Abstract:
:We investigated Syk as a potential marker of CML progression. We observed a significant over-expression of Syk mRNA and constitutive phosphorylation of Syk Y348 in blast cells from six AP or BP-CML, but not in 15 CML in chronic phase. We could follow in vivo the recurrence of pSyk(348) throughout blast cell escape, despite observing storage of dasatinib in blast cells. A combination of dasatinib and R406 did not improve therapeutic efficacy in vitro. Our results strongly suggest that Syk activation could be a relevant biomarker of disease progression and dasatinib resistance but is probably not a molecular target.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Bourgne C,Janel A,Berger J,Rapatel C,Tournilhac O,Hermet E,Guerci A,Lioret F,Briançon A,Bamdad M,Boiret-Dupré N,Berger MGdoi
10.1016/j.leukres.2014.11.014subject
Has Abstractpub_date
2015-03-01 00:00:00pages
329-34issue
3eissn
0145-2126issn
1873-5835pii
S0145-2126(14)00366-Xjournal_volume
39pub_type
杂志文章abstract::T-cell leukemias were induced in adult BDF1 mice by a single i.v. injection of methylnitrosourea (MNU). Leukemogenesis was delayed by a single or repeated injections of hydrocortisone (HC) after MNU and also when HC was given one day before MNU. Enhancement of leukemogenesis was seen in experiments with 10 and 14 days...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(85)90143-2
更新日期:1985-01-01 00:00:00
abstract::This prospective phase II clinical trial evaluated the effects of single-dose mitoxantrone (36 mg/m2 on day 1) in combination with continuous infusion intermediate-dose cytarabine plus etoposide in 25 patients with refractory or early relapsed acute myeloid leukemia (AML). We compared the results of our current study ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2008.08.009
更新日期:2009-04-01 00:00:00
abstract::A national cooperative group trial was conducted in 153 patients with chronic myelogenous leukemia (CML) in chronic phase treated with oral pulse busulfan to determine if oral vitamin A can increase the time to blast crisis and enhance survival of patients. Patients diagnosed within 1 year and in the chronic phase of ...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/0145-2126(95)00032-j
更新日期:1995-09-01 00:00:00
abstract::Many evidences have shown that dietary intake of cruciferous vegetables could protect against the risk of various types of malignancies. Benzyl isothiocyanate (BITC), one of the compounds from cruciferous vegetables, had shown induced cell cycle arrest and apoptosis in cancer cells. However, there is no available info...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.01.030
更新日期:2009-11-01 00:00:00
abstract::Human peripheral blood monocytes were found to be capable of phagocytizing human B-non Hodgkin's lymphoma (NHL) cells coated with mouse monoclonal antibodies (MoAbs). The MoAbs used recognized idiotypic determinants on the surface immunoglobulin (Ig) of the tumor cells. MoAbs of IgG1 and IgG2a subclass were equally ef...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(86)90344-9
更新日期:1986-01-01 00:00:00
abstract::We investigated the effects of two sex steroids (17beta estradiol and testosterone) on five human leukemia cell lines. We observed a statistically significant inhibition of proliferation, dose and time dependent, of the human monoblastic leukemia cell line U937. This inhibition was associated with a dose dependent dec...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(98)00101-5
更新日期:1998-11-01 00:00:00
abstract::We have utilized the MTT assay to measure the metabolic activity of cells from the bone marrow of 55 patients with acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS) and non-clonal disease. Doubling dilutions of cells were exposed to MTT for 3-4 h. The mean optical density of the formazan produced by each c...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00163-8
更新日期:1996-05-01 00:00:00
abstract::Proto-oncogene transcriptional activation was analyzed in a group of MCF 247 MuLv-induced T-cell lymphomas to identify transformation-specific gene activations and determine whether the proviral insertion near a myc gene could promote a peculiar mechanism of transformation through a differential proto-oncogene express...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(90)90007-v
更新日期:1990-01-01 00:00:00
abstract::Clofarabine (CLO), a purine nucleoside analog with promising efficacy in acute myeloid leukemia (AML), inhibits the ribonucleotidereductase, p53R2. We have shown that p53R2 mRNA is up-regulated by decitabine (DEC), another drug with promising activity in AML. We developed a pharmacodynamic model to characterize the in...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2012.07.015
更新日期:2012-11-01 00:00:00
abstract::The present study explored the effects of Forkhead box Q1 (FOXQ1) on cell proliferation, cell cycle and apoptosis via the Sonic hedgehog (Shh) pathway in Natural killer/T-cell lymphoma (NKTCL). Quantitative real time-polymerase chain reaction (qRT-PCR) was performed to detect FOXQ1 expression in 117 NKTCL patients and...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.11.001
更新日期:2018-01-01 00:00:00
abstract::AG-013736 is an oral anti-angiogenesis agent with activity against a variety of receptor tyrosine kinases, including VEGFR-1, VEGFR-2, VEGFR-3, c-kit, and PDGFR-beta. A phase 2 study was conducted in patients with poor prognosis AML or MDS. Twelve patients (six AML; six MDS) were treated with AG-013736 at a dose of 10...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2005.10.024
更新日期:2006-07-01 00:00:00
abstract::Pyothorax-associated lymphoma (PAL) is a representative form of diffuse large B-cell lymphoma associated with chronic inflammation, in which the Epstein-Barr virus (EBV) genome is consistently detectable in the lymphoma cells of all PAL cases. Cell lines and animal models would be useful for understanding better this ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.07.033
更新日期:2013-11-01 00:00:00
abstract::The MTT cell viability assay is widely used in determining drug sensitivity profiles for patients with hematological malignancies and in primary screening of potential chemotherapeutic drugs. Because the multidrug resistance (MDR) phenotype is associated with these malignancies, and since many vital dyes are effluxed ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(92)90114-m
更新日期:1992-12-01 00:00:00
abstract::We have demonstrated that constitutive signal transducer and activator of transcription (STAT) 3 activity, observed in approximately 50% of acute myeloid leukemia (AML) cases, is associated with adverse treatment outcome. Constitutive STAT3 activation may result from the expression of oncogenic protein tyrosine kinase...
journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/j.leukres.2007.11.035
更新日期:2008-07-01 00:00:00
abstract::We analysed the optimal conditions for autologous bone marrow purging using complement binding monoclonal antibodies (mAbs). Twelve mAbs belonging to four clusters (CD9, CD10, CD19, CD24), alone or combined were evaluated by using direct cytotoxicity and clonogenic assays. We observed the following data: (1) optimal c...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90117-2
更新日期:1987-01-01 00:00:00
abstract::A patient with myelodysplastic syndromes (MDS) developed eosinophilia during treatment with recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF). To study the mechanism of this eosinophilia, we investigated the proliferation of eosinophil colony-forming units (CFU-Eo) in nine patients and four...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00083-6
更新日期:1995-12-01 00:00:00
abstract::The usefulness of a new method to detect B-cell monoclonality named VR, which is a combination of the digestion with restriction enzymes and vectorette PCR, in aspiration biopsy-nucleic acid diagnosis (ABND) of thyroid malignant lymphoma was investigated. ABND was performed in 12 patients in whom malignant lymphoma wa...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.03.019
更新日期:2008-01-01 00:00:00
abstract::The effects of prostaglandin (PG)E1, PGD2 and 9-deoxy-delta 9-PGD2 (PGJ2) on the clonogenic growth of six kinds of human leukemic cell lines (K562, KG1, HL60, U937, THP1 and Molt4) and normal human myeloid progenitor cells (CFU-GM) were studied using semisolid agar cultures. While the degree of suppression of leukemic...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(86)90087-1
更新日期:1986-01-01 00:00:00
abstract::To examine the possibility that ETS family transcription factors, PU.1, SPI-B, ELF-1, ERG-3, ETS-1 and TEL, and homeodomain proteins, HOXA10, HOXC13, MEIS1 and PBX1B, function cooperatively, we investigated their interactions. In luciferase assays, HOXA10 and HOXC13 augmented the activity of PU.1 and SPI-B while dimin...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2008.07.002
更新日期:2009-03-01 00:00:00
abstract::A 53-year-old male patient was admitted to our hospital with painful splenomegaly. He was diagnosed as having chronic myelomonocytic leukemia (CMML) with leukocytosis, monocytosis, increased lysozyme concentrations in serum und urine, and lack of the Philadelphia chromosome. The clinical course of the disease was char...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(96)00117-8
更新日期:1997-03-01 00:00:00
abstract::Mantle cell lymphoma (MCL) an incurable B-cell, non-Hodgkin lymphoma (NHL) urgently requires new treatments. We assessed reovirus mediated oncolysis in a panel of human MCL cell lines. In vitro, we found the cytopathic effect of reovirus infection ranged from high to very limited and correlated with levels of Ras acti...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.05.020
更新日期:2010-01-01 00:00:00
abstract::IL-3 stimulated the production of IL-6 from a bone marrow-adherent cell population, macrophages and from hemopoietic supportive stromal cell lines. It also induced IL-6 production from a stem cell-enriched population of bone marrow cells which did not produce IL-6 without stimulation. In contrast, stimulation with IL-...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(91)90180-2
更新日期:1991-01-01 00:00:00
abstract::Increased DNA damage and alteration of the DNA damage response (DDR) are critical features of genetic instability presumably implicated in pathogenesis of myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML). We used immunofluorescence staining of γH2AX and 53BP1 for analyzing DNA double-strand breaks (DS...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.03.011
更新日期:2017-06-01 00:00:00
abstract::Osteopontin (OPN) is a cytokine that contributes substantially to the growth and metastasis in a wide spectrum of malignancies. We report here that OPN gene is transactivated by Tax protein of human T-cell leukemia virus type 1 (HTLV-1). Northern blot showed enhanced OPN gene expression in cells stably expressing Tax....
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.08.028
更新日期:2010-06-01 00:00:00
abstract::The ability of pH-sensitive liposomes and immunoliposomes to deliver synthetic antisense oligonucleotides (oligos) into human myeloid and lymphoid leukaemia cells was examined. The cellular uptake of an 18mer anti-myb oligonucleotide encapsulated in liposomes was from three- to five-fold higher than that of 32P-oligos...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(96)00062-8
更新日期:1996-11-01 00:00:00
abstract::An acute promyelocytic leukemia in the rat (BNML) has been used in model studies on pathogenesis and therapy of human acute myeloid leukemia. The blood supply to bone marrow during BNML development has hitherto not been examined, even though in general, blood flow to hematopoietic tissues might affect drug treatment a...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(93)90071-r
更新日期:1993-08-01 00:00:00
abstract::The concurrent development of chronic myeloid (CML) or myelomonocytic (CMML) leukemia in patients with systemic mastocytosis (SM) is a well recognized phenomenon. Although the leukemia often resembles CML in morphological and in clinical terms, a Ph-Chromosome-positive variant has not been reported in SM so far. We he...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2005.04.004
更新日期:2005-10-01 00:00:00
abstract::An insertion (10;11)(p11;q23q24) was found in bone marrow metaphase cells from two children with acute monocytic leukemia (AMoL-M5b). This rearrangement involves a small chromosomal segment of 11q and may be misinterpreted as a deletion of 11q. Insertion (10;11) may represent a new recurring abnormality involving 11q ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(85)90140-7
更新日期:1985-01-01 00:00:00
abstract::Bone marrow cells from 9 patients with acute myeloid leukemia and 1 patient with a blast crisis of chronic myeloid leukemia were cultured to determine their ability to be induced to differentiate by different chemotherapeutic compounds. Five of these 10 patients showed differentiation to granulocytic and/or monocytic ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(85)90087-6
更新日期:1985-01-01 00:00:00
abstract::Screening for loss of heterozygosity (LOH) of the panel of 18 highly polymorphic microsatellite markers, especially from the region 11p15, was carried out on 154 samples from 26 patients with acute myeloid leukemia and eight with myelodysplastic syndromes (MDS). LOH was detected at the majority (72%) of the loci teste...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(00)00086-2
更新日期:2001-01-01 00:00:00