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The deacetylase inhibitor LAQ824 induces notch signalling in haematopoietic progenitor cells.

Abstract：

:AML progenitor cells (AML-PC) undergo significant apoptosis in response to the deacetylase inhibitor (DACi) LAQ824 and lose the replating capacity which was not observed with the DACi valproic acid. Treatment of normal hematopoietic progenitor cells (HPC) with LAQ824 resulted in (i) inhibition of differentiation, (ii) an G2/M cell cycle arrest exclusively in multipotent CD34(+) HPC and (iii) induction of apoptosis predominantly in committed CD34(-) HPC. Gene expression analysis showed induction of coactivator and target genes of the notch pathway as well as cell cycle arrest-inducing genes in the most primitive CD34(+) CD38(-) HPC population which may in part be responsible for the considerable, but reversible haematotoxicity of this drug.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Schwarz K,Romanski A,Puccetti E,Wietbrauk S,Vogel A,Keller M,Scott JW,Serve H,Bug G

doi

10.1016/j.leukres.2010.06.024

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

119-25

issue

1

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(10)00316-4

journal_volume

35

pub_type

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