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Bone biopsy derived marrow stromal elements rescue chronic lymphocytic leukemia B-cells from spontaneous and drug induced cell death and facilitates an "angiogenic switch".

Abstract：

:A novel bone biopsy technique was used to generate a robust stromal cell system to study how stroma modulates CLL B-cell apoptosis and how the leukemic cell-stromal interaction influences secretion of vascular factors. Marrow stromal elements (MSE) rescued CLL B-cells from both spontaneous and drug induced apoptosis, partly due to soluble factors. When CLL B-cells were added to the MSE cultures, a dramatic increase in the secretion of basic fibroblast growth factor and decrease in the secretion of thrombospondin was observed. These results indicate the interaction between CLL B-cells and marrow stromal elements regulates angiogenic switching and may be linked to disease progression.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Kay NE,Shanafelt TD,Strege AK,Lee YK,Bone ND,Raza A

doi

10.1016/j.leukres.2006.11.024

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

899-906

issue

7

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(06)00461-9

journal_volume

31

pub_type

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