Flow cytometric detection of aneuploid CD38(++) plasmacells and CD19(+) B-lymphocytes in bone marrow, peripheral blood and PBSC harvest in multiple myeloma patients.

abstract：:We present our first experiences with determination of minimal residual disease (MRD) based on patient specific Flt3-ITD (internal tandem duplication) mutations. We analysed MRD status of 11 AML patients in a retrospective investigation and its potential impact on the follow up of these patients. In five out of six pa...

journal_title：Leukemia research

authors： Scholl S,Loncarevic IF,Krause C,Kunert C,Clement JH,Höffken K

更新日期：2005-07-01 00:00:00

abstract：:Pyothorax-associated lymphoma (PAL) is a representative form of diffuse large B-cell lymphoma associated with chronic inflammation, in which the Epstein-Barr virus (EBV) genome is consistently detectable in the lymphoma cells of all PAL cases. Cell lines and animal models would be useful for understanding better this ...

journal_title：Leukemia research

authors： Taniguchi A,Hashida Y,Nemoto Y,Taguchi T,Iwahara Y,Daibata M

更新日期：2013-11-01 00:00:00

abstract：:The MYBL2 gene encodes a transcription factor implicated in cell proliferation and maturation whose amplification or overexpression has been associated with different human malignancies, suggesting that it could be implicated in tumorigenesis. We analyzed MYBL2 expression and its prognostic value in 291 patients with ...

journal_title：Leukemia research

authors： Fuster O,Llop M,Dolz S,García P,Such E,Ibáñez M,Luna I,Gómez I,López M,Cervera J,Montesinos P,Moscardó F,Cordón L,Solves P,de Juan I,Palanca S,Bolufer P,Sanz MÁ,Barragán E

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Chromosomal aberrations at the ETV6 gene locus on 12p13.2 are common in bone marrow samples involved by blastic plasmacytoid dendritic cell neoplasm (BPDCN). However, their pathogenic role, incidence in cutaneous BPDCN lesions, and clinical significance have not been assessed systematically. RESULTS:The stu...

journal_title：Leukemia research

authors： Tang Z,Li Y,Wang W,Yin CC,Tang G,Aung PP,Hu S,Lu X,Toruner GA,Medeiros LJ,Khoury JD

更新日期：2018-10-01 00:00:00

abstract：:Resistance to chronic myeloid leukemia (CML) drug STI571 has been associated with point mutations in the kinase domain of BCR-ABL. For example, the mutation T315I (g. 68721C>T) and, to a lesser extent, Y253F (g. 58796A>T) appear in a significant proportion of patients resistant to treatment. Mutations appear intimatel...

journal_title：Leukemia research

authors： Liu WH,Makrigiorgos GM

更新日期：2003-11-01 00:00:00

abstract：:Although verapamil, cyclosporin A. cremophor EL and PSC-833 are active as multidrug resistance modulators, there has been limited study of these compounds as possible chemotherapy enhancing agents against drug-sensitive tumors. We compared these agents as modifiers of VP-16 cytotoxicity in vitro and modifiers of VP-16...

journal_title：Leukemia research

authors： Slater L,Sweet P,Wetzel M,Stupecky M,Osann K

更新日期：1995-08-01 00:00:00

abstract：:Imatinib is a highly effective drug for the treatment of chronic myeloid leukemia (CML) that targets the BCR-ABL kinase. However, a number of patients have CML that is resistant to Imatinib treatment. In this report, we developed AGM130 as a potential therapeutic drug for Imatinib-resistant CML treatment. The AGM130 c...

journal_title：Leukemia research

authors： Kim WS,Lee MJ,Kim DH,Lee JE,Kim JI,Kim YC,Song MR,Park SG

更新日期：2013-04-01 00:00:00

abstract：:Recently, we identified a novel chromosomal rearrangement in Hodgkin lymphoma (HL), t(4;8)(q27;q24), which targets homeobox gene ZHX2 at the recurrent breakpoint 8q24. This aberration deletes the far upstream region of ZHX2 and results in silenced transcription pinpointing loss of activatory elements. Here, we have lo...

journal_title：Leukemia research

authors： Nagel S,Schneider B,Meyer C,Kaufmann M,Drexler HG,Macleod RA

更新日期：2012-05-01 00:00:00

abstract：:This study was aimed to illustrate the significance of minimal residual disease (MRD) assessment on day 22 in childhood acute lymphoblastic leukemia. MRD were measured on day 22, day 36, week 12, month 6 and month 12 by four-color flow cytometry. The 5-year cumulative incidence of relapse was significantly different f...

journal_title：Leukemia research

authors： Xu XJ,Tang YM,Shen HQ,Song H,Yang SL,Shi SW,Xu WQ

更新日期：2012-08-01 00:00:00

abstract：:The prognosis of patients with advanced refractory lymphoma remains poor. We have carried out a Phase II study of continuous high dose intravenous recombinant interleukin 2 alone without LAK cells in this group of patients. Eight patients have so far been treated, 4 with non-Hodgkins lymphoma and 4 with Hodgkins disea...

journal_title：Leukemia research

authors： Lim SH,Worman CP,Callaghan T,Jewell A,Smith MP,Goldstone AH

更新日期：1991-01-01 00:00:00

abstract：:We designed a pharmacokinetic and pharmacodynamic phase I study of sequential topotecan (2.55-6.3mg/m2) by 72h infusion followed by five daily doses of etoposide for patients with refractory acute leukemia based upon synergistic anti-tumor activity of topoisomerase I and II inhibitors in vitro. Eight of the 29 patient...

journal_title：Leukemia research

authors： Cooper BW,Donaher E,Lazarus HM,Green SB,Gosky DM,Rosenthal NS,Berger SJ,Li X,Ingalls ST,Hoppel CL,Gerson SL

更新日期：2003-01-01 00:00:00

abstract：:A permanent lymphoblastoid cell line was established from the peripheral blood of a child with acute lymphoblastic leukemia. The cell line, designated SDK, grows in a stationary suspension culture, forming aggregates, in RPMI medium supplemented with 10% FCS, with a doubling time of 50-60 h. Immunologic markers and cy...

journal_title：Leukemia research

authors： Kottaridis S,Perez S,Kokkinopoulos D,Delinassios JG,Pangalis GA,Cosmidis H,Goula I,Papamichail M

更新日期：1985-01-01 00:00:00

abstract：:Quantitative differences in HLe-1 expression were studied on normal lymphocytes and lymphoblasts of patients with acute lymphoblastic leukemia (ALL). A relationship was found between quantitative antigen expression and therapeutic outcome. Alterations in fluorescence intensity (FI) were demonstrated using quantitative...

journal_title：Leukemia research

authors： Caldwell CW,Patterson WP,Hakami N

更新日期：1987-01-01 00:00:00

abstract：:While MDS was only recently viewed as an orphan disease without any FDA approved therapeutic options, the landscape has changed dramatically with a promise for development of exciting new therapeutics that parallels our growing understanding of the pathobiology of the disease. An array of new agents is entering clinic...

journal_title：Leukemia research

authors： List AF

更新日期：2012-12-01 00:00:00

abstract：:Two white European males are reported with adult T-cell leukemia (ATL), a disease first described in Japan, but recently also in the U.K. and U.S.A. Both patients presented with lymphadenopathy, but without a mediastinal mass. In addition, one patient had skin infiltrates and the other had hepatosplenomegaly. Morpholo...

journal_title：Leukemia research

authors： Tricot GJ,Broeckaert-Van Orshoven A,den Ottolander GJ,de Wolf-Peeters C,Meyer CJ,Verwilghen RL,Jansen J

更新日期：1983-01-01 00:00:00

abstract：:Retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (D3) are well known for inducing differentiation in many leukemic cell lines. The nuclear signalling pathways of RA and D3 are mediated through their cognate receptors, the retinoic acid receptor (RAR) and vitamin D3 receptor (VDR), respectively. Retinoid X receptor (RXR...

journal_title：Leukemia research

authors： Nakajima H,Kizaki M,Ueno H,Muto A,Takayama N,Matsushita H,Sonoda A,Ikeda Y

更新日期：1996-08-01 00:00:00

abstract：:To determine the role of cell-mediated immunity (CMI) to cytomegalovirus (CMV) in leukemic children after CMV infection, CMI to CMV antigen was studied using CMV-specific lymphocyte blastogenic responses (LBR) and interferon (IFN) production. Four children, who continuously secreted CMV in urine more than 2 years afte...

journal_title：Leukemia research

authors： Ihara T,Yasuda N,Isaji M,Torigoe S,Ito M,Kamiya H,Sakurai M

更新日期：1994-07-01 00:00:00

abstract：:The aim of this study was to describe the presenting features, the frequency and outcome of myeloid sarcoma (MS) diagnosed in our Institution from January 1995 to December 2000. Twelve MS were seen and the frequency account for only 2% of all acute myeloid leukemia (AML) patients observed in our department in the same...

journal_title：Leukemia research

authors： Breccia M,Mandelli F,Petti MC,D'Andrea M,Pescarmona E,Pileri SA,Carmosino I,Russo E,De Fabritiis P,Alimena G

更新日期：2004-11-01 00:00:00

abstract：:Introduction of the maturation index (MI) as a measure for the degree of maturation improved the subtyping of acute myeloid leukemia (AML). A comparison is made here between the MI and the results of surface marker analysis with a panel of monoclonal antibodies (McAb) in the immunofluorescence technique. The McAb appl...

journal_title：Leukemia research

authors： van Rhenen DJ,van der Reijden HJ,van't Veer MB,Engelfriet CP,von dem Borne AE,Langenhuijsen MM

更新日期：1983-01-01 00:00:00

abstract：:We have studied the survival of clonogenic neoplastic cells of a murine pre-B-lymphoma (BCl-1) of the spleen in culture. We have found quantitative deficiencies such as reduced surface adherence of stromal cells and impaired CFU-F (colony forming units-fibroblast) and pre-CFU-F colony and layer formation in stromal cu...

journal_title：Leukemia research

authors： Prindull G,Ben-Ishay Z,Bergholz M,Prindull B

更新日期：1993-07-01 00:00:00

abstract：:In order to investigate the clinical significance of IgG subclass levels in adult patients treated for acute lymphocytic (ALL) or myelogenous leukemias (AML), patients were tested before and in regular intervals during and after chemotherapy. Ten patients treated for acute lymphocytic leukemia had normal total IgG and...

journal_title：Leukemia research

authors： Gause A,Schmitz G,von Kalle AK,Lathan B,Diehl V,Pfreundschuh M

更新日期：1992-01-01 00:00:00

abstract：:In a recent phase I study, a combination of gemcitabine at 10 mg/(m(2)min) for 12 h and mitoxantrone 12 mg/m(2) daily for 3 days, achieved a complete remission (CR) in 3 of 12 (25%) patients with refractory leukemia. A pilot assessment of this regimen was conducted to determine its tolerability in patients with refrac...

journal_title：Leukemia research

authors： Apostolidou E,Estey E,Cortes J,Garcia-Manero G,Faderl S,Thomas D,Tsimberidou A,Kantarjian H,Giles FJ

更新日期：2003-04-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a distinct type of B cell malignancy and accounts for approximately 5-10% of non-Hodgkin's lymphomas (NHL). The characteristic cytogenetic aberration in MCL is the translocation (11;14)(q13;q32) present in virtually all cases. This rearrangement at the BCL1 locus at 11q13 dysregulates the...

journal_title：Leukemia research

authors： Drexler HG,MacLeod RA

更新日期：2002-09-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Leukemia research

authors： Zengwang,Zhou HJ,Li A,Zhang JL

更新日期：2009-02-20 00:00:00

abstract：:A synthetic pentadecapeptide preparation, env 406-420, with an amino acid sequence deduced from the envelope glycoprotein gene of human T cell leukemia virus type I (HTLV I), was used as the antigen in an enzyme immunoassay for immunoglobulin G antibodies, exploring its usefulness for seroepidemiological purposes. The...

journal_title：Leukemia research

authors： Blomberg J,Fölsch G,Nilsson I,Fäldt R

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVES:Follicular lymphoma (FL) is generally considered an indolent disorder but a significant subset of patients shows a worse outcome. Aim of this study was to validate the FLIPI score in an independent series of follicular lymphoma patients and to correlate prognostic categories with the period of diagnosis and ...

journal_title：Leukemia research

authors： Arcaini L,Colombo N,Passamonti F,Burcheri S,Orlandi E,Brusamolino E,Della Porta M,Rumi E,Montanari F,Pascutto C,Paulli M,Lazzarino M

更新日期：2006-03-01 00:00:00

abstract：:Telomere dysfunction might generate genomic instability leading to the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). We investigated telomere length (TL), telomerase activity (TA) and hTERT, c-myc, mad1, and p53 expression in the bone marrow of patients with MDS (n=109), AML (n=47) ...

journal_title：Leukemia research

authors： Poloni A,Serrani F,Berardinelli E,Maurizi G,Mariani M,Costantini B,Trappolini S,Mancini S,Olivieri A,Leoni P

更新日期：2013-11-01 00:00:00

abstract：:The MTT cell viability assay is widely used in determining drug sensitivity profiles for patients with hematological malignancies and in primary screening of potential chemotherapeutic drugs. Because the multidrug resistance (MDR) phenotype is associated with these malignancies, and since many vital dyes are effluxed ...

journal_title：Leukemia research

authors： Marks DC,Belov L,Davey MW,Davey RA,Kidman AD

更新日期：1992-12-01 00:00:00

abstract：:Chronic B-lymphocytic leukemia (B-CLL) cells may be regulated by immune functions. In an attempt to analyze such functions, helper factors (IL-1 alpha, IL-1 beta and IL-6), T-cell products (sCD4 and sCD8) and sIL-2R and beta 2-microglobulin were measured in serum of patients at different stages of the disease. Patient...

journal_title：Leukemia research

authors： Aguilar-Santelises M,Loftenius A,Ljungh C,Svenson SB,Andersson B,Mellstedt H,Jondal M

更新日期：1992-06-01 00:00:00

abstract：:The levels of expression of the activation antigen CD98 were studied by mAB CAF7 in 51 newly diagnosed consecutive cases of childhood acute lymphoblastic leukemia aged from 1 to 13 years. The mean follow-up was 8 months. A wide range of CAF7 expression was observed, the highest mean fluorescence intensity exceeding th...

journal_title：Leukemia research

authors： Taskov H,Pashov A,ffmitrova E,Yordanova M,Serbinova M

更新日期：1996-01-01 00:00:00