当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > Bone marrow plasma macrophage inflammatory protein protein-1 alpha(MIP-1 alpha) and sclerostin in multiple myeloma: relationship with bone disease and clinical characteristics.

Bone marrow plasma macrophage inflammatory protein protein-1 alpha(MIP-1 alpha) and sclerostin in multiple myeloma: relationship with bone disease and clinical characteristics.

Abstract：

:The aim of the study was to investigate the expression of MIP-1 alpha and sclerostin in bone marrow of patients with multiple myeloma (MM), the possible association of the sclerostin and MIP-1 alpha with MBD and the clinical characteristics. 53 patients (29 M, 24 F), median age 64 years was studied. MIP-1 alpha, sclerostin and bone-specific alkaline phosphatase (bALP) levels were quantified using an enzyme-linked immunosorbent assay (ELISA). Sclerostin and MIP-1 alpha mRNA expression was determined by RT-PCR. PTH and 1,25(OH) 2D3 levels were measured with an electrochemiluminescence immunoassay. The sclerostin and MIP-1 alpha concentrations in patients with MM were higher than those in the controls. RT-PCR analysis verified that the bone marrow mononuclear cells (BMMNCs) of most patients showed sclerostin and MIP-1 alpha mRNA expression. The sclerostin and MIP-1 alpha levels in patients with ISS stage III disease were significantly higher than those in patients with ISS stage II disease (p=0.01 and 0.06). The sclerostin and MIP-1 alpha levels in patients with BMD in group C were significantly higher than those in group A+B. There was positive correlation between sclerostin levels and MIP-1 alpha, beta2-microglobulin and aCa levels. A negative association was seen between sclerostin levels and bALP, HB and ALB levels. The MM patients with high sclerostin levels (>0.72 ng/ml) had significantly shorter median survival than those with low sclerostin levels (≤0.72 ng/ml) (χ(2)=7.574, p=0.006). Our findings support the positive relationship between sclerostin levels and MIP-1alpha levels deserve further detailed research.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Wang XT,He YC,Zhou SY,Jiang JZ,Huang YM,Liang YZ,Lai YR

doi

10.1016/j.leukres.2014.02.010

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

525-31

issue

5

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(14)00059-9

journal_volume

38

pub_type

杂志文章

相关文献

LEUKEMIA RESEARCH文献大全
  • Combination of erythropoietin and thalidomide for the treatment of anemia in patients with myelodysplastic syndromes.

    abstract：:We investigated the therapeutic activity of recombinant erythropoietin (r-EPO) in association with thalidomide in 30 patients with myelodysplastic syndromes (MDS), previously treated with r-EPO (n.15, group A) or thalidomide (n.15, group B) as single agents, respectively, without any significant benefit on their anemi...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.08.020

    authors： Musto P,Falcone A,Sanpaolo G,Bodenizza C

    更新日期：2006-04-01 00:00:00

  • Pycnogenol induces differentiation and apoptosis in human promyeloid leukemia HL-60 cells.

    abstract：:Pycnogenol, rich of many phytochemicals of medical value, is a commercialized nutrient supplement extracted from the bark of European coastal pine. In this study, we investigated the anti-tumor effects of Pycnogenol on HL-60, U937 and K562 human leukemia cell lines. We found that Pycnogenol inhibited cell proliferatio...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2004.10.006

    authors： Huang WW,Yang JS,Lin CF,Ho WJ,Lee MR

    更新日期：2005-06-01 00:00:00

  • Intracellular accumulation of cytosine arabinoside in murine normal and neoplastic lymphocytes following their exposure to sodium 2-mercaptoethanesulphonate.

    abstract：:The effect of mesna on intracellular accumulation of cytosine arabinoside (Ara-C) in murine normal and neoplastic lymphocytes was studied. Simultaneous exposure of cells to mesna at concentrations ranging from 0.25 to 1.0 mM and 3H-Ara-C (40.0 nM) resulted in a strong inhibition of Ara-C uptake in normal lymphocytes. ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(93)90117-4

    authors： Jastrzebski Z,Czyzewska-Szafran H,Remiszewska M,Côte-Rozanes C

    更新日期：1993-09-01 00:00:00

  • An in vitro study of blast cell metabolism in acute myeloid leukaemia using the MTT assay.

    abstract：:We have utilized the MTT assay to measure the metabolic activity of cells from the bone marrow of 55 patients with acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS) and non-clonal disease. Doubling dilutions of cells were exposed to MTT for 3-4 h. The mean optical density of the formazan produced by each c...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(95)00163-8

    authors： Elgie AW,Sargent JM,Taylor CG,Williamson C

    更新日期：1996-05-01 00:00:00

  • Improving risk-stratification of patients with chronic lymphocytic leukemia using multivariate patient similarity networks.

    abstract：BACKGROUND:Better risk-stratification of patients with chronic lymphocytic leukemia (CLL) and identification of subsets of ultra-high-risk (HR)-CLL patients are crucial in the contemporary era of an expanded therapeutic armamentarium for CLL. METHODS:A multivariate patient similarity network and clustering was applied...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2019.02.005

    authors： Turcsanyi P,Kriegova E,Kudelka M,Radvansky M,Kruzova L,Urbanova R,Schneiderova P,Urbankova H,Papajik T

    更新日期：2019-04-01 00:00:00

  • Synergy of FLT3 inhibitors and the small molecule inhibitor of LIM kinase1/2 CEL_Amide in FLT3-ITD mutated Acute Myeloblastic Leukemia (AML) cells.

    abstract：:Patients with FLT3-ITD mutated (FLT3-ITD+) Acute Myeloid Leukemia (AML), have frequently relapsed or refractory disease and FLT3-ITD+ inhibitors have limited efficacy. Rho kinases (ROCK) are constitutively activated by FLT3-ITD+ in AML via PI3 kinase and Rho GTPase. Upon activation by ROCK, LIM kinases (LIMK) inactiva...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2020.106490

    authors： Djamai H,Berrou J,Dupont M,Kaci A,Ehlert JE,Weber H,Baruchel A,Paublant F,Prudent R,Gardin C,Dombret H,Braun T

    更新日期：2020-12-13 00:00:00

  • A combination of thalidomide and arsenic trioxide is effective and well tolerated in patients with myelodysplastic syndromes.

    abstract：:Twenty-two patients with myelodysplastic syndromes (MDS) were treated with thalidomide plus arsenic trioxide (ATO). Twenty-two MDS patients receiving supportive care were used as controls. The remission was achieved in 4 patients (18.2%) receiving thalidomide/ATO, and none in the control group (p<0.05). Fifteen of 22 ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2011.12.023

    authors： Wei W,Zhou F,Zhang Y,Guo L,Shi H,Hou J

    更新日期：2012-06-01 00:00:00

  • Sustained disease control in transplant-ineligible patients: the role of continuous therapy.

    abstract：:Many patients with multiple myeloma (MM) are elderly (aged >65 years) or unfit, and therefore ineligible for stem-cell transplantation. The novel agents thalidomide, bortezomib, and lenalidomide have shown improved outcomes in these patients. This article discusses the role of continuous therapy in improving patient o...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/S0145-2126(12)70005-X

    authors： Palumbo A,Niesvizky R

    更新日期：2012-11-01 00:00:00

  • Response to therapy with interferon alpha-2b and prednisolone in aggressive systemic mastocytosis: report of five cases and review of the literature.

    abstract：:Aggressive systemic mastocytosis (ASM) is a hematopoietic neoplasm characterized by infiltration of visceral organs by neoplastic mast cells (MCs) with consecutive organopathy and respective clinical and laboratory findings (so called C-Findings). Whereas, it is generally appreciated that patients with ASM are candida...

    journal_title：Leukemia research

    pub_type： 杂志文章,评审

    doi：10.1016/s0145-2126(03)00259-5

    authors： Hauswirth AW,Simonitsch-Klupp I,Uffmann M,Koller E,Sperr WR,Lechner K,Valent P

    更新日期：2004-03-01 00:00:00

  • Transfer of the cytidine deaminase cDNA into hematopoietic cells.

    abstract：:In order to investigate whether transfer of the cytidine deaminase (CDD) cDNA would increase chemotherapy resistance to cytosine arabinoside (ara-C) we used a retroviral vector expressing both, neomycin phosphotransferase and the CDD cDNA, to transduce hematopoietic cells from cell lines and from murine bone marrow (B...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(99)00128-9

    authors： Flasshove M,Frings W,Schröder JK,Moritz T,Schütte J,Seeber S

    更新日期：1999-11-01 00:00:00

  • Differences in the distribution of subtypes according to the WHO classification 2008 between Japanese and German patients with refractory anemia according to the FAB classification in myelodysplastic syndromes.

    abstract：:We reported the different clinical features between Japanese and German refractory anemia (RA) patients in FAB classification. We re-analyzed the clinical features by WHO classification revised in 2008. The frequencies of refractory cytopenia with unilineage dysplasia (RCUD) and myelodysplastic syndrome-unclassified (...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2009.11.015

    authors： Matsuda A,Germing U,Jinnai I,Araseki K,Kuendgen A,Strupp C,Iwanaga M,Miyazaki Y,Hata T,Bessho M,Gattermann N,Tomonaga M

    更新日期：2010-08-01 00:00:00

  • Analysis of clonality at the level of progenitors in chronic myelogenous leukaemia using the polymerase chain reaction.

    abstract：:The Philadelphia (Ph1) chromosome is a specific structural abnormality in which the abl oncogene is activated due to the formation of the novel chimeric gene, bcr/abl. To investigate the clinicopathological role of bcr/abl in Ph1-positive chronic myelogenous leukaemia (CML), we studied the clonal origin of haematopoie...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(92)90139-x

    authors： Sadamura S,Umemura T,Takahira H,Hirata J,Nishimura J,Nawata H

    更新日期：1992-01-01 00:00:00

  • Imatinib mesylate discontinuation in patients with chronic myeloid leukemia who have received front-line imatinib mesylate therapy and achieved complete molecular response.

    abstract：:The aims were to investigate the feasibility of imatinib mesylate (IM) discontinuation in chronic myeloid leukemia patients who were initially treated with IM and achieved complete molecular response (CMR). Fourteen patients were included. Ten were relapsed within 9.5 months after discontinuation of IM. All 7 patients...

    journal_title：Leukemia research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.leukres.2012.02.011

    authors： Yhim HY,Lee NR,Song EK,Yim CY,Jeon SY,Shin S,Kim JA,Kim HS,Cho EH,Kwak JY

    更新日期：2012-06-01 00:00:00

  • Identification of a novel, tissue-specific ABCG2 promoter expressed in pediatric acute megakaryoblastic leukemia.

    abstract：:ABCG2 encodes a transporter protein that is associated with multidrug-resistant phenotypes in many cancers, including acute myeloid leukemia (AML); high levels of expression are generally associated with a poor prognosis. To better understand how expression of ABCG2 is controlled in pediatric AML, we performed a detai...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2011.05.004

    authors： Campbell PK,Zong Y,Yang S,Zhou S,Rubnitz JE,Sorrentino BP

    更新日期：2011-10-01 00:00:00

  • Effects of recombinant G-CSF and GM-CSF on the growth in methylcellulose and suspension of the blast cells in acute myeloblastic leukemia.

    abstract：:The effects of two recombinant human CSFs (G-CSF and GM-CSF) on the growth of blast progenitors from 36 acute myeloblastic leukemia patients were studied in methylcellulose and suspension cultures. Blast colony formation in methylcellulose and the growth of blast progenitors in suspension were stimulated by G-CSF or G...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(88)90063-x

    authors： Murohashi I,Nagata K,Suzuki T,Maruyama Y,Nara N

    更新日期：1988-01-01 00:00:00

  • Myelodysplastic syndrome with transformation to acute monocytic leukemia with FLT3-ITD mutation following orthotopic liver transplantation.

    abstract：:A rare case of a 46-year-old man who underwent myelodysplastic syndrome, acute monocytic leukemia with FLT3-ITD mutation and splenic disruption following orthotopic liver transplantation is reported. The study of this case may be helpful to understand both the pathogenesis of acute leukemia and new complication of liv...

    journal_title：Leukemia research

    pub_type： 信件

    doi：10.1016/j.leukres.2005.11.025

    authors： Zhang GS,Dai CW,Peng HL,Xu YX,Pei MF

    更新日期：2006-07-01 00:00:00

  • A diphtheria toxin interleukin-3 fusion protein synergizes with tyrosine kinase inhibitors in killing leukemic progenitors from BCR/ABL positive acute leukemia.

    abstract：:Despite initial remissions, most patients with Ph chromosome positive (Ph(+)) acute leukemia (AL) become refractory to tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib. This study was designed to determine if targeting the interleukin-3 receptor (IL-3R) with a diphtheria toxin fusion protein (DT(388)IL...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2009.12.008

    authors： Kim HP,Frankel AE,Hogge DE

    更新日期：2010-08-01 00:00:00

  • Transcriptional profiling and assessment of cell lines as in vitro models for mantle cell lymphoma.

    abstract：:Mantle cell lymphoma (MCL) is an aggressive malignancy and new treatment modalities must be established to increase patient survival time. In the search for new therapeutic targets, reliable and well-characterised in vitro models are essential. In this study, we have characterised three MCL cell lines (SP53, Granta 51...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2004.06.009

    authors： Ek S,Ortega E,Borrebaeck CA

    更新日期：2005-02-01 00:00:00

  • Expression of Id2 and Id3 mRNA in human lymphocytes.

    abstract：:Helix-loop-helix (HLH) transcription factors are involved in cellular growth and differentiation. The Id (inhibitor of DNA binding and differentiation) HLH proteins, in a dominantly negative fashion, regulate transcriptional activities of basic HLH proteins. We examined by northern hybridization the expression of Id2 ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(95)00084-4

    authors： Ishiguro A,Spirin K,Shiohara M,Tobler A,Norton JD,Rigolet M,Shimbo T,Koeffler HP

    更新日期：1995-12-01 00:00:00

  • Difference in effects of interferon-alpha and interferon-gamma on the induction of differentiation of retinoic acid-treated acute myeloid leukemia cells in primary culture.

    abstract：:We studied differentiation inducing effects of retinoic acid (RA), 1 alpha, 25-dihydroxyvitamin D3 (D3) and interferons (IFNs), alone and in combination, on fresh myeloid leukemic cells from 8 patients. RA not only induced the differentiation of leukemic cells in 5/8 cases, but potentiated differentiation by IFNs eith...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(90)90072-h

    authors： Nakamaki T,Sakashita A,Hino K,Suzuki K,Tomoyasu S,Tsuruoka N,Honma Y,Hozumi M

    更新日期：1990-01-01 00:00:00

  • Day 22 of induction therapy is important for minimal residual disease assessment by flow cytometry in childhood acute lymphoblastic leukemia.

    abstract：:This study was aimed to illustrate the significance of minimal residual disease (MRD) assessment on day 22 in childhood acute lymphoblastic leukemia. MRD were measured on day 22, day 36, week 12, month 6 and month 12 by four-color flow cytometry. The 5-year cumulative incidence of relapse was significantly different f...

    journal_title：Leukemia research

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.leukres.2012.03.014

    authors： Xu XJ,Tang YM,Shen HQ,Song H,Yang SL,Shi SW,Xu WQ

    更新日期：2012-08-01 00:00:00

  • Synergistic effect of methotrexate and 1-beta-D-arabinofuranosylcytosine on the generation of DNA strand breaks in a human promyelocytic leukemia cell line.

    abstract：:We investigated the accumulation of DNA strand breaks in a human promyelocytic leukemia cell line, HL-60, treated with methotrexate (MTX) and 1-beta-D-arabinofuranosylcytosine (Ara-C). The sequential treatment with MTX then Ara-C had a synergistic effect on the formation of DNA strand breaks, which was dependent on MT...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(89)90139-2

    authors： Tanizawa A,Kubota M,Takimoto T,Kito T,Akiyama Y,Kiriyama Y,Mikawa H

    更新日期：1989-01-01 00:00:00

  • Targeting the IL-17/IL-6 axis can alter growth of Chronic Lymphocytic Leukemia in vivo/in vitro.

    abstract：:The tumor microenvironment (TME) is critical to the longevity of tumor B cells in chronic lymphocytic leukemia (CLL). Bone marrow mesenchymal stem cells (BMMSCs) and the cytokines they produce including IL-6 are important components of the TME in CLL. We found BMMSCs supported the survival of CLL cells in vitro throug...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2018.01.006

    authors： Zhu F,McCaw L,Spaner DE,Gorczynski RM

    更新日期：2018-03-01 00:00:00

  • The combined differentiating effect of retinoic acid and vincristine on acute promyelocytic leukemia.

    abstract：:We have previously shown that HL-60 cells exposed to all-trans retinoic acid (ATRA) after treatment with a non-cytotoxic concentration of vincristine (VCR) result in granulocytic maturation and differentiation, suggesting that VCR might exhibit a synergistic action with ATRA in the treatment of acute promyelocytic leu...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(96)00090-2

    authors： Leung M,Wong K

    更新日期：1997-01-01 00:00:00

  • The expression of PRAME in chronic lymphoproliferative disorders.

    abstract：:The PRAME gene encodes an antigen recognized by autologous T lymphocytes and is expressed in trophoblasts, testis and frequently in human solid cancers and acute leukemias, making it a candidate for immunotherapy and for detecting MRD. We demonstrate expression of PRAME by RT-PCR in the peripheral blood or bone marrow...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(02)00217-5

    authors： Proto-Siqueira R,Falcão RP,de Souza CA,Ismael SJ,Zago MA

    更新日期：2003-05-01 00:00:00

  • Compound 48, a novel dual PPAR alpha/gamma ligand, inhibits the growth of human CML cell lines and enhances the anticancer-effects of imatinib.

    abstract：:Compound 48 (C48) is a novel dual ligand for peroxisome proliferator-activated receptor alpha and gamma (PPAR alpha/gamma). Culture of imatinib-sensitive and -resistant CML cell lines with C48 resulted in a strong growth inhibition which associated with G0/G1 cell cycle arrest. However, it showed no obvious toxicity t...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2008.11.023

    authors： Bertz J,Zang C,Liu H,Wächter M,Possinger K,Koeffler HP,Elstner E

    更新日期：2009-05-01 00:00:00

  • Decreased blood flow to rat bone marrow, bone, spleen, and liver in acute leukemia.

    abstract：:An acute promyelocytic leukemia in the rat (BNML) has been used in model studies on pathogenesis and therapy of human acute myeloid leukemia. The blood supply to bone marrow during BNML development has hitherto not been examined, even though in general, blood flow to hematopoietic tissues might affect drug treatment a...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(93)90071-r

    authors： Iversen PO,Thing-Mortensen B,Nicolaysen G,Benestad HB

    更新日期：1993-08-01 00:00:00

  • Glycosaminoglycans enhance human leukemic cell growth in vitro.

    abstract：:We have previously shown that heparin and heparan sulfate stimulate the growth of human erythroleukemia cells in vitro in the presence of serum or plasma. To determine whether heparin and other glycosaminoglycans (GAGs) are involved in the growth of leukemia cells, effects of GAGs on the growth of three leukemia cell ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(94)90164-3

    authors： Maurer AM,Han ZC,Dhermy D,Brière J

    更新日期：1994-11-01 00:00:00

  • Reciprocal alterations of GMP reductase and IMP dehydrogenase activities during differentiation in HL-60 leukemia cells.

    abstract：:The study was undertaken to elucidate the regulatory roles of GMP reductase (GMPR) and IMP dehydrogenase (IMPDH) on purine interconversion during differentiation. Treatment of HL-60 cells with retinoic acid (1 microM) induced granulocytic differentiation which was accompanied with a 2.4-fold increase in GMPR and 55% d...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(92)90002-o

    authors： Nakamura H,Natsumeda Y,Nagai M,Takahara J,Irino S,Weber G

    更新日期：1992-06-01 00:00:00

  • Erythropoietin activates telomerase through transcriptional and posttranscriptional regulation in human erythroleukemic JAS-REN-A cells.

    abstract：:We evaluated the molecular mechanism of telomerase activation by erythropoietin (EPO) in human erythroleukemic JAS-REN-A cells. Telomerase activity increased 3-4 fold after 3-24h of culture with EPO and was associated with increases in c-myc mRNA after 1-3h, of c-Myc protein after 3-6h, and of human telomerase reverse...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2010.11.002

    authors： Akiyama M,Kawano T,Mikami-Terao Y,Agawa-Ohta M,Yamada O,Ida H,Yamada H

    更新日期：2011-03-01 00:00:00