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Establishment and characterization of a B-cell line from a patient with acute lymphoblastic leukemia.

Abstract：

:A permanent lymphoblastoid cell line was established from the peripheral blood of a child with acute lymphoblastic leukemia. The cell line, designated SDK, grows in a stationary suspension culture, forming aggregates, in RPMI medium supplemented with 10% FCS, with a doubling time of 50-60 h. Immunologic markers and cytological features suggested that the SDK cells should be identified as being of B-cell origin. The cells failed to form rosettes with sheep erythrocytes, did not express T-cell antigens as defined by monoclonal antibodies, and exhibited surface and cytoplasmic immunoglobulin determinants. Chromosome analysis revealed the presence of three cell populations with (a) 46XY; (b) t(8q-; 14q+) or 2p-; 14q+) and (c) cells with unidentifiable markers. SDK demonstrated susceptibility to TPA-induced differentiation toward plasma cells.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Kottaridis S,Perez S,Kokkinopoulos D,Delinassios JG,Pangalis GA,Cosmidis H,Goula I,Papamichail M

doi

10.1016/0145-2126(85)90025-6

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

113-22

issue

1

eissn

0145-2126

issn

1873-5835

journal_volume

9

pub_type

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