Very late relapse of chronic myelogenous leukemia after allogeneic bone marrow transplantation.

abstract：:We examined the symptoms and referral rates to specialized palliative care and psychosocial oncology services of patients with acute leukemia. The Memorial Symptom Assessment Scale (MSAS) was completed by 249 adult patients with acute leukemia. Patients reported a median of 9 physical and 2 psychological symptoms, and...

journal_title：Leukemia research

authors： Zimmermann C,Yuen D,Mischitelle A,Minden MD,Brandwein JM,Schimmer A,Gagliese L,Lo C,Rydall A,Rodin G

更新日期：2013-07-01 00:00:00

abstract：:Although there has been much progress in the treatment of acute lymphoblastic leukemia (ALL), decreased sensitivity to chemotherapy remains a significant issue. Recent studies have shown how interactions with the bone marrow microenvironment can protect ALL cells from chemotherapy and allow for the persistence of the ...

journal_title：Leukemia research

authors： Quagliano A,Gopalakrishnapillai A,Barwe SP

更新日期：2017-05-01 00:00:00

abstract：:To study the role of SDF-1/CXCR4 axis in MDS, the expression of SDF-1 and CXCR4, VEGF, MVD and apoptosis were measured in MDS. The results showed that the expression of SDF-1 of the low-grade MDS is higher than that of the high-grade MDS and the control. The high-grade MDS had a significantly higher CXCR4 expression o...

journal_title：Leukemia research

authors： Zhang Y,Zhao H,Zhao D,Sun L,Zhi Y,Wu X,Huang W,Da W

更新日期：2012-03-01 00:00:00

abstract：:C3H/He mice produce myeloid leukemias after whole body irradiation of 1-3Gy as compared with non-irradiated controls that produce fewer than 1% of leukemia [Radiatiton Research 127 (1991) 146]. Thus, p53-deficient C57BL/6 strain, a malignant lymphoma prone, was crossed back into C3H/He strain. Lethally irradiated wild...

journal_title：Leukemia research

authors： Yoshida K,Aizawa S,Watanabe K,Hirabayashi Y,Inoue T

更新日期：2002-12-01 00:00:00

abstract：:The remarkable capacity of the bone marrow to compensate for blood loss and for reduced atmospheric oxygen tension has been found to be mediated by a renal hormone, named erythropoietin. It is produced by peritubular interstitial cells in response to renal hypoxia, but molecular engineering has permitted large scale p...

journal_title：Leukemia research

authors： Erslev AJ

更新日期：1990-01-01 00:00:00

abstract：:In a previous study we reported that a new anthracycline derivative (moflomycin) exhibited a higher antileukemic activity compared to other anthracyclines, such as daunorubicin and doxorubicin. To explain the superior antileukemic effect of moflomycin and to disclose a possible structure-activity relationship, we inve...

journal_title：Leukemia research

authors： Andrivon W,Saucier JM,Auclair C,Monneret C,Florent JC,Guillosson JJ,Nafziger J

更新日期：1996-02-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) cells were cultured in a medium supplemented with 0.01-1 ng/ml interleukin-4 (IL-4) for 18 h, fixed and analyzed on a flow cytometer. The percentage of apoptotic (AP) cells with hypodiploid DNA content was determined from DNA histograms. IL-4 at 0.01 ng/ml protected from spontaneous ...

journal_title：Leukemia research

authors： Frankfurt OS,Byrnes JJ,Villa L

更新日期：1997-01-01 00:00:00

abstract：:Leukotrienes and lipoxins are bioactive lipoxygenase products formed by leukocytes alone or in collaboration with other cells. While the physiological role of lipoxins remains to be clarified, accumulating evidence shows that leukotrienes are important mediators in asthma and inflammation. Consequently, recent clinica...

journal_title：Leukemia research

authors： Stenke L,Reizenstein P,Lindgren JA

更新日期：1994-10-01 00:00:00

abstract：:A panel of human leukemia cell lines from various lineages (T-cell, pre B- and Non-T/Non-B cell, myelomonocytic and erythroleukemia cell lines) were utilised as model systems of the distant effects of differentiation-inducing activity (DIA) produced by the T-leukemia cell line HUT-102. DIA inhibited cell proliferation...

journal_title：Leukemia research

authors： Drexler HG,Notani J,Otsuka K,Gaedicke G,Minowada J

更新日期：1987-01-01 00:00:00

abstract：:We assessed plasma cell proliferation (by propidium iodide index, PC-PI) and apoptosis (by annexin-V index PC-AI) for the estimation of overall survival (OS) in multiple myeloma (MM) patients. 181 patients with newly diagnosed MM were assessed, treated using conventional chemotherapy. The values best discriminating pa...

journal_title：Leukemia research

authors： Minarik J,Scudla V,Ordeltova M,Pika T,Bacovsky J,Steinbach M,Kumar V,Van Ness B

更新日期：2011-01-01 00:00:00

abstract：:We report the development and characterization of SJ-9A4, a monoclonal antibody (MoAb) produced against common acute lymphoblastic leukemia (C-ALL) cell lines. SJ-9A4 reacted with C-ALL, B-cell chronic lymphocytic leukemia (B-CLL), platelets and C-ALL neuroblastoma (NB) and the K562 cell lines. It had no significant r...

journal_title：Leukemia research

authors： Komada Y,Peiper SC,Melvin SL,Metzger DW,Tarnowski BH,Green AA

更新日期：1983-01-01 00:00:00

abstract：:Mutations in Janus kinase 2 (JAK2) are implicated in the pathogenesis of Philadelphia-chromosome negative myeloproliferative neoplasms, including primary myelofibrosis, polycythemia vera, and essential thrombocythemia. Gandotinib (LY2784544), a potent inhibitor of JAK2 activity, shows increased potency for the JAK2V61...

journal_title：Leukemia research

authors： Verstovsek S,Mesa RA,Salama ME,Li L,Pitou C,Nunes FP,Price GL,Giles JL,D'Souza DN,Walgren RA,Prchal JT

更新日期：2017-10-01 00:00:00

abstract：:Our aim was to examine in 17 patients with MDS the effects of PMA activated and non-activated autologous lymphocytes on selected bone marrow CD34+ progenitors, in dose response studies. We used a double layer culture technique. Compared with controls, there was no difference in the colony growth promoting capacity of ...

journal_title：Leukemia research

authors： Davison GM,Novitzky N,Abdulla R

更新日期：2011-09-01 00:00:00

abstract：:Differentiation between reactive bone marrow suppression due to viral infection and early stages of leukemia can be difficult particularly in young infants. We report on a 2-month-old girl presenting with pancytopenia and positive markers for congenital cytomegalovirus (CMV) infection. Definitive diagnosis of coexisti...

journal_title：Leukemia research

authors： Metzler M,Bruch J,Stachel D,Langer T,Borkhardt A,Harbott J,Rascher W,Holter W

更新日期：2007-04-01 00:00:00

abstract：:Normal human peripheral blood polymorphonuclear leukocytes (PMNs) and cells from a human acute promyelocytic leukemia line (HL-60) were tested for cytotoxic potential against two human glioma and one normal fibroblast line. Both the PMNs and HL-60 exhibited significant cytotoxicity against the tumor targets while spar...

journal_title：Leukemia research

authors： Buessow SC,Gillespie GY,Mahaley MS

更新日期：1984-01-01 00:00:00

abstract：:c-Myc has been implicated in a variety of hematologic malignancies including Burkitt's lymphoma. Targeting c-Myc driven growth pathways could be therapeutically useful but might require the identification of critical downstream proteins. Here we show that the serine-threonine kinase PBK/TOPK is frequently overexpresse...

journal_title：Leukemia research

authors： Hu F,Gartenhaus RB,Zhao XF,Fang HB,Minkove S,Poss DE,Rapoport AP

更新日期：2013-04-01 00:00:00

abstract：:To determine the clinical significance of the T helper 1(Th1)/T helper 2 (Th2) ratio in multiple myeloma, the intracellular IFN-gamma and IL-4 were analyzed by flow cytometry in 56 patients with multiple myeloma. The mean Th1/Th2 ratio of cases in the initial diagnosis phase and the refractory phase were higher than t...

journal_title：Leukemia research

authors： Ogawara H,Handa H,Yamazaki T,Toda T,Yoshida K,Nishimoto N,Al-ma'Quol WH,Kaneko Y,Matsushima T,Tsukamoto N,Nojima Y,Matsumoto M,Sawamura M,Murakami H

更新日期：2005-02-01 00:00:00

abstract：:The effect of VM-26, a topoisomerase II targeting drug, on IW32 murine erythroleukemia cells was investigated. The VM-26 induced IW32 cells to differentiate at a non-toxic but cytostatic concentration (0.01 microgram/ml). More than 40% of the cells were induced to synthesize hemoglobin, and cells were arrested in G2/M...

journal_title：Leukemia research

authors： Tan SK,Tang SJ,Wang MC,Hwang J,Wang FF

更新日期：1996-03-01 00:00:00

abstract：:The MTT cell viability assay is widely used in determining drug sensitivity profiles for patients with hematological malignancies and in primary screening of potential chemotherapeutic drugs. Because the multidrug resistance (MDR) phenotype is associated with these malignancies, and since many vital dyes are effluxed ...

journal_title：Leukemia research

authors： Marks DC,Belov L,Davey MW,Davey RA,Kidman AD

更新日期：1992-12-01 00:00:00

abstract：:Like CD19 or CD56, CD22 in non-lymphoid leukemia has been considered an aberrantly expressed antigen. CD22 had been believed to be restricted to B lymphoid, however, it was also found to be expressed in human basophils. Mature basophils are unique granulocytes expressing CD13, CD22 and CD25. To estimate whether the ex...

journal_title：Leukemia research

authors： Sato N,Kishi K,Toba K,Watanabe K,Itoh H,Narita M,Takahashi M,Aizawa Y

更新日期：2004-07-01 00:00:00

abstract：:Bcr-Abl tyrosine kinase inhibitor induces apoptosis and erythroid differentiation of K562 cells. During this erythroid differentiation, c-Myc and cyclin D1 transcripts are transiently downregulated. Accordingly, we studied the effect of cyclin D1 overexpression on erythroid differentiation. After treatment with 250 nM...

journal_title：Leukemia research

authors： Kawano T,Horiguchi-Yamada J,Saito S,Iwase S,Furukawa Y,Kano Y,Yamada H

更新日期：2004-06-01 00:00:00

abstract：:The effect of prostaglandin E2 (PGE2) on the reduction of c-myc expression during the differentiation of the human leukemic cell line, HL-60, was examined. PGE2, a potent inducer of intracellular cyclic AMP (cAMP) in HL-60 cells, augmented monocyte-associated cell surface antigens induced by human gamma-interferon (IF...

journal_title：Leukemia research

authors： Matsui T,Nakao Y,Koizumi T,Katakami Y,Takahashi R,Mihara K,Sugiyama T,Fujita T

更新日期：1988-01-01 00:00:00

abstract：:Older patients with acute myelogenous leukemia (AML) have overexpression of P-glycoprotein (Pgp+), and this has been shown to correlate quantitatively with therapeutic outcome. Since Pgp-mediated efflux of cytotoxic drugs can be inhibited by the cyclosporine analogue, PSC 833, we investigated the use of this agent wit...

journal_title：Leukemia research

authors： Chauncey TR,Rankin C,Anderson JE,Chen I,Kopecky KJ,Godwin JE,Kalaycio ME,Moore DF,Shurafa MS,Petersdorf SH,Kraut EH,Leith CP,Head DR,Luthardt FW,Willman CL,Appelbaum FR

更新日期：2000-07-01 00:00:00

abstract：:We report the case of an elderly patient affected by Philadelphia positive Acute Lymphoblastic Leukaemia (Ph(+) ALL) who developed meningeal leukaemia during imatinib monotherapy, despite bone marrow molecular remission. Aggressive central nervous system (CNS)-directed therapy in combination with continued imatinib tr...

journal_title：Leukemia research

authors： Mele G,Pinna S,Melpignano A,Romano A,Brocca MC,Coppi MR,Quarta G

更新日期：2007-10-01 00:00:00

abstract：:Despite high rates of hematologic and cytogenetic responses to imatinib therapy, the emergence of resistance to imatinib has been recognized as a major problem in the treatment of Ph-positive leukemia. The high frequency of BCR-ABL mutations and amplifications represents the high degree of heterogeneity in patients wi...

journal_title：Leukemia research

authors： Tauchi T,Ohyashiki K

更新日期：2004-05-01 00:00:00

abstract：:Clofarabine (CLO), a purine nucleoside analog with promising efficacy in acute myeloid leukemia (AML), inhibits the ribonucleotidereductase, p53R2. We have shown that p53R2 mRNA is up-regulated by decitabine (DEC), another drug with promising activity in AML. We developed a pharmacodynamic model to characterize the in...

journal_title：Leukemia research

authors： Thudium KE,Ghoshal S,Fetterly GJ,Haese JP,Karpf AR,Wetzler M

更新日期：2012-11-01 00:00:00

abstract：:Increasing evidence suggest that epigenetic mechanisms (e.g. histone modification by histone deacetylases) play a major role in the pathogenesis of Hodgkin's lymphoma (HL). We treated HL cell lines with the histone deacetylase inhibitor vorinostat and investigated the gene expression profile of these cells by using DN...

journal_title：Leukemia research

authors： Kewitz S,Bernig T,Staege MS

更新日期：2012-06-01 00:00:00

abstract：:Total body irradiation (TBI) has traditionally been used in the conditioning regimen for allogenetic hematopoietic stem cell transplantation (alloHCT) from an unrelated donor (u-HCT). However, patients are increasingly receiving a fludarabine-based conditioning regimen without TBI, as it seemed less toxic than TBI. We...

journal_title：Leukemia research

authors： Kim H,Lee KH,Kim I,Sohn SK,Jung CW,Joo YD,Kim SH,Kim BS,Choi JH,Kwak JY,Kim MK,Bae SH,Shin HJ,Won JH,Lee WS,Oh S,Kim HJ,Park JH,Korean Society of Blood and Marrow Transplantation.

更新日期：2014-07-01 00:00:00

abstract：:We used a novel high-throughput drug screening assay, based on Luminex technology, to identify anti-myeloma agents capable of inhibiting cytokines and growth factors essential for multiple myeloma (MM) from a chemical library of 1120 compounds provided by MMRF. Tetracycline derivatives inhibited MM cell proliferation ...

journal_title：Leukemia research

authors： Feng R,Rios JA,Onishi T,Lokshin A,Gorelik E,Lentzsch S

更新日期：2010-07-01 00:00:00

abstract：:The development of risk-adapted therapy has improved the treatment results of acute lymphoblastic leukemia (ALL) especially in children. However, more accurate risk classifiers are warranted. In this study we aimed at defining a prognostic classifier based on DNA copy number alterations of adolescent and young adult (...

journal_title：Leukemia research

authors： Usvasalo A,Elonen E,Saarinen-Pihkala UM,Räty R,Harila-Saari A,Koistinen P,Savolainen ER,Knuutila S,Hollmén J

更新日期：2010-11-01 00:00:00