Bone and bone-marrow interactions: haematological activity of osteoblastic growth peptide (OGP)-derived carboxy-terminal pentapeptide. Mobilizing properties on white blood cells and peripheral blood stem cells in mice.

abstract：:Immunophenotypic classification of the acute leukemias (AcL) is of well documented value in those of lymphoid or uncertain origin and of increasing importance in those of nonlymphoid origin. Most of these studies have been performed on viable cell suspensions. To study the efficacy of a simpler immunohistochemical app...

journal_title：Leukemia research

authors： Vago JF,Hurtubise PE,Martelo OJ,Swerdlow SH

更新日期：1987-01-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is a widely used prototypical chemical inducer of cell differentiation. In the present study, the effects of DMSO on susceptibility of human myeloid leukemia U937 cells towards ligation of distinct death receptors (DRs) were investigated. DMSO sensitized cells towards induction of apoptosis b...

journal_title：Leukemia research

authors： Vondrácek J,Soucek K,Sheard MA,Chramostová K,Andrysík Z,Hofmanová J,Kozubík A

更新日期：2006-01-01 00:00:00

abstract：:Inosine 5'-monophosphate (IMP) dehydrogenase catalyzes the rate-limiting reaction of guanine nucleotide biosynthesis and has been implicated in the reaction of cell growth and differentiation. We investigated the ability of mycophenolate mofetil, a prodrug of mycophenolic acid, to induce differentiation in HL-60 and U...

journal_title：Leukemia research

authors： Inai K,Tsutani H,Yamauchi T,Fukushima T,Iwasaki H,Imamura S,Wano Y,Nemoto Y,Naiki H,Ueda T

更新日期：2000-09-01 00:00:00

abstract：:Zerumbone (ZER) is a potential anticancer natural compound, isolated from Zingiber zerumbet Smith. In this investigation, the anticancer properties of ZER were evaluated on cancer cells of T-acute lymphoblastic leukemia, CEM-ss. The results showed that ZER has cytotoxic effect against CEM-ss cells with an IC(50) of 8....

journal_title：Leukemia research

authors： Abdelwahab SI,Abdul AB,Mohan S,Taha MM,Syam S,Ibrahim MY,Mariod AA

更新日期：2011-02-01 00:00:00

abstract：:Pyothorax-associated lymphoma (PAL) is a representative form of diffuse large B-cell lymphoma associated with chronic inflammation, in which the Epstein-Barr virus (EBV) genome is consistently detectable in the lymphoma cells of all PAL cases. Cell lines and animal models would be useful for understanding better this ...

journal_title：Leukemia research

authors： Taniguchi A,Hashida Y,Nemoto Y,Taguchi T,Iwahara Y,Daibata M

更新日期：2013-11-01 00:00:00

abstract：:Bone marrow cells of five patients with acute myeloid leukemia were fractionated by means of counterflow centrifugation (elutriation). The different fractions were enriched with cells belonging to subsequent stages of the cell cycle. Cytokinetic evaluation of these cell fractions was performed by [3H]thymidine autorad...

journal_title：Leukemia research

authors： Vierwinden G,Drenthe-Schonk AM,Plas AM,Linssen PC,Pennings AH,Holdrinet RS,van Egmond J,Wessels JM,Haanen CA

更新日期：1982-01-01 00:00:00

abstract：:The oral bacterium, Aggregatibacter actinomycetemcomitans, produces a leukotoxin (LtxA) that is specific for white blood cells (WBCs) from humans and Old World primates by interacting with lymphocyte function antigen-1 (LFA-1) on susceptible cells. To determine if LtxA could be used as a therapeutic agent for the trea...

journal_title：Leukemia research

authors： Kachlany SC,Schwartz AB,Balashova NV,Hioe CE,Tuen M,Le A,Kaur M,Mei Y,Rao J

更新日期：2010-06-01 00:00:00

abstract：:Apoptosis resistance is an important mechanisms of drug resistance mediated by bone marrow stromal cells (BMSCs). BMSCs influence tumor cells survival through several mechanisms including direct cell-cell contact and the effects of soluble factors. In this research we investigated the role of X-linked inhibitor of apo...

journal_title：Leukemia research

authors： Wang X,Wang C,Yan SK,Gao YR

更新日期：2007-08-01 00:00:00

abstract：:A t(14;18) translocation is closely associated with the follicular lymphoma but is also seen in diffuse B cell lymphomas with a previous history of a follicular lymphoma as well as de novo diffuse lymphomas. Estimation of the frequency of t(14;18) in follicular lymphoma vary widely from 33 to 89%. Furthermore, no exte...

journal_title：Leukemia research

authors： Sayhan N,Tuzuner N,Aki H,Demir G,Berkarda B

更新日期：2000-06-01 00:00:00

abstract：:We compared the efficacy and toxicity of BEAM (BCNU, etoposide, cytarabine and melphalan) and BuCyE (busulfan, cyclophosphamide and etoposide), given prior to autologous stem cell transplantation (ASCT), in 65 patients with non-Hodgkin's lymphoma. Of these 65 patients, 43 received BEAM and 22 received BuCyE. Their age...

journal_title：Leukemia research

authors： Kim JE,Lee DH,Yoo C,Kim S,Kim SW,Lee JS,Park CJ,Huh J,Suh C

更新日期：2011-02-01 00:00:00

abstract：:A new cell line, designated MO1043, was established from the peripheral blood (PB) of a patient with B-cell chronic lymphocytic leukemia (CLL). Both the PB leukemia cells and MO1043 were found to have an abnormal cytogenetic marker of trisomy 12, the most common cytogenetic abnormality in CLL. In addition, both the PB...

journal_title：Leukemia research

authors： Kawata A,Han T,Dadey B,Weier HU,Okazaki M,Yokota S,Fukiage T,Xiao H,Block AM,Barcos M

更新日期：1993-10-01 00:00:00

abstract：:The incidence of B cell chronic lymphocytic leukemia (B-CLL) is lower in Asian countries, including India, when compared with Western countries. The bcl-2 gene rearrangement was restricted to the 5' region and seen in only one of the 20 Indian patients analyzed. The incidence remains similar to that reported from West...

journal_title：Leukemia research

authors： Parikh PM,Desai S,Naresh KN,Shakuntaka B,Laxminarayan K,Nair CN,Ladanyi M,Soman CS,Advani SH,Chaganti RS

更新日期：1996-09-01 00:00:00

abstract：:We have previously shown that heparin and heparan sulfate stimulate the growth of human erythroleukemia cells in vitro in the presence of serum or plasma. To determine whether heparin and other glycosaminoglycans (GAGs) are involved in the growth of leukemia cells, effects of GAGs on the growth of three leukemia cell ...

journal_title：Leukemia research

authors： Maurer AM,Han ZC,Dhermy D,Brière J

更新日期：1994-11-01 00:00:00

abstract：:Endonucleases capable of producing internucleosomal DNA cleavage are one of the key enzymes in apoptosis. We examined endonuclease activities contained in nuclei of CD34+ and erythroid cells in the bone marrow (BM) from 12 patients with the myelodysplastic syndromes. The levels of Mg(2+)-dependent and acidic endonucle...

journal_title：Leukemia research

authors： Anzai N,Kawabata H,Hishita T,Yoshida Y,Ueda Y,Okuma M

更新日期：1997-08-01 00:00:00

abstract：:We established a plasmacytoid dendritic cell (pDC) line (PMDC05) from leukemia cells of pDC leukemia. PMDC05 cells were positive for CD4, CD56, CD33, HLA-DR, CD123 (IL-3Ralpha) and CD86 in the absence of lineage markers. mRNA of TLR1, TLR2, TLR4, TLR7 and TLR9 was clearly expressed and among these TLRs, TLR7 was promi...

journal_title：Leukemia research

authors： Narita M,Watanabe N,Yamahira A,Hashimoto S,Tochiki N,Saitoh A,Kaji M,Nakamura T,Furukawa T,Toba K,Fuse I,Aizawa Y,Takahashi M

更新日期：2009-09-01 00:00:00

abstract：:The study was undertaken to elucidate the regulatory roles of GMP reductase (GMPR) and IMP dehydrogenase (IMPDH) on purine interconversion during differentiation. Treatment of HL-60 cells with retinoic acid (1 microM) induced granulocytic differentiation which was accompanied with a 2.4-fold increase in GMPR and 55% d...

journal_title：Leukemia research

authors： Nakamura H,Natsumeda Y,Nagai M,Takahara J,Irino S,Weber G

更新日期：1992-06-01 00:00:00

abstract：:Because of the teratogenicity data in rats, it is recommended that women treated with imatinib should be aware of the potential teratogenicity of imatinib and effective contraception should be used during imatinib therapy to prevent pregnancy. We describe successful pregnancy and delivery, without any congenital anoma...

journal_title：Leukemia research

authors： Ali R,Ozkalemkaş F,Ozçelik T,Ozkocaman V,Ozan U,Kimya Y,Köksal N,Gülten T,Yakut T,Tunali A

更新日期：2005-08-01 00:00:00

abstract：:In previous studies, HL60 AML cells treated with tumor necrosis factor-alpha (TNF), interferon-gamma (IFN), and lipopolysaccharides (LPS) displayed decreased growth and viability, enhanced monocytic pathway differentiation and endogenous TNF release. Endogenous TNF release by LPS/TNF/IFN treated HL60 cells was postula...

journal_title：Leukemia research

authors： Treon SP,Anand B,Ulevitch R,Broitman SA

更新日期：1994-01-01 00:00:00

abstract：:Nitric oxide (NO) has been shown to be cytotoxic for normal and transformed cell lines. One of the intracellular targets for NO action is glutathione (GSH). GSH determinates cellular redox potential and modulates several biological events. During oxidative and nitrosative stress, glutathione system imbalance is associ...

journal_title：Leukemia research

authors： Santos-Silva MC,Freitas MS,Assreuy J

更新日期：2006-02-01 00:00:00

abstract：:Aggressive chemotherapy of myelodysplastic syndromes is rarely feasible because these disorders predominantly occur in elderly patients who often have concurrent illnesses. Alternative treatment modalities must therefore be evaluated. This review summarizes the results that have been obtained with low-dose chemotherap...

journal_title：Leukemia research

authors： Aul C,Gattermann N

更新日期：1992-01-01 00:00:00

abstract：:Smoking may be associated with accelerated erythropoiesis, leukocytosis and thrombocytosis, which are also hallmarks in patients with polycythemia vera, essential thrombocythemia and early stages of myelofibrosis (MPNs). The JAK-STAT and NF-κB signaling pathways are activated in both smokers and in patients with MPNs....

journal_title：Leukemia research

authors： Hasselbalch HC

更新日期：2015-09-09 00:00:00

abstract：BACKGROUND:The Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are associated with increases in janus kinase 2 (JAK2) signaling, often resulting from the JAK2 V617F mutation. LY2784544 (gandotinib) is a potent, selective, small-molecule inhibitor of JAK2 that has potential dose-dependent selectivit...

journal_title：Leukemia research

authors： Berdeja J,Palandri F,Baer MR,Quick D,Kiladjian JJ,Martinelli G,Verma A,Hamid O,Walgren R,Pitou C,Li PL,Gerds AT

更新日期：2018-08-01 00:00:00

abstract：:We employed a liquid culture system to examine the in vitro effects of vincristine and vindesine on cellular incorporation of 35SO4 into leukemic cells obtained from 5 patients with chronic granulocytic leukemia in blast crisis. The per cent of 35SO4 into drug-treated as compared to saline-treated leukemic cells was c...

journal_title：Leukemia research

authors： Theodorakis ME,Goldberg J

更新日期：1984-01-01 00:00:00

abstract：:The acid phosphatase (AP), beta-glucuronidase (BG), and alpha-naphthyl-acetate esterase (ANAE) distribution and the morphology of stage 0 B-CLL lymphocytes were studied. The results were compared with the same hydrolase equipment and morphology of normal B-cell populations showing the B-CLL-like phenotype, and thus re...

journal_title：Leukemia research

authors： Palestro G,Novero D,Godio L,Micca FB,Resegotti L,Stramignon A

更新日期：1987-01-01 00:00:00

abstract：:The impact of genetic aberrations on rituximab-based therapeutic regimens has been intensely studied in chronic lymphocytic leukemia (CLL). According to the current consensus chemoimmunotherapy consisting of rituximab and DNA-damaging drugs is not suitable for patients with TP53 defects. In our study, we focused on CL...

journal_title：Leukemia research

authors： Spunarova M,Tom N,Pavlova S,Mraz M,Brychtova Y,Doubek M,Panovska A,Skuhrova Francova H,Brzobohata A,Pospisilova S,Mayer J,Trbusek M

更新日期：2019-06-01 00:00:00

abstract：:Chromosomal changes are necessary in determining the classification, prognosis and using the appropriate therapeutic regimen in acute leukemia. Isochromosomes are uncommon chromosome aberations in childhood acute lymphoblastic leukemia (ALL) and the effect of i(9q) is not well established. We present an 8-year-old mal...

journal_title：Leukemia research

authors： Cogulu O,Karapinar DY,Karaca E,Aydinok Y,Ozkinay F

更新日期：2006-11-01 00:00:00

abstract：:Leukemic cell apoptosis may be enhanced by appropriate oxidative stress. We report here the mechanism of Jurkat cell apoptosis by monochloramine (NH(2)Cl), a neutrophil-derived oxidant. NH(2)Cl induced caspase-dependent apoptosis, which was preceded by cytochrome c and Smac/Diablo release from mitochondria. Within 10m...

journal_title：Leukemia research

authors： Ogino T,Ozaki M,Hosako M,Omori M,Okada S,Matsukawa A

更新日期：2009-01-01 00:00:00

abstract：:Hybrid (C56BL/6 x DBA) (BDF1; H-2b/H-2d) mice bearing the P815 leukemia (H-2d) were grafted with a (CBA x C57BL/6)F1 (CBF1; H-2k/H-2b) cell suspension, comprising bone marrow cells (BMC; 25 x 10(6)/mouse) and spleen cells (SC; 55 x 10(6)/mouse) on day-4, then treated with cyclophosphamide (200 mg/kg) on day-2 and fina...

journal_title：Leukemia research

authors： Seledtsov VI,Seledtsova GV,Avdeev EV,Samarin DM,Kozlov VA

更新日期：1997-10-01 00:00:00

abstract：:Brazil is a wide country with huge contrasts. Its peculiarities can highlight environmental factors that could influence the frequencies of different cancers. The standard treatment and results achieved from several different areas of the country may not be found in others. The establishment of a national cooperative ...

journal_title：Leukemia research

authors： Lopes LF,Lorand-Metze I,Niero-Melo L,Tone LG,Velloso E,Campanaro CM,Latorre Mdo R

更新日期：2002-07-01 00:00:00

abstract：:Testis-specific gene antigen (TSGA10) is expressed in fetus, testis and frequently in human solid cancers and acute leukemias, making it a candidate for immunotherapy and for detection of minimal residual disease (MRD). This gene is considered as a member of cancer-testis (CT) genes. We previously demonstrated TSGA10 ...

journal_title：Leukemia research

authors： Mobasheri MB,Modarressi MH,Shabani M,Asgarian H,Sharifian RA,Vossough P,Shokri F

更新日期：2006-07-01 00:00:00