Abstract:
:Many patients with multiple myeloma (MM) are elderly (aged >65 years) or unfit, and therefore ineligible for stem-cell transplantation. The novel agents thalidomide, bortezomib, and lenalidomide have shown improved outcomes in these patients. This article discusses the role of continuous therapy in improving patient outcomes and how novel agents with better tolerability profiles could lead to a change in the treatment paradigm. According to the proposed concept, treatment of transplant-ineligible patients with MM should include achievement of high-quality responses with effective induction combination regimens, as well as maintenance of the response with long-term therapy for optimal sustained efficacy.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Palumbo A,Niesvizky Rdoi
10.1016/S0145-2126(12)70005-Xsubject
Has Abstractpub_date
2012-11-01 00:00:00pages
S19-26eissn
0145-2126issn
1873-5835pii
S0145-2126(12)70005-Xjournal_volume
36 Suppl 1pub_type
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journal_title:Leukemia research
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journal_title:Leukemia research
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doi:10.1016/0145-2126(84)90090-0
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(82)90050-9
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2004.10.006
更新日期:2005-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2004.08.008
更新日期:2005-04-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2005.08.020
更新日期:2006-04-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90186-x
更新日期:1987-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(88)90098-7
更新日期:1988-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2014.03.017
更新日期:2014-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(02)00175-3
更新日期:2003-04-01 00:00:00
abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.01.006
更新日期:2009-02-20 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(84)90040-7
更新日期:1984-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1999-08-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(93)90117-4
更新日期:1993-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(98)00129-5
更新日期:1999-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2008.12.013
更新日期:2009-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2014.05.008
更新日期:2014-08-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(96)00036-7
更新日期:1996-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.02.002
更新日期:2006-10-01 00:00:00
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journal_title:Leukemia research
pub_type: 评论,社论
doi:10.1016/j.leukres.2008.09.022
更新日期:2009-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.03.035
更新日期:2009-10-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2008.03.036
更新日期:2008-12-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.08.019
更新日期:2008-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.03.010
更新日期:2009-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00077-1
更新日期:1996-04-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2003.09.015
更新日期:2004-05-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00025-x
更新日期:2001-09-01 00:00:00
abstract::Mantle cell lymphoma (MCL) an incurable B-cell, non-Hodgkin lymphoma (NHL) urgently requires new treatments. We assessed reovirus mediated oncolysis in a panel of human MCL cell lines. In vitro, we found the cytopathic effect of reovirus infection ranged from high to very limited and correlated with levels of Ras acti...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.05.020
更新日期:2010-01-01 00:00:00