality in CLL. In addition, both the PB...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(93)90154-d
更新日期：1993-10-01 00:00:00
abstract：:Discovering genetic predictors of childhood acute lymphoblastic leukemia (ALL) necessitates the evaluation of novel factors including maternal genetic effects, which are a proxy for the intrauterine environment, and robust epidemiologic study designs. Therefore, we evaluated five maternal and offspring xenobiotic meta...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.leukres.2013.01.020
更新日期：2013-05-01 00:00:00
abstract：:A case of acute monocytic leukemia (AMoL) with t(5;11)(q31;q23) and a case of acute myelomonocytic leukemia (AMMoL) with t(5;11)(q35;q13.1) are reported. The translocation between the long arm of chromosome 11q and that of chromosome 5q with leukemia have been rarely reported. Though breakpoint of both cases were subt...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(99)00033-8
更新日期：1999-07-01 00:00:00
abstract：:Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B (NF-kappaB), which is a target molecule of these kin...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.01.008
更新日期：2005-08-01 00:00:00
abstract：:The effects of two recombinant human CSFs (G-CSF and GM-CSF) on the growth of blast progenitors from 36 acute myeloblastic leukemia patients were studied in methylcellulose and suspension cultures. Blast colony formation in methylcellulose and the growth of blast progenitors in suspension were stimulated by G-CSF or G...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(88)90063-x
更新日期：1988-01-01 00:00:00
abstract：:The prognostic impact of combined NPM1+/FLT3- genotype is not well defined in elderly patients with acute myeloid leukemia (AML), and in the setting of different treatments, such as cytotoxic chemotherapy (Chemo), hematopoietic cell transplantation (HCT), or hypomethylating agents (HMA). Eighty-two elderly (age >60 ye...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2015.09.001
更新日期：2015-09-03 00:00:00
abstract：:Aggressive chemotherapy of myelodysplastic syndromes is rarely feasible because these disorders predominantly occur in elderly patients who often have concurrent illnesses. Alternative treatment modalities must therefore be evaluated. This review summarizes the results that have been obtained with low-dose chemotherap...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/0145-2126(92)90058-f
更新日期：1992-01-01 00:00:00
abstract：:Bcr-Abl tyrosine kinase inhibitor induces apoptosis and erythroid differentiation of K562 cells. During this erythroid differentiation, c-Myc and cyclin D1 transcripts are transiently downregulated. Accordingly, we studied the effect of cyclin D1 overexpression on erythroid differentiation. After treatment with 250 nM...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2003.10.022
更新日期：2004-06-01 00:00:00
abstract：:We have demonstrated that constitutive signal transducer and activator of transcription (STAT) 3 activity, observed in approximately 50% of acute myeloid leukemia (AML) cases, is associated with adverse treatment outcome. Constitutive STAT3 activation may result from the expression of oncogenic protein tyrosine kinase...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2007.11.035
更新日期：2008-07-01 00:00:00
abstract：:Leukemic blasts of two patients with acute leukemia exhibited similar characteristics. They were heterogeneous in size with a diameter of 14-30 microns in smears and unclassifiable by morphological, cytochemical, immunophenotypic and ultrastructural examinations. Cytogenetic examinations of both revealed a near-tetrap...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(94)90087-6
更新日期：1994-07-01 00:00:00
