当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > Simultaneous expression of CD13, CD22 and CD25 is related to the expression of Fc epsilon R1 in non-lymphoid leukemia.

Simultaneous expression of CD13, CD22 and CD25 is related to the expression of Fc epsilon R1 in non-lymphoid leukemia.

Abstract：

:Like CD19 or CD56, CD22 in non-lymphoid leukemia has been considered an aberrantly expressed antigen. CD22 had been believed to be restricted to B lymphoid, however, it was also found to be expressed in human basophils. Mature basophils are unique granulocytes expressing CD13, CD22 and CD25. To estimate whether the expression of CD22 in non-lymphoid leukemia is aberrant or related to basophilic character, we analyzed 108 patients with primary and secondary leukemia. Among non-lymphoid leukemias, surface CD22 expression was more frequently observed in peroxidase-negative AML and secondary leukemia, and was usually observed simultaneously with CD13 and CD25. Samples obtained from 17 cases were further analyzed, and all the Fc epsilon R1-positive cases were observed in peroxidase-negative AML and secondary non-lymphoid leukemia, and mostly expressed CD13, CD22 and CD25. Therefore, surface CD22 expression in non-lymphoid leukemia was thought to relate to basophilic phenotype in some cases. Like CD22, some of the so-called aberrantly expressed antigens may not actually be aberrant, but are expressed in a stage of differentiation and maturation of progenitors. Moreover, CD22 may be one of target molecules for treatment of CD22-positive, poorly prognostic leukemia.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Sato N,Kishi K,Toba K,Watanabe K,Itoh H,Narita M,Takahashi M,Aizawa Y

doi

10.1016/j.leukres.2003.10.034

keywords:

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

691-8

issue

7

eissn

0145-2126

issn

1873-5835

pii

S0145212603003965

journal_volume

28

pub_type

杂志文章

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