Abstract:
:Two white European males are reported with adult T-cell leukemia (ATL), a disease first described in Japan, but recently also in the U.K. and U.S.A. Both patients presented with lymphadenopathy, but without a mediastinal mass. In addition, one patient had skin infiltrates and the other had hepatosplenomegaly. Morphologic and ultrastructural examination of the blasts in bone marrow and lymph node biopsy revealed a predominance of polymorphic lymphoid cells with pronounced nuclear irregularities and a semi-mature chromatine pattern. Histopathology of the lymph nodes showed a diffuse infiltration with medium-sized lymphoblasts with irregular nuclei. The blasts in the bone marrow formed E rosettes with sheep erythrocytes, lacked terminal deoxynucleotidyl transferase (Tdt) activity but expressed the Ia-like antigen; although the majority of the cells reacted with a polyclonal anti-T-cell serum, they were negative for OKT3. In one patient a helper/inducer phenotype (OKT4+) was found in the lymphoblasts of bone marrow and lymph node, while in the other only in the lymph node. The difference between bone marrow and lymph node phenotype is discussed. To our knowledge, these are the first two European patients reported with ATL, a disease clearly different from convoluted T-cell acute lymphocytic leukemia.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Tricot GJ,Broeckaert-Van Orshoven A,den Ottolander GJ,de Wolf-Peeters C,Meyer CJ,Verwilghen RL,Jansen Jdoi
10.1016/0145-2126(83)90055-3subject
Has Abstractpub_date
1983-01-01 00:00:00pages
31-42issue
1eissn
0145-2126issn
1873-5835pii
0145-2126(83)90055-3journal_volume
7pub_type
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journal_title:Leukemia research
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journal_title:Leukemia research
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更新日期:2008-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,meta分析,评审
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更新日期:2018-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00187-4
更新日期:2002-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2014.11.025
更新日期:2015-02-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2011.03.017
更新日期:2011-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.03.011
更新日期:2017-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(92)90035-6
更新日期:1992-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.08.006
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0145-2126(02)00032-2
更新日期:2002-12-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(92)90009-v
更新日期:1992-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.02.013
更新日期:2007-02-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,评审
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更新日期:2008-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 总体
doi:10.1016/j.leukres.2008.03.009
更新日期:2008-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(99)00139-3
更新日期:2000-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90162-7
更新日期:1987-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2010.06.012
更新日期:2010-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
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更新日期:2000-07-01 00:00:00
abstract::This study evaluated the association of -401C/T and +452C/T polymorphisms of gamma-glutamyl hydrolase and the risk of relapse to acute lymphoblastic leukemia. Genotyping was performed in 70 children with acute lymphoblastic leukemia and 140 healthy children. An association between the -401C/T polymorphism and the risk...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.11.027
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The median survival of patients with chronic myelogenous leukemia in myeloid blast crisis (MBC-CML) is poor even for patients treated with tyrosine kinase inhibitors (TKIs). DESIGN AND METHODS:We conducted a dose-escalating study of daunorubicin combined to fixed doses of IM (imatinib mesylate, 600 mg/d) an...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.leukres.2010.11.004
更新日期:2011-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.11.007
更新日期:2008-06-01 00:00:00