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Imatinib mesylate discontinuation in patients with chronic myeloid leukemia who have received front-line imatinib mesylate therapy and achieved complete molecular response.

Abstract：

:The aims were to investigate the feasibility of imatinib mesylate (IM) discontinuation in chronic myeloid leukemia patients who were initially treated with IM and achieved complete molecular response (CMR). Fourteen patients were included. Ten were relapsed within 9.5 months after discontinuation of IM. All 7 patients with high Sokal risk were relapsed. The probability of CMR persistence at 1-year was 28.6%. All relapsed patients were still responsive to IM. A high Sokal risk and delayed acquisition of CMR were associated with relapse. IM discontinuation in patients achieved CMR after treatment with front-line IM might be feasible. Further studies are warranted.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Yhim HY,Lee NR,Song EK,Yim CY,Jeon SY,Shin S,Kim JA,Kim HS,Cho EH,Kwak JY

doi

10.1016/j.leukres.2012.02.011

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

689-93

issue

6

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(12)00071-9

journal_volume

36

pub_type

杂志文章,多中心研究

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