Abstract:
:Oblimersen selectively targets Bcl-2 mRNA and has been shown to enhance the apoptotic activity of various antileukemic agents, including gemtuzumab ozogamicin (GO), in preclinical studies. We evaluated the efficacy and safety of oblimersen combined with GO in patients > or =60 years of age in first relapse with CD33+ acute myeloid leukemia. Oblimersen 7 mg/kg/day was given as a continuous intravenous infusion on days 1-7 and 15-21. GO 9 mg/m2 was given intravenously on days 4 and 18. Twelve of 48 patients (25%) achieved a major response (five, complete response and seven, complete response without platelet recovery). Ten of the 12 patients who achieved a major response survived >6 months compared with six of 36 non-responders. Serious adverse events for the oblimersen/GO combination were qualitatively similar to those reported for GO alone. Oblimersen can be safely combined with GO. Assessment of incremental benefit will require a randomized trial.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Moore J,Seiter K,Kolitz J,Stock W,Giles F,Kalaycio M,Zenk D,Marcucci Gdoi
10.1016/j.leukres.2005.10.025subject
Has Abstractpub_date
2006-07-01 00:00:00pages
777-83issue
7eissn
0145-2126issn
1873-5835pii
S0145-2126(05)00423-6journal_volume
30pub_type
杂志文章,多中心研究abstract::It is generally accepted that morphologically recognizable bone marrow (BM) cells are derived from progenitor cells committed to a specific line of haematopoietic differentiation [51]. The origin and morphological identity of such progenitor cells is not yet known and the question, whether there is a single pluripoten...
journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/0145-2126(85)90130-4
更新日期:1985-01-01 00:00:00
abstract::This study was aimed to illustrate the significance of minimal residual disease (MRD) assessment on day 22 in childhood acute lymphoblastic leukemia. MRD were measured on day 22, day 36, week 12, month 6 and month 12 by four-color flow cytometry. The 5-year cumulative incidence of relapse was significantly different f...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.leukres.2012.03.014
更新日期:2012-08-01 00:00:00
abstract::Flow cytometry is commonly used to establish the diagnosis of chronic lymphocytic leukemia (CLL). A defined combination of antibodies discriminates between normal B cells and CLL cells (coexpression of CD5, CD19, and CD23). The receptor tyrosine-like orphan receptor one (ROR1) is an embryonic glycoprotein involved in ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2011.04.006
更新日期:2011-10-01 00:00:00
abstract::We monitored DLI treatment of 13 post-SCT relapses using quantitative competitive (QC) RT-PCR for BCR-ABL (sensitivity 10(-5)) and compared responses to DLI alone and DLI in combination with interferon-alpha (IFN). Ten relapses (one blast crisis, five cytogenetic and four molecular) were treated with DLI+IFN, three re...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(02)00280-1
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Chylomicrons carry in the bloodstream dietary fats absorbed the intestine for storage in the body tissues such as adipose and muscle. The two-step chylomicron metabolism consists in lipolysis by lipoprotein lipase on vessel walls and hepatic uptake of triglyceride-depleted remnants. Chylomicron metabolism is...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(02)00087-5
更新日期:2003-02-01 00:00:00
abstract::In 2008 the first evidence-based Canadian consensus guideline addressing the diagnosis, monitoring and management of transfusional iron overload in patients with myelodysplastic syndromes (MDS) was published. The Canadian Consortium on MDS, comprised of hematologists from across Canada with a clinical and academic int...
journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/j.leukres.2018.09.005
更新日期:2018-11-01 00:00:00
abstract::Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Although several clinical characteristics can be associated with worse prognosis, more robust biological markers still remains uncovered. SMYD2, a member of SMYD protein family, regulates the activity of several proteins through methylation. I...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2014.01.013
更新日期:2014-04-01 00:00:00
abstract::Vinorelbine chemotherapy with G-CSF stimulation is the standard mobilization regimen in Switzerland for multiple myeloma patients. However, with the increasing use of bortezomib during induction treatment, adding the neurotoxic compound vinorelbine for mobilization may aggravate bortezomib-induced polyneuropathy. In t...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2015.03.015
更新日期:2015-07-01 00:00:00
abstract::We have earlier shown that VP-16 combined with Cyclosporin A (CsA) produces tumor specific immunity to L1210 leukemia in BDF/1 mice [Slater LM, Sweet P, Stupecky M, Reynolds JT. Cyclosporin A/VP-16 produced immunity to L1210 leukemia: the participation of cytotoxic CD(8) T-lymphocytes, Clin Immunol Immunopathol 1995;7...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00105-9
更新日期:2002-02-01 00:00:00
abstract::Hemopoietic responses were studied in splenectomized mice after transplantation of the hemopoietic colony stimulating activity producing leukemia, L8313. In non-splenectomized mice, the number of peripheral leukocytes was elevated to 4 x 10(5)/mm3 after transplantation. In contrast, it was below 1.7 x 10(4)/mm3 in spl...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(89)90159-8
更新日期:1989-01-01 00:00:00
abstract::A combination of monosomy 7 and translocation t(9;22) (q34;q11), rarely observed in acute lymphoblastic leukaemia (ALL), is here reported: a peculiarity of this case was that the "breakpoint cluster region" on chromosome 22 was not rearranged, as demonstrated by molecular analysis, and a new c-abl protein (p190) was f...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90114-7
更新日期:1987-01-01 00:00:00
abstract::Endonucleases capable of producing internucleosomal DNA cleavage are one of the key enzymes in apoptosis. We examined endonuclease activities contained in nuclei of CD34+ and erythroid cells in the bone marrow (BM) from 12 patients with the myelodysplastic syndromes. The levels of Mg(2+)-dependent and acidic endonucle...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(97)00041-6
更新日期:1997-08-01 00:00:00
abstract::To evaluate the clinical usefulness of interleukin 2 (IL-2) on myelodysplastic syndromes (MDS), the serum IL-2 level, the effect of IL-2 on the proliferation of blasts, and the cell-mediated cytotoxic effect of IL-2 on blasts were examined in MDS patients. Of 18 patients, 2 patients had an increased serum IL-2 level. ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(93)90058-s
更新日期:1993-02-01 00:00:00
abstract::Bone marrow cells from 109 patients (median age 60) with newly diagnosed acute myeloid leukaemia (AML) were prospectively immunophenotyped (IP) and the prognostic value of monoclonal antibody (MAB) reactivities was analysed to detect differences in complete remission rates and survival, not only between groups of MAB ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(91)90071-z
更新日期:1991-01-01 00:00:00
abstract::The functional behavior of hematopoietic stem cell (HSC) and progenitors in chronic myelomonocytic leukemia (CMML) and on disease progression is little known. We performed cell proliferation, apoptosis, hematopoietic colony forming/replating and differentiation potential studies in the purified subpopulations of Lin(-...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2008.02.011
更新日期:2008-09-01 00:00:00
abstract::Increased DNA damage and alteration of the DNA damage response (DDR) are critical features of genetic instability presumably implicated in pathogenesis of myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML). We used immunofluorescence staining of γH2AX and 53BP1 for analyzing DNA double-strand breaks (DS...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.03.011
更新日期:2017-06-01 00:00:00
abstract::Primary cardiac lymphoma (PCL) is a rare and usually fatal neoplasm, which may cause syncope, arrhythmia, heart failure and pericardial effusion as presenting clinical complaints. A case of PCL in a 72-year-old man with moderate aortic stenosis is presented. The patient was investigated because of pericardial effusion...
journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/s0145-2126(01)00092-3
更新日期:2002-01-01 00:00:00
abstract::c-Myc has been implicated in a variety of hematologic malignancies including Burkitt's lymphoma. Targeting c-Myc driven growth pathways could be therapeutically useful but might require the identification of critical downstream proteins. Here we show that the serine-threonine kinase PBK/TOPK is frequently overexpresse...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2012.11.010
更新日期:2013-04-01 00:00:00
abstract::When spleen cells of mice grafted with STIL-3 C5 cells, a leukemic T-cell line producing IL-3, are cultured in vitro, a high IL-3 activity is detectable in the culture supernatant. However, when bone marrow cells of the same grafted mice are cultured under similar conditions, hardly any IL-3 activity is detectable. To...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(92)90035-6
更新日期:1992-09-01 00:00:00
abstract::The term "refractory anemia" was used in 1937 by Cornelius Parker Rhoads to describe patients whose anemia did not improve after treatment with liver extract or iron salts, and this term has been used to denote patients with certain subtypes of myelodysplastic syndromes (MDS) since the 1976 and 1982 French-American-Br...
journal_title:Leukemia research
pub_type: 历史文章,杂志文章
doi:10.1016/j.leukres.2016.10.007
更新日期:2016-12-01 00:00:00
abstract::A wide range of different agents are capable of inducing the onset of HL-60 differentiation along the myeloid lineage. The diversity of these agents has made the analysis of the molecular mechanisms involved in the regulation of the onset and progress of terminal differentiation in these cells difficult. We have adapt...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(89)90081-7
更新日期:1989-01-01 00:00:00
abstract::The human cell line U-937 has many features suggestive of the monocyte. It may be stimulated in vitro to develop attributes of an activated macrophage with increased phagocytosis and enhanced Fc receptor expression. We describe the establishment of a subclone designated U-937 AG through the use of a mutagenic agent. T...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(84)90084-5
更新日期:1984-01-01 00:00:00
abstract::We reported the different clinical features between Japanese and German refractory anemia (RA) patients in FAB classification. We re-analyzed the clinical features by WHO classification revised in 2008. The frequencies of refractory cytopenia with unilineage dysplasia (RCUD) and myelodysplastic syndrome-unclassified (...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.11.015
更新日期:2010-08-01 00:00:00
abstract::Concern has been expressed recently about apparent increases in the incidence of leukaemia amongst young people living in certain geographical areas. We analysed the incidence of childhood leukaemia in South-East Scotland (excluding North-East Fife) from 1970 to 1984. There was a significant geographical variation in ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(86)90091-3
更新日期:1986-01-01 00:00:00
abstract::Defective apoptosis is a hallmark of the progression of B chronic lymphocytic leukaemia (B-CLL). Smac-mimetics have been shown to induce apoptosis in several tumours. We describe the in vitro pro-apoptotic activity and regulation of the molecular pathway induced by new Smac-mimetics in B-CLL. The cytotoxic effect was ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.03.016
更新日期:2013-07-01 00:00:00
abstract::Effects of the HDAC inhibitor LBH-589 (panobinostat) on fludarabine lethality toward acute myeloid leukemia (AML) cells were examined in vitro and in vivo. LBH-589 pretreatment sensitized U937, HL-60, and primary leukemia cells to fludarabine while blocking NF-κB activation accompanied by XIAP down-regulation and JNK ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2011.10.020
更新日期:2012-04-01 00:00:00
abstract::Aplastic anemia, myelodysplastic syndromes (MDS) and chronic myeloproliferative diseases (MPD) are stem cell disorders. There is no clear-cut demarcation of them. Hypoplastic MDS displays features of aplastic anemia and MDS, on the other side mixed myelodysplastic and myeloproliferative syndromes (MDS-MPS) develop. In...
journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
doi:10.1016/0145-2126(96)00028-8
更新日期:1996-09-01 00:00:00
abstract::The tumor microenvironment (TME) is critical to the longevity of tumor B cells in chronic lymphocytic leukemia (CLL). Bone marrow mesenchymal stem cells (BMMSCs) and the cytokines they produce including IL-6 are important components of the TME in CLL. We found BMMSCs supported the survival of CLL cells in vitro throug...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2018.01.006
更新日期:2018-03-01 00:00:00
abstract::We investigated the transcript levels of genes STAT1, STAT3, STAT5A and STAT5B in the diagnostic samples of childhood ALL patients and compared them to those of healthy controls in order to characterize STAT gene expression in childhood ALL. As compared to controls, ALL patients exhibit markedly decreased transcript l...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2015.09.004
更新日期:2015-09-11 00:00:00
abstract::CD13/aminopeptidase-N, an enzyme expressed by myeloid cells, may be important in the regulation and signalling pathways that control myeloid growth and differentiation. In this study we have used the myeloid leukaemic cell line HL60, and its ability to differentiate when induced by all-trans-retinoic acid (ATRA), to s...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(94)90045-0
更新日期:1994-08-01 00:00:00