Abstract：
:A combination of monosomy 7 and translocation t(9;22) (q34;q11), rarely observed in acute lymphoblastic leukaemia (ALL), is here reported: a peculiarity of this case was that the "breakpoint cluster region" on chromosome 22 was not rearranged, as demonstrated by molecular analysis, and a new c-abl protein (p190) was found, instead of the usual p210 protein usually associated with the Ph chromosome; moreover a rearrangement of c-abl oncogene was found. The clinical course of this patient was, as expected, unfavorable: a few normal metaphases were observed during a short partial remission.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Eridani S,Gorman P,Sheer D,Duncombe AS,Glass UH,Shivji MKdoi
10.1016/0145-2126(87)90114-7subject
Has Abstractpub_date
1987-01-01 00:00:00pages
965-9issue
11eissn
0145-2126issn
1873-5835journal_volume
11pub_type
杂志文章abstract：:Although biological and clinical features differ between B-lineage acute lymphoblastic leukemia (ALL) and T-lineage ALL (T-ALL), there have been few reports that focused on the prognosis for T-ALL in adults, primarily due to its rarity. Here, we studied the long-term outcomes and prognostic factors specific for adult ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.08.004
更新日期：2007-07-01 00:00:00
abstract：:Model cell lines are essential tools for investigating the biology and therapeutics of cancer. Approximately 1500 human hematopoietic neoplastic cell lines have been described, covering most major disease entities. Waldenström's macroglobulinemia (WM) is a rare incurable hematological neoplasm from which only three ce...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2008.04.016
更新日期：2008-11-01 00:00:00
abstract：:Leukemic bcr-abl positive dendritic cells (DCs) are likely to be present in vivo in chronic myelogenous leukemia (CML) patients, but no data are available on their functional qualities. We analyzed the circulating BDCA-1+ myeloid DC compartment in 15 chronic phase CML patients. Phenotypic features of CML DCs were comp...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.11.028
更新日期：2006-07-01 00:00:00
abstract：:Leukemic cell lines have become important tools for studies of disease providing a monoclonal cell population that can be extensively expanded in vitro while preserving leukemic cellular characteristics. However, studies of chronic lymphocytic leukemia (CLL) have been impeded in part by the lack of continuous human ce...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2015.10.008
更新日期：2016-01-01 00:00:00
abstract：:The hotspot c.7541_7542delCT NOTCH1 mutation has been proven to have a negative clinical impact in chronic lymphocytic leukemia (CLL). However, an optimal method for its detection has not yet been specified. The aim of our study was to examine the presence of the NOTCH1 mutation in CLL using three commonly used molecu...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2017.08.001
更新日期：2017-09-01 00:00:00
abstract：:The role of hemin induction of K562 in inositol phospholipid metabolism has not been previously studied. K562 cells were induced to synthesize hemoglobin upon addition of bovine hemin to the culture media. The phospholipid content of K562 was determined before and after the addition of hemin. The results of this study...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90055-x
更新日期：1991-01-01 00:00:00
abstract：:A retrospective analysis of the relationship between the initial classification according to either FAB or WHO criteria, the presence of risk factors and the type of therapy including stem cell transplantation (SCT) on the survival was performed in a group of 106 patients with primary myelodysplastic syndrome (MDS) of...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2003.10.016
更新日期：2004-06-01 00:00:00
abstract：:The basis of intrinsic resistance of blasts from patients with acute non-lymphocytic leukemia (ANLL) to methotrexate was studied. MTX polyglutamate formation was measured in blast cells from 19 patients with ANLL and in 7 pediatric patients with acute lymphocytic leukemia (ALL), after in vitro incubation for 24 h with...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90189-z
更新日期：1991-01-01 00:00:00
abstract：:Limited information is available on the relationship between expression of some additional aberrant phenotypic features and outcome of acute promyelocytic leukemia (APL) patients. Here, we set out to assess the frequency of CD15 and CD56 expression, and their prognostic value in a large series of APL patients. One hun...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2013.11.008
更新日期：2014-02-01 00:00:00
abstract：:The in-vitro effects of deoxycoformycin (dCF) on dATP, NAD, ATP and DNA strand breaks have been evaluated in the cells from 42 patients with various types of chronic lymphoid leukemia. These included 18 with B-cell chronic lymphoid leukemias of different types (BCL); 10 with hairy cell leukemia (HCL) and 14 with T-cel...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90140-8
更新日期：1987-01-01 00:00:00
abstract：:Incidence and outcomes of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) are not well established at the population level, especially since the widespread use of immunophenotyping. We studied the epidemiology of CLL in Manitoba (Canada) by combining data from a centralized flow cytometry facility and th...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.06.013
更新日期：2009-11-01 00:00:00
abstract：:This prospective phase II clinical trial evaluated the effects of single-dose mitoxantrone (36 mg/m2 on day 1) in combination with continuous infusion intermediate-dose cytarabine plus etoposide in 25 patients with refractory or early relapsed acute myeloid leukemia (AML). We compared the results of our current study ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2008.08.009
更新日期：2009-04-01 00:00:00
abstract：:1,25-Dihydroxyvitamin D3 (1,25D) induces differentiation of myeloid leukemia cells, but resistant cells are also encountered. We studied the mechanistic basis for the resistance in a model system using enhancers of 1,25D, the antioxidant carnosic acid and a kinase inhibitor SB202190. Knock-down (KD) of JNK2p54 unexpec...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.03.003
更新日期：2009-10-01 00:00:00
abstract：:Forty patients with high risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) preceded by MDS were treated with intensive induction and consolidation chemotherapy in a prospective multicenter pilot study. They were given two cycles of cytarabine 100 mg/m with 12-h intervals on days 1-7 and idarubicin 12...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/s0145-2126(96)00116-6
更新日期：1997-02-01 00:00:00
abstract：:Although mutations in RNA splicing genes occur frequently in patients with clonal cytopenias of unknown significance (CCUS) and myelodysplastic syndromes (MDS), very often additional common myeloid gene driver mutations are present at diagnosis. Thus, the clinical significance of isolated mutations in the most commonl...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2017.09.002
更新日期：2017-10-01 00:00:00
abstract：:The aim of this study was to describe the presenting features, the frequency and outcome of myeloid sarcoma (MS) diagnosed in our Institution from January 1995 to December 2000. Twelve MS were seen and the frequency account for only 2% of all acute myeloid leukemia (AML) patients observed in our department in the same...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2004.01.022
更新日期：2004-11-01 00:00:00
abstract：:Septins are proteins associated with crucial steps in cell division and cellular integrity. In humans, 14 septin genes have been identified, of which five (SEPT2, SEPT5, SEPT6, SEPT9, and SEPT11) are known to participate in reciprocal translocations with the MLL gene in myeloid neoplasias. We have recently shown a sig...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.08.018
更新日期：2010-05-01 00:00:00
abstract：:p23 is a heat shock protein 90 (Hsp90) cochaperone that plays a significant role in estrogen receptor (ER) alpha signal transduction and telomerase activity; it is up-regulated in several cancers. Recent studies have found that high level of p23 may promote tumor progression and poor prognosis in breast cancer patient...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.05.003
更新日期：2012-09-01 00:00:00
abstract：:Medullary dyserythropoiesis with reduced production of erythrocytes is an early and consistent feature of myelodysplastic syndromes (MDS). The mechanism underlying the disturbed red cell proliferation and maturation is presently unknown. In order to study the role of erythropoietic growth factors, we determined by rad...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90025-o
更新日期：1991-01-01 00:00:00
abstract：:Multiple myeloma (MM) is an incurable plasma cell malignancy, which causes a significant morbidity due to organ damage and bone tissue destruction. In recent years, novel drugs have become available for MM therapy thanks to a more deepened knowledge of this disease's pathogenesis. The perspective of employing targeted...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2012.10.016
更新日期：2013-02-01 00:00:00
abstract：:The acid phosphatase (AP), beta-glucuronidase (BG), and alpha-naphthyl-acetate esterase (ANAE) distribution and the morphology of stage 0 B-CLL lymphocytes were studied. The results were compared with the same hydrolase equipment and morphology of normal B-cell populations showing the B-CLL-like phenotype, and thus re...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90074-9
更新日期：1987-01-01 00:00:00
abstract：:Immunophenotypic classification of the acute leukemias (AcL) is of well documented value in those of lymphoid or uncertain origin and of increasing importance in those of nonlymphoid origin. Most of these studies have been performed on viable cell suspensions. To study the efficacy of a simpler immunohistochemical app...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90080-4
更新日期：1987-01-01 00:00:00
abstract：:CD13/aminopeptidase-N, an enzyme expressed by myeloid cells, may be important in the regulation and signalling pathways that control myeloid growth and differentiation. In this study we have used the myeloid leukaemic cell line HL60, and its ability to differentiate when induced by all-trans-retinoic acid (ATRA), to s...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(94)90045-0
更新日期：1994-08-01 00:00:00
abstract：:High CD23 expression is a hallmark of B-CLL cells. It is lost during in vitro culture and can be reinduced by IL-4, albeit to a lower extent than in normal B cells. To elucidate the events controlling CD23 expression in B-CLL cells, the IL-4 mediated induction of STAT6 was investigated. Western-blot analysis demonstra...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(99)00191-5
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Current results regarding treatment outcomes in acute myeloid leukemia (AML) point to significant differences between low- and middle-income countries (LMIC) and high-income countries (HIC). Excluding well-known socioeconomic issues, genetic markers important for prognosis have not been properly incorporated...
journal_title：Leukemia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.leukres.2017.07.005
更新日期：2017-09-01 00:00:00
abstract：:We have investigated the production of metalloproteinases (MMP-1, MMP-2, MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in bone marrow stromal cells (BMSCs) of patients with multiple myeloma (MM) and a healthy control. The new findings of this paper is that BMSCs of the MM patients exhibited in...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2008.04.001
更新日期：2008-11-01 00:00:00
abstract：:Fractionation of mononuclear cells from human fetal liver provides a cell population at early stages of myeloid differentiation which, when cultured, generates neutrophils and macrophages for up to a month. These studies describe the further purification of an undifferentiated myeloid blast cell population by rosette ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(90)90114-o
更新日期：1990-01-01 00:00:00
abstract：:The association between seven polymorphisms in the genes hOCT1 and MDR1, encoding for imatinib transporter proteins, and the response to imatinib 400mg/daily was investigated in 65 patients newly diagnosed with chronic-phase chronic myeloid leukemia. The AA genotype at the rs6935207 hOCT1 polymorphic locus was not det...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2010.12.004
更新日期：2011-08-01 00:00:00
abstract：:The aberrant changes of tumor suppressor genes (TSGs) are now recognized as an important mechanism contributing to the development of acute myeloid leukemia (AML). CCAAT/enhancer binding protein zeta (C/EBPζ), a candidate TSG, has been found to be involved in cancers including AML. We detected the methylation status o...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2010.10.031
更新日期：2011-07-01 00:00:00
abstract：:In a prospective study of 27 patients with acute myeloid leukaemia (AML) quality of life was studied using three different instruments, Life Ingredient Profile, Karnofsky Performance Scale and Vitagram. The course of the disease was followed during the induction period, remission, relapse and in the terminal phase. We...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(94)90028-0
更新日期：1994-04-01 00:00:00
