Abstract:
:Testis-specific gene antigen (TSGA10) is expressed in fetus, testis and frequently in human solid cancers and acute leukemias, making it a candidate for immunotherapy and for detection of minimal residual disease (MRD). This gene is considered as a member of cancer-testis (CT) genes. We previously demonstrated TSGA10 expression during spermatogenesis. There is also evidence for potential TSGA10 involvement in cell proliferation. TSGA10 expression has been observed in a wide spectrum of cancers but not in hematopoietic neoplasm. Here we demonstrated expression of TSGA10 by semi-quantitative RT-PCR in 44 (84.6%) out of 52 bone marrow samples and all peripheral blood samples from patients with acute lymphoblastic leukemia (ALL). Twenty-seven (52%) cases had high level of gene expression and 16 (30.7%) cases had a lower expression level of the gene in the patients bone marrow. Presence of TSGA10 expression in ALL may open a window to functional study of mitotic checkpoint proteins in leukemia. RT-PCR of TSGA10 may help in detection of residual clonal cells leading to early diagnosis and better prognostic qualification of the disease.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Mobasheri MB,Modarressi MH,Shabani M,Asgarian H,Sharifian RA,Vossough P,Shokri Fdoi
10.1016/j.leukres.2005.11.012keywords:
subject
Has Abstractpub_date
2006-07-01 00:00:00pages
883-9issue
7eissn
0145-2126issn
1873-5835pii
S0145-2126(05)00443-1journal_volume
30pub_type
杂志文章abstract::The aim of this study is to detect the biologic and/or prognostic significance of survivin (S) and effector protease receptor 1: EPR-1 (E) expression in acute leukemias (34 ALL and 40 AML) by using RT-PCR. S and E expressions were found in 83.8 and 20.3% of the cases, respectively. S was detected in 90%, 76.5% and E w...
journal_title:Leukemia research
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更新日期:2007-11-01 00:00:00
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journal_title:Leukemia research
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更新日期:2000-02-01 00:00:00
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
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更新日期:2008-12-01 00:00:00
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doi:10.1016/0145-2126(87)90080-4
更新日期:1987-01-01 00:00:00
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doi:10.1016/0145-2126(86)90087-1
更新日期:1986-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2011.07.016
更新日期:2011-12-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2012.07.004
更新日期:2012-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.06.010
更新日期:2017-09-01 00:00:00
abstract::An acute promyelocytic leukemia in the rat (BNML) has been used in model studies on pathogenesis and therapy of human acute myeloid leukemia. The blood supply to bone marrow during BNML development has hitherto not been examined, even though in general, blood flow to hematopoietic tissues might affect drug treatment a...
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doi:10.1016/0145-2126(93)90071-r
更新日期:1993-08-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2004.11.006
更新日期:2005-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.03.009
更新日期:2009-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2018.03.002
更新日期:2018-05-01 00:00:00
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journal_title:Leukemia research
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doi:10.1016/j.leukres.2012.02.021
更新日期:2012-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/j.leukres.2012.10.016
更新日期:2013-02-01 00:00:00
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更新日期:2020-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2000-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/j.leukres.2013.08.020
更新日期:2013-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2019.106284
更新日期:2020-01-01 00:00:00
abstract::Chemotherapy resistance has been considered as a major problem for multiple myeloma (MM) treatment and bone marrow microenvironment plays a crucial role in the MM progression and chemoresistance. Recent studies reported that bone marrow mesenchymal stem cells derived from MM patients (MM-MSCs) revealed various charact...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.07.002
更新日期:2017-09-01 00:00:00
abstract::Homoharringtonine combined aclarubicin and cytarabine (HAA) has been demonstrated to achieve a high remission rate and provide a survival advantage in acute myeloid leukemia (AML). To investigate whether HAA is an ideal induction regimen for t(8;21)AML, we retrospectively analyzed the data of 140 patients from the las...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2016.02.012
更新日期:2016-05-01 00:00:00
abstract::The results of allogeneic marrow transplantation in 75 patients with acute lymphoblastic leukemia and 63 patients with acute non-lymphoblastic leukemia in relapse are reviewed. The effects of various chemotherapeutic regimens added to the basic regimen of cyclophosphamide (Cy) 60 mg/kg given on each of two successive ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(82)90101-1
更新日期:1982-01-01 00:00:00
abstract::We have previously shown that HL-60 cells exposed to all-trans retinoic acid (ATRA) after treatment with a non-cytotoxic concentration of vincristine (VCR) result in granulocytic maturation and differentiation, suggesting that VCR might exhibit a synergistic action with ATRA in the treatment of acute promyelocytic leu...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(96)00090-2
更新日期:1997-01-01 00:00:00
abstract::Immunoglobulin gene rearrangements can be used as genetic markers of clonality in the study of B-cell populations [4]. We have therefore analysed the structure and expression of heavy and light chain immunoglobulin genes in lymphocytes of a patient with chronic lymphocytic leukemia, where we found both k and lambda pr...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90162-7
更新日期:1987-01-01 00:00:00
abstract::The aim of the study was to investigate the expression of MIP-1 alpha and sclerostin in bone marrow of patients with multiple myeloma (MM), the possible association of the sclerostin and MIP-1 alpha with MBD and the clinical characteristics. 53 patients (29 M, 24 F), median age 64 years was studied. MIP-1 alpha, scler...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2014.02.010
更新日期:2014-05-01 00:00:00