Abstract:
:The effects of prostaglandin (PG)E1, PGD2 and 9-deoxy-delta 9-PGD2 (PGJ2) on the clonogenic growth of six kinds of human leukemic cell lines (K562, KG1, HL60, U937, THP1 and Molt4) and normal human myeloid progenitor cells (CFU-GM) were studied using semisolid agar cultures. While the degree of suppression of leukemic growth by PGE1 varied from cell line to cell line, PGD2 and PGJ2 equally suppressed the growth of all leukemic cell lines. The potency of growth inhibition was as follows: PGJ2 greater than PGD2 greater than PGE1. The increase of cellular cAMP level induced by prostaglandin treatment did not parallel their cytotoxic potency. Normal myeloid colony formation was also suppressed by PGE1, PGD2 or PGJ2. In contrast to the preferential inhibition of macrophage colony formation by PGE1, such lineage-selective suppression was not observed for PGD2 or PGJ2. These findings suggest that PGD2 and PGJ2 potently inhibit the leukemic growth by a different mechanism from that of PGE1 and by a cAMP-independent mechanism. These prostaglandins seem to be promising chemotherapeutic agents for acute leukemia.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Tsao CJ,Ozawa K,Hosoi T,Urabe A,Takaku Fdoi
10.1016/0145-2126(86)90087-1subject
Has Abstractpub_date
1986-01-01 00:00:00pages
527-32issue
5eissn
0145-2126issn
1873-5835journal_volume
10pub_type
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
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journal_title:Leukemia research
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doi:10.1016/j.leukres.2008.08.009
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(83)90018-8
更新日期:1983-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.02.028
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(89)90028-3
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2004.07.012
更新日期:2005-03-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(82)90031-5
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pub_type: 信件
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更新日期:2006-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2019.05.004
更新日期:2019-07-01 00:00:00
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doi:10.1016/0145-2126(83)90067-x
更新日期:1983-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(98)00069-1
更新日期:1998-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.03.028
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To analyze the frequency, clinical characteristics, and prognosis of IGH deletion in multiple myeloma (MM). METHODS:A total of 310 consecutive patients with multiple myeloma were analyzed. Among them 251 patients were newly diagnosed and 59 patients were previously treated, fluorescence in situ hybridization...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2015.02.010
更新日期:2015-05-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(88)90034-3
更新日期:1988-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.09.028
更新日期:2010-02-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.11.010
更新日期:2007-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(03)00005-5
更新日期:2003-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(02)00175-3
更新日期:2003-04-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.leukres.2020.106385
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