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Ph-negative acute lymphocytic leukemia occurring after interferon therapy for Ph-positive chronic myelocytic leukemia.

Abstract：

:We report a unique case of chronic myelocytic leukemia (CML) with the Philadelphia (Ph) chromosome. The patient obtained cytogenetic complete remission (CR) after treatment with interferon (IFN). When he transformed to acute lymphocytic leukemia (ALL), cytogenetic analysis showed that the karyotype was normal and fluorescence in situ hybridization (FISH) indicated that blast cells were Ph-negative. Immunophenotyping showed that the cells were CD34-positive and CD38-negative. Blast cells in his final stage were BCR/ABL rearrangement negative by reverse transcription polymerase chain reaction (RT-PCR).

journal_name

Leuk Res

journal_title

Leukemia research

authors

Zhang X,Ji L,Liu S,Wang J

doi

10.1016/s0145-2126(02)00175-3

keywords:

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

367-9

issue

4

eissn

0145-2126

issn

1873-5835

pii

S0145212602001753

journal_volume

27

pub_type

杂志文章

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