Abstract:
:In 2008 the first evidence-based Canadian consensus guideline addressing the diagnosis, monitoring and management of transfusional iron overload in patients with myelodysplastic syndromes (MDS) was published. The Canadian Consortium on MDS, comprised of hematologists from across Canada with a clinical and academic interest in MDS, reconvened to update these guidelines. A literature search was updated in 2017; topics reviewed include mechanisms of iron overload induced cellular damage, evidence for clinical endpoints impacted by iron overload including organ dysfunction, infections, marrow failure, overall survival, acute myeloid leukemia progression, and endpoints around hematopoietic stem-cell transplant. Evidence for an impact of iron reduction on the same endpoints is discussed, guidelines are updated, and areas identified where evidence is suboptimal. The guidelines address common questions around the diagnosis, workup and management of iron overload in clinical practice, and take the approach of who, when, why and how to treat iron overload in MDS. Practical recommendations for treatment and monitoring are made. Evidence levels and grading of recommendations are provided for all clinical endpoints examined.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Leitch HA,Buckstein R,Zhu N,Nevill TJ,Yee KWL,Leber B,Keating MM,St Hilaire E,Kumar R,Delage R,Geddes M,Storring JM,Shamy A,Elemary M,Wells RAdoi
10.1016/j.leukres.2018.09.005subject
Has Abstractpub_date
2018-11-01 00:00:00pages
21-41eissn
0145-2126issn
1873-5835pii
S0145-2126(18)30211-Xjournal_volume
74pub_type
杂志文章,评审abstract::Philadelphia-positive chronic myeloid leukemia (Ph+ CML) patients who are resistant to imatinib are commonly treated with second-generation tyrosine kinase inhibitors (TKIs). Limited data exist on the possible effects of these drugs on subsequent allogeneic hematopoietic stem cell transplantation (allo-HSCT).The outco...
journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.leukres.2009.04.036
更新日期:2010-02-01 00:00:00
abstract::We studied differentiation inducing effects of retinoic acid (RA), 1 alpha, 25-dihydroxyvitamin D3 (D3) and interferons (IFNs), alone and in combination, on fresh myeloid leukemic cells from 8 patients. RA not only induced the differentiation of leukemic cells in 5/8 cases, but potentiated differentiation by IFNs eith...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(90)90072-h
更新日期:1990-01-01 00:00:00
abstract::It has been suggested that acidic isoferritins play a major role in the regulation of human granulocyte-macrophage (CFU-GM) proliferation. Such regulatory isoferritins are said to occur in some human tissues including both leukaemic and normal leucocytes, and certain established cell lines. They are glycosylated and b...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(84)90065-1
更新日期:1984-01-01 00:00:00
abstract::We compared the growth-inhibitory effects and inhibition profile of the SRC family kinases (SFKs) of imatinib, dasatinib, nilotinib and INNO-406. Dasatinib exhibited the strongest potency against BCR-ABL with little selectivity over SFKs. Nilotinib exhibited a weaker affinity than the other inhibitors, but was highly ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.11.008
更新日期:2008-06-01 00:00:00
abstract::The presence of intracellular cytoplasmic immunoglobulin M (IgM) in leukemic cells from patients with acute lymphocytic leukemia (ALL) and chronic lymphocytic leukemia (CLL) was investigated by flow cytometry. The objective of the study was to develop a reproducible flow cytometric method. A Burkitt's lymphoma-derived...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(85)90126-2
更新日期:1985-01-01 00:00:00
abstract::In acute lymphoblastic leukemia (ALL) patients, automated fluorescence fragment analysis (ALF) has been reported to improve the monoclonality detection rate of immunoglobulin heavy chain genes (IgH) polymerase chain reaction (PCR) analysis. This study performed complementary determining region (CDR) I and III PCR on s...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00025-x
更新日期:2001-09-01 00:00:00
abstract::The association of monoclonal gammopathy (MG) with B-cell non-Hodgkin's lymphomas (NHL) is a well known phenomenon. The aim of the present work was to study the incidence, type of monoclonal component and prognostic significance of MG in a population of 255 cases with B-cell NHL. Among 255 evaluable patients with B-ce...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(02)00277-1
更新日期:2003-06-01 00:00:00
abstract::Inosine 5'-monophosphate (IMP) dehydrogenase catalyzes the rate-limiting reaction of guanine nucleotide biosynthesis and has been implicated in the reaction of cell growth and differentiation. We investigated the ability of mycophenolate mofetil, a prodrug of mycophenolic acid, to induce differentiation in HL-60 and U...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(00)00045-x
更新日期:2000-09-01 00:00:00
abstract::We evaluated the molecular mechanism of telomerase activation by erythropoietin (EPO) in human erythroleukemic JAS-REN-A cells. Telomerase activity increased 3-4 fold after 3-24h of culture with EPO and was associated with increases in c-myc mRNA after 1-3h, of c-Myc protein after 3-6h, and of human telomerase reverse...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2010.11.002
更新日期:2011-03-01 00:00:00
abstract::To evaluate the clinical usefulness of interleukin 2 (IL-2) on myelodysplastic syndromes (MDS), the serum IL-2 level, the effect of IL-2 on the proliferation of blasts, and the cell-mediated cytotoxic effect of IL-2 on blasts were examined in MDS patients. Of 18 patients, 2 patients had an increased serum IL-2 level. ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(93)90058-s
更新日期:1993-02-01 00:00:00
abstract::Osteogenic growth peptide (OGP) is a peptide exerting regulatory effects on the bone and on bone marrow. The carboxy-terminal pentapeptide (OGP10-14) is the biologically active portion of OGP. We evaluated OGP10-14 hematopoietic activity performing colony-forming tests on human stem cells derived by bone marrow, perip...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(02)00008-5
更新日期:2002-09-01 00:00:00
abstract::Effects of the HDAC inhibitor LBH-589 (panobinostat) on fludarabine lethality toward acute myeloid leukemia (AML) cells were examined in vitro and in vivo. LBH-589 pretreatment sensitized U937, HL-60, and primary leukemia cells to fludarabine while blocking NF-κB activation accompanied by XIAP down-regulation and JNK ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2011.10.020
更新日期:2012-04-01 00:00:00
abstract::C3H/He mice produce myeloid leukemias after whole body irradiation of 1-3Gy as compared with non-irradiated controls that produce fewer than 1% of leukemia [Radiatiton Research 127 (1991) 146]. Thus, p53-deficient C57BL/6 strain, a malignant lymphoma prone, was crossed back into C3H/He strain. Lethally irradiated wild...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(02)00032-2
更新日期:2002-12-01 00:00:00
abstract::We have recently established the MV4-11 acute myelogenous leukemia (AML) subline, designated as MV4-11 TP53 R248W, which possesses a missense mutation (CGG→TGG; R248W) in the TP53 gene, leading to inactivation of this transcription factor. DNA methyltransferase (DNMT) inhibitor 5-Aza-2'-deoxycytidine (5-AzadC) induced...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2011.04.004
更新日期:2011-07-01 00:00:00
abstract::When spleen cells of mice grafted with STIL-3 C5 cells, a leukemic T-cell line producing IL-3, are cultured in vitro, a high IL-3 activity is detectable in the culture supernatant. However, when bone marrow cells of the same grafted mice are cultured under similar conditions, hardly any IL-3 activity is detectable. To...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(92)90035-6
更新日期:1992-09-01 00:00:00
abstract::The acid phosphatase (AP), beta-glucuronidase (BG), and alpha-naphthyl-acetate esterase (ANAE) distribution and the morphology of stage 0 B-CLL lymphocytes were studied. The results were compared with the same hydrolase equipment and morphology of normal B-cell populations showing the B-CLL-like phenotype, and thus re...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90074-9
更新日期:1987-01-01 00:00:00
abstract::To highlight dasatinib role in the elderly, 125 unselected patients with CP-CML aged >60 years resistant/intolerant to imatinib were retrospectively evaluated. Grade 3-4 haematological and extra-haematological toxicities were reported in 39 (31.2%) and 34 (27.2%) patients; grade 3-4 haematological toxicity was higher ...
journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.leukres.2011.05.015
更新日期:2011-09-01 00:00:00
abstract::Cell-mediated natural cytotoxicity (CMNC) of fresh or long-term cultured lymphocytes collected from HTLV-positive patients or infected in vitro with the virus, was tested against K562 target cells. Severe depression of reactivity was found in fresh lymphocytes of three patients with advanced disease, in 12 in vitro es...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(85)90056-6
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Better risk-stratification of patients with chronic lymphocytic leukemia (CLL) and identification of subsets of ultra-high-risk (HR)-CLL patients are crucial in the contemporary era of an expanded therapeutic armamentarium for CLL. METHODS:A multivariate patient similarity network and clustering was applied...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2019.02.005
更新日期:2019-04-01 00:00:00
abstract::Bone marrow culture techniques and equilibrium density centrifugation of human bone marrow cells were used to analyse the neutrophil-granulocyte, macrophage and eosinophil-granulocyte progenitor hierarchy. The buoyant density of progenitor cells changes as cells differentiate down the granulocyte-macrophage pathway an...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(82)90061-3
更新日期:1982-01-01 00:00:00
abstract::The oral bacterium, Aggregatibacter actinomycetemcomitans, produces a leukotoxin (LtxA) that is specific for white blood cells (WBCs) from humans and Old World primates by interacting with lymphocyte function antigen-1 (LFA-1) on susceptible cells. To determine if LtxA could be used as a therapeutic agent for the trea...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.08.022
更新日期:2010-06-01 00:00:00
abstract::The Bcl-2 protein inhibits apoptosis (programmed cell death) of hematopoietic stem cells induced by a variety of noxious stimuli, thus mediating chemoresistance and decreasing chemosensitivity. Higher Bcl-2 expression correlates to an adverse outcome following therapy for acute myeloid leukemia (AML). The current stud...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.05.009
更新日期:2010-02-01 00:00:00
abstract::Malignant plasma cells exert osteoclast-like activity in vitro. We investigated the function of the calcitonin (CT) receptor (R) on myeloma cells from patients and in myeloma cell lines. Primary myeloma cells expressed high CTR levels whereas the cell lines uniformly exposed the CTR-2 variant expressed by osteoclasts....
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.07.009
更新日期:2008-04-01 00:00:00
abstract::Treatment failure of patients with acute myelogenous leukemia (AML) is frequently due to the development of multidrug resistance phenotype blasts. We have expressed a fusion protein consisting of human granulocyte-macrophage colony stimulating factor (GMCSF) fused to the N-terminus of a lectin-deficient ricin toxin B ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(97)00043-x
更新日期:1997-07-01 00:00:00
abstract::Essential thrombocythemia (ET) is an uncommon chronic myeloproliferative disorder with no cure. Patients with ET are at risk of different complications, and currently there are no optimal prognostic standards to predict severe post-diagnosis complications such as thrombosis and hemorrhage. In this study, we retrospect...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2018.03.013
更新日期:2018-06-01 00:00:00
abstract::The onset of acute myeloid leukemia following ionizing radiation or alkylating agent exposure is antedated months to years by the development of 'preleukemia', or secondary myelodysplastic syndrome (sMDS). Mitochondrial abnormalities induced by chloramphenicol and clonal deletions of mitochondrial DNA (mt DNA) in the ...
journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/0145-2126(93)90036-k
更新日期:1993-11-01 00:00:00
abstract::Chemotherapy resistance has been considered as a major problem for multiple myeloma (MM) treatment and bone marrow microenvironment plays a crucial role in the MM progression and chemoresistance. Recent studies reported that bone marrow mesenchymal stem cells derived from MM patients (MM-MSCs) revealed various charact...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.07.002
更新日期:2017-09-01 00:00:00
abstract::This study was aimed to illustrate the significance of minimal residual disease (MRD) assessment on day 22 in childhood acute lymphoblastic leukemia. MRD were measured on day 22, day 36, week 12, month 6 and month 12 by four-color flow cytometry. The 5-year cumulative incidence of relapse was significantly different f...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.leukres.2012.03.014
更新日期:2012-08-01 00:00:00
abstract::This study examined the immunoregulatory role of recombinant interleukin 4 (IL-4), also known as B-cell stimulating factor 1, on the generation of cytotoxic effector cells from normal and leukaemic human blood mononuclear cells. When tested on cells from normal individuals, the addition of IL-4 to mixed lymphocyte cul...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(89)90066-0
更新日期:1989-01-01 00:00:00
abstract::To determine the role of cell-mediated immunity (CMI) to cytomegalovirus (CMV) in leukemic children after CMV infection, CMI to CMV antigen was studied using CMV-specific lymphocyte blastogenic responses (LBR) and interferon (IFN) production. Four children, who continuously secreted CMV in urine more than 2 years afte...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(94)90086-8
更新日期:1994-07-01 00:00:00