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Ca2+/Mg(2+)-dependent endonuclease in marrow CD34 positive and erythroid cells in myelodysplasia.

Abstract：

:Endonucleases capable of producing internucleosomal DNA cleavage are one of the key enzymes in apoptosis. We examined endonuclease activities contained in nuclei of CD34+ and erythroid cells in the bone marrow (BM) from 12 patients with the myelodysplastic syndromes. The levels of Mg(2+)-dependent and acidic endonucleases showed little changes as compared with those from normal BM. By contrast, the level of Ca2+/Mg(2+)-dependent endonuclease was appreciably higher in MDS erythroid cells than normal counterparts, although the activity varied markedly in CD34+ and erythroid cells. Our results suggested that Ca2+/Mg(2+)-dependent endonuclease is related to ineffective erythropoiesis in MDS.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Anzai N,Kawabata H,Hishita T,Yoshida Y,Ueda Y,Okuma M

doi

10.1016/s0145-2126(97)00041-6

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

731-4

issue

8

eissn

0145-2126

issn

1873-5835

pii

S0145212697000416

journal_volume

21

pub_type

杂志文章

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