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Stem-cell leukemia: p53 deficiency mediated suppression of leukemic differentiation in C3H/He myeloid leukemia.

Abstract：

:C3H/He mice produce myeloid leukemias after whole body irradiation of 1-3Gy as compared with non-irradiated controls that produce fewer than 1% of leukemia [Radiatiton Research 127 (1991) 146]. Thus, p53-deficient C57BL/6 strain, a malignant lymphoma prone, was crossed back into C3H/He strain. Lethally irradiated wild-type mice to which p53-deficient bone marrow cells were transplanted (transplantation assay) showed dramatic change in the propensity of leukemia of myeloid lineages, the cells lacking CD3, Thy1.2, sIgM, B220, Mac-1, Gr-1, but being positive for c-Kit and CD44. Furthermore, transplanted mice subjected to 3Gy irradiation gave rise to a faster development of leukemia and a higher frequency of double-lineage leukemias than the non-irradiated control.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Yoshida K,Aizawa S,Watanabe K,Hirabayashi Y,Inoue T

doi

10.1016/s0145-2126(02)00032-2

keywords:

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

1085-92

issue

12

eissn

0145-2126

issn

1873-5835

pii

S0145212602000322

journal_volume

26

pub_type

杂志文章

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