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Establishment of a novel cell line with T-lineage phenotype (HPB-MLp-W) from a non-Hodgkin's lymphoma patient.

Abstract：

:We report the characterization of a novel human T-cell line, HPB-MLp-W, which was established from blastic cells of a lymph node specimen from a patient with non-Hodgkin's lymphoma. They demonstrated the T-cell association antigens, CD2 and CD4, but no CD3, CD8, CD1, CD5, CD7 nor T-cell antigen receptor on their cell surfaces. They were also positive for Ia and Ki-1 antigen, and negative for CD25 (Tac-1). The cell line HPB-MLp-W had the same pattern of antigen expression as the patient's cells. Southern-blot analysis of DNA showed a rearrangement of the T-cell receptor-alpha and beta genes. To our knowledge, this is a novel cell line with unique T-lineage marker, to be established from a case of non-Hodgkin's lymphoma.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Morikawa S,Morikawa K,Hara J,Nagasaki M,Nakano A,Oseko F

doi

10.1016/0145-2126(91)90014-k

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

381-9

issue

5

eissn

0145-2126

issn

1873-5835

journal_volume

15

pub_type

杂志文章

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