Abstract:
:We have investigated the production of metalloproteinases (MMP-1, MMP-2, MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in bone marrow stromal cells (BMSCs) of patients with multiple myeloma (MM) and a healthy control. The new findings of this paper is that BMSCs of the MM patients exhibited intrinsic MMP-1, MMP-2 and TIMP-2 overproduction. Production of MMP-1, TIMP-2 and activation of MMP-2 was additionally enhanced in co-cultures of BMSCs with RPMI8226 cells. The ratio between MMP-2 and TIMP-2 was significantly higher in BMSCs of the MM patients than in control. BMSCs of both the control and the MM patients exhibited the presence of MMP-9 latent form, but in co-cultures RPMI8226 cells were the main producers of this metalloproteinase.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Zdzisińska B,Walter-Croneck A,Kandefer-Szerszeń Mdoi
10.1016/j.leukres.2008.04.001subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1763-9issue
11eissn
0145-2126issn
1873-5835pii
S0145-2126(08)00182-3journal_volume
32pub_type
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journal_title:Leukemia research
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journal_title:Leukemia research
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pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.07.022
更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2004-03-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00