Iron overload in myelodysplastic syndromes: Evidence based guidelines from the Canadian consortium on MDS.


:In 2008 the first evidence-based Canadian consensus guideline addressing the diagnosis, monitoring and management of transfusional iron overload in patients with myelodysplastic syndromes (MDS) was published. The Canadian Consortium on MDS, comprised of hematologists from across Canada with a clinical and academic interest in MDS, reconvened to update these guidelines. A literature search was updated in 2017; topics reviewed include mechanisms of iron overload induced cellular damage, evidence for clinical endpoints impacted by iron overload including organ dysfunction, infections, marrow failure, overall survival, acute myeloid leukemia progression, and endpoints around hematopoietic stem-cell transplant. Evidence for an impact of iron reduction on the same endpoints is discussed, guidelines are updated, and areas identified where evidence is suboptimal. The guidelines address common questions around the diagnosis, workup and management of iron overload in clinical practice, and take the approach of who, when, why and how to treat iron overload in MDS. Practical recommendations for treatment and monitoring are made. Evidence levels and grading of recommendations are provided for all clinical endpoints examined.


Leuk Res


Leukemia research


Leitch HA,Buckstein R,Zhu N,Nevill TJ,Yee KWL,Leber B,Keating MM,St Hilaire E,Kumar R,Delage R,Geddes M,Storring JM,Shamy A,Elemary M,Wells RA




Has Abstract


2018-11-01 00:00:00












  • Myelodysplastic syndrome in childhood: report of two cases with deletion of chromosome 4 and the Philadelphia chromosome.

    abstract::We report two pediatric patients with unclassified myelodysplastic syndrome (MDS) by the French-American-British (FAB) group. Both cases had clinical and hematological peculiarities, which had not been described yet. The cytogenetic alterations were 4q deletion and the Philadelphia (Ph) chromosome which appeared at di...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Dalla Torre CA,de Martino Lee ML,Yoshimoto M,Lopes LF,Melo LN,Caminada de Toledo SR,Duffles Andrade JA

    更新日期:2002-06-01 00:00:00

  • Chronic myelogenous leukemia cells convert to myofibroblasts in vitro: effect of vascular endothelial growth factor on development of the microenvironment.

    abstract::To elucidate the biological characteristics of chronic myelogenous leukemia (CML) cells, we observed morphological and functional changes of CML cells during primary long-term culture, in which their morphology changed to that of myofibroblasts with similar molecular characteristics to the parental CML cells including...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Shirasaki R,Tashiro H,Mizutani-Noguchi M,Kawasugi K,Shirafuji N

    更新日期:2011-05-01 00:00:00

  • DNA and RNA analysis by flow cytometry of the leukemia in AKR mice.

    abstract::The development of the leukemia-lymphoma complex was studied in AKR/J (H-2k) mice using flow cytometry and staining with acridine orange. Investigation of cytokinetics and of cellular RNA content showed that during the neonatal period all mice had a significant increase of S phase cells in the thymus, bone marrow, lym...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Wustrow TP,Andreeff M,Fernandes G,Good RA

    更新日期:1985-01-01 00:00:00

  • Epigenetic drug combination overcomes osteoblast-induced chemoprotection in pediatric acute lymphoid leukemia.

    abstract::Although there has been much progress in the treatment of acute lymphoblastic leukemia (ALL), decreased sensitivity to chemotherapy remains a significant issue. Recent studies have shown how interactions with the bone marrow microenvironment can protect ALL cells from chemotherapy and allow for the persistence of the ...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Quagliano A,Gopalakrishnapillai A,Barwe SP

    更新日期:2017-05-01 00:00:00

  • All-trans and 9-cis retinoic acid enhance 1,25-dihydroxyvitamin D3-induced monocytic differentiation of U937 cells.

    abstract::Retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (D3) are well known for inducing differentiation in many leukemic cell lines. The nuclear signalling pathways of RA and D3 are mediated through their cognate receptors, the retinoic acid receptor (RAR) and vitamin D3 receptor (VDR), respectively. Retinoid X receptor (RXR...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Nakajima H,Kizaki M,Ueno H,Muto A,Takayama N,Matsushita H,Sonoda A,Ikeda Y

    更新日期:1996-08-01 00:00:00

  • Telomere length, c-myc and mad-1 expression could represent prognosis markers of myelodysplastic syndrome.

    abstract::Telomere dysfunction might generate genomic instability leading to the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). We investigated telomere length (TL), telomerase activity (TA) and hTERT, c-myc, mad1, and p53 expression in the bone marrow of patients with MDS (n=109), AML (n=47) ...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Poloni A,Serrani F,Berardinelli E,Maurizi G,Mariani M,Costantini B,Trappolini S,Mancini S,Olivieri A,Leoni P

    更新日期:2013-11-01 00:00:00

  • Role of microRNA deregulation in the pathogenesis of diffuse large B-cell lymphoma (DLBCL).

    abstract::MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate gene expression at the post-transcriptional level through its sequence complementation with target mRNAs. An individual miRNA species can simultaneously influence the expression of multiple genes and conversely, several miRNAs can synchronously contro...

    journal_title:Leukemia research

    pub_type: 杂志文章,评审


    authors: Mazan-Mamczarz K,Gartenhaus RB

    更新日期:2013-11-01 00:00:00

  • Acute myeloid leukemia with 11q23 rearrangements: A study of therapy-related disease and therapeutic outcomes.

    abstract::We described the clinical features and outcomes for 63 adult patients with acute myeloid leukemia (AML) with a translocation involving the 11q23 locus (MLL) who were treated at Memorial Sloan Kettering Cancer Center (MSK). The population included 40 female (63 %) and 23 male (37 %) patients, with a median age of 51 ye...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Menghrajani K,Zhang Y,Famulare C,Devlin SM,Tallman MS

    更新日期:2020-11-01 00:00:00

  • Human B-cell lymphoma cell lines are highly sensitive to apoptosis induced by all-trans retinoic acid and interferon-gamma.

    abstract::When cells were incubated in the presence of both interferon-gamma (IFN-gamma) and all-trans retinoic acid (ATRA), the concentration of IFN-gamma required to induce apoptosis of B-cell lymphoma cells was much lower than that required for myeloid or erythroid cell lines. The concentration of IFN-gamma that effectively ...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Niitsu N,Higashihara M,Honma Y

    更新日期:2002-08-01 00:00:00

  • Ph-negative acute lymphocytic leukemia occurring after interferon therapy for Ph-positive chronic myelocytic leukemia.

    abstract::We report a unique case of chronic myelocytic leukemia (CML) with the Philadelphia (Ph) chromosome. The patient obtained cytogenetic complete remission (CR) after treatment with interferon (IFN). When he transformed to acute lymphocytic leukemia (ALL), cytogenetic analysis showed that the karyotype was normal and fluo...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Zhang X,Ji L,Liu S,Wang J

    更新日期:2003-04-01 00:00:00

  • Semenogelin I expression in myeloma cells can be upregulated pharmacologically.

    abstract::Semenogelin (SEMG) I is a Cancer-Testis (CT) antigen that we have found to be expressed in myeloma cells. In this study, we set out to determine whether the expression of SEMG I could be upregulated pharmacologically. We found that SEMG I expression in myeloma cells can be upregulated by 5-azacytidine, IL-4 and IL-6. ...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Zhang Y,Wang Z,Zhang J,Farmer B,Lim SH

    更新日期:2008-12-01 00:00:00

  • A leukemic plasmacytoid dendritic cell line, PMDC05, with the ability to secrete IFN-alpha by stimulation via Toll-like receptors and present antigens to naïve T cells.

    abstract::We established a plasmacytoid dendritic cell (pDC) line (PMDC05) from leukemia cells of pDC leukemia. PMDC05 cells were positive for CD4, CD56, CD33, HLA-DR, CD123 (IL-3Ralpha) and CD86 in the absence of lineage markers. mRNA of TLR1, TLR2, TLR4, TLR7 and TLR9 was clearly expressed and among these TLRs, TLR7 was promi...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Narita M,Watanabe N,Yamahira A,Hashimoto S,Tochiki N,Saitoh A,Kaji M,Nakamura T,Furukawa T,Toba K,Fuse I,Aizawa Y,Takahashi M

    更新日期:2009-09-01 00:00:00

  • Reduced-intensity conditioning therapy with fludarabine, idarubicin, busulfan and cytarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.

    abstract::We retrospectively analyzed allogenic stem cell transplantation (allo-SCT) outcomes in 82 patients with AML or MDS were conditioned with fludarabine, idarubicin, intravenous-busulfan and cytarabine (FIBA) or busulfan and cyclophosphamide (BuCy). Compared to BuCy regimen, reduced intensity conditioning (RIC) with FIBA ...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Gao L,Gao L,Gong Y,Zhang C,Chen XH,Zhang X

    更新日期:2013-11-01 00:00:00

  • Synergism between clofarabine and decitabine through p53R2: a pharmacodynamic drug-drug interaction modeling.

    abstract::Clofarabine (CLO), a purine nucleoside analog with promising efficacy in acute myeloid leukemia (AML), inhibits the ribonucleotidereductase, p53R2. We have shown that p53R2 mRNA is up-regulated by decitabine (DEC), another drug with promising activity in AML. We developed a pharmacodynamic model to characterize the in...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Thudium KE,Ghoshal S,Fetterly GJ,Haese JP,Karpf AR,Wetzler M

    更新日期:2012-11-01 00:00:00

  • Monosomy 7 and Ph-positive acute lymphoblastic leukaemia: cytogenetic and molecular aspects.

    abstract::A combination of monosomy 7 and translocation t(9;22) (q34;q11), rarely observed in acute lymphoblastic leukaemia (ALL), is here reported: a peculiarity of this case was that the "breakpoint cluster region" on chromosome 22 was not rearranged, as demonstrated by molecular analysis, and a new c-abl protein (p190) was f...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Eridani S,Gorman P,Sheer D,Duncombe AS,Glass UH,Shivji MK

    更新日期:1987-01-01 00:00:00

  • Preclinical and clinical results with pomalidomide in the treatment of relapsed/refractory multiple myeloma.

    abstract::Despite the evolution of effective frontline treatment strategies, many patients with myeloma inevitably relapse. Treatment can be complicated by the interplay of disease-, treatment-, and patient-related factors. Unfortunately, many patients eventually develop disease that is refractory to lenalidomide and bortezomib...

    journal_title:Leukemia research

    pub_type: 杂志文章,评审


    authors: Mark TM,Coleman M,Niesvizky R

    更新日期:2014-05-01 00:00:00

  • Clonality analysis of childhood ALL in remission: no evidence of clonal hematopoiesis.

    abstract::We studied 98 female patients in remission (2-240 months) from childhood ALL to determine the clonality status of their hematopoiesis. Thirty-one (31.6%) were heterozygous at the PGK locus for the BstX1 endonuclease restriction site, permitting X-linked clonality assays to be performed. Two patients were in relapse at...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Busque L,Ilaria R Jr,Tantravahi R,Weinstein H,Gilliland DG

    更新日期:1994-02-01 00:00:00

  • Magnetic resonance imaging for monitoring relapse of acute myeloid leukemia.

    abstract::Magnetic resonance provides a non-invasive tool for monitoring normal and leukemic bone marrow. Measurements of the T1 relaxation times are elevated in acute myelogenous leukemia. However, interpatient variability diminishes the usefulness of MR measurements for diagnosing leukemia. In following the time course of ind...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Henkelman RM,Messner H,Poon PY,Hinks RS,Stewart C,Curtis J,Minden M,Baker M

    更新日期:1988-01-01 00:00:00

  • Single-dose mitoxantrone in combination with continuous infusion intermediate-dose cytarabine plus etoposide for treatment of refractory or early relapsed acute myeloid leukemia.

    abstract::This prospective phase II clinical trial evaluated the effects of single-dose mitoxantrone (36 mg/m2 on day 1) in combination with continuous infusion intermediate-dose cytarabine plus etoposide in 25 patients with refractory or early relapsed acute myeloid leukemia (AML). We compared the results of our current study ...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Lee SS,Lee JH,Lee JH,Kim DY,Kim SH,Lim SN,Lee YS,Seol M,Ryu SG,Kang YA,Jang S,Park CJ,Chi HS,Yun SC,Lee KH

    更新日期:2009-04-01 00:00:00

  • Constitutional trisomy 8 and myelodysplasia: report of a case and review of the literature.

    abstract::A diagnosis of myelodysplastic syndrome was made in an 18-year-old patient with Warkany syndrome due to constitutional trisomy 8 mosaicism. The possible causal role of this particular chromosome constitution with respect to myelodysplasia and embryonal childhood tumors is discussed. ...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Zollino M,Genuardi M,Bajer J,Tornesello A,Mastrangelo S,Zampino G,Mastrangelo R,Neri G

    更新日期:1995-10-01 00:00:00

  • Screening for induction of differentiation and toxicity to blast cells by chemotherapeutic compounds in human myeloid leukemia.

    abstract::Bone marrow cells from 9 patients with acute myeloid leukemia and 1 patient with a blast crisis of chronic myeloid leukemia were cultured to determine their ability to be induced to differentiate by different chemotherapeutic compounds. Five of these 10 patients showed differentiation to granulocytic and/or monocytic ...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Lotem J,Berrebi A,Sachs L

    更新日期:1985-01-01 00:00:00

  • Treatment of unfavorable myelodysplastic syndrome with all-trans-retinoic acid and subcutaneous Ara C.

    abstract::Thirty patients with high-risk myelodysplastic syndrome, defined as > 5% bone marrow blasts, were treated with a combination of oral all-trans-retinoic acid (45 mg/m2 daily) and subcutaneous AraC (10 mg/m2) on days 1-14 of each 28-35 day cycle repeated for 2-6 cycles. Complete remission lasting 9, 12, and 15 months wa...

    journal_title:Leukemia research

    pub_type: 临床试验,杂志文章


    authors: Letendre L,Noel P,White WL,Tefferi A,Litzow MR,Li CY,Schroeder G

    更新日期:1999-09-01 00:00:00

  • Clinico-pathological characteristics of myeloid sarcoma at diagnosis and during follow-up: report of 12 cases from a single institution.

    abstract::The aim of this study was to describe the presenting features, the frequency and outcome of myeloid sarcoma (MS) diagnosed in our Institution from January 1995 to December 2000. Twelve MS were seen and the frequency account for only 2% of all acute myeloid leukemia (AML) patients observed in our department in the same...

    journal_title:Leukemia research

    pub_type: 杂志文章,评审


    authors: Breccia M,Mandelli F,Petti MC,D'Andrea M,Pescarmona E,Pileri SA,Carmosino I,Russo E,De Fabritiis P,Alimena G

    更新日期:2004-11-01 00:00:00

  • Indomethacin induces apoptosis and inhibits proliferation in chronic myeloid leukemia cells.

    abstract::A nonsteroidal anti-inflammatory drug (NSAID)--indomethacin (IN), was found to induce apoptosis and inhibit proliferation of K562 cells and primary culture bone marrow cells from six chronic myelogenous leukemia (CML) patients. IN induced cells apoptosis and inhibited cells proliferation in a dose-and time-dependent m...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Zhang G,Tu C,Zhang G,Zhou G,Zheng W

    更新日期:2000-05-01 00:00:00

  • Characterization of the AKR thymic microenvironment and its influence on thymocyte differentiation and lymphoma development.

    abstract::The thymic stroma has long been implicated in AKR thymic leukaemia. In this study an extensive panel of monoclonal antibodies was used to investigate changes in the AKR thymic microenvironment, in parallel with thymocyte differentiation of normal (2 month), preleukaemic (5-7 month) and leukaemic (> 7 month) mice. We f...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Davey GM,Tucek-Szabo CL,Boyd RL

    更新日期:1996-10-01 00:00:00

  • Prognostic importance of Aurora Kinases and mitotic spindle genes transcript levels in Myelodysplastic syndrome.

    abstract::Myelodysplastic syndrome (MDS) are a heterogeneous group of clonal disease characterized by insufficiency of bone marrow, increase of apoptosis and increased risk of acute leukemia progression. Proteins related to the mitotic spindle (AURKA, AURKB, TPX2), to the mitotic checkpoint (MAD2, CDC20) and the regulation of t...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Borges DP,Dos Santos AWA,Paier CRK,Ribeiro HL Júnior,Costa MB,Farias IR,de Oliveira RTG,França IGDF,Cavalcante GM,Magalhães SMM,Pinheiro RF

    更新日期:2018-01-01 00:00:00

  • Minimal residual disease in vitro of a pre-B-lymphoma.

    abstract::We have studied the survival of clonogenic neoplastic cells of a murine pre-B-lymphoma (BCl-1) of the spleen in culture. We have found quantitative deficiencies such as reduced surface adherence of stromal cells and impaired CFU-F (colony forming units-fibroblast) and pre-CFU-F colony and layer formation in stromal cu...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Prindull G,Ben-Ishay Z,Bergholz M,Prindull B

    更新日期:1993-07-01 00:00:00

  • Deficiency of UV-induced excision repair in human thymocytes.

    abstract::The capacity of human thymocytes and of differentiated lymphocytes circulating in peripheral blood to perform unscheduled DNA synthesis (a measure of nucleotide excision repair) after UV irradiation was measured by radioautographic analysis. Only 4% of immature T lymphocytes, but 68% of circulating lymphocytes exhibit...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Gensler HL,Lindberg RE,Pinnas JL,Jones JF

    更新日期:1985-01-01 00:00:00

  • The automated monocyte count is independently predictive of overall survival from diagnosis in chronic lymphocytic leukaemia and of survival following first-line chemotherapy.

    abstract::We conducted an analysis of the effect of monocytosis at diagnosis of CLL on subsequent overall (OS) and treatment-free survival (TFS). Monocyte counts were performed using the Sysmex XE2100 analyser. A monocyte count >0.9 × 10(9)L(-1) at the time of diagnosis was associated with a shortened OS and TFS. Monocytosis at...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Mazumdar R,Evans P,Culpin R,Bailey J,Allsup D

    更新日期:2013-06-01 00:00:00

  • Pycnogenol induces differentiation and apoptosis in human promyeloid leukemia HL-60 cells.

    abstract::Pycnogenol, rich of many phytochemicals of medical value, is a commercialized nutrient supplement extracted from the bark of European coastal pine. In this study, we investigated the anti-tumor effects of Pycnogenol on HL-60, U937 and K562 human leukemia cell lines. We found that Pycnogenol inhibited cell proliferatio...

    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Huang WW,Yang JS,Lin CF,Ho WJ,Lee MR

    更新日期:2005-06-01 00:00:00