Abstract:
:The treatment of acute leukemia is still challenging due in part to the development of resistance and relapse. This chemotherapeutics resistance is established by clonal selection of resistant variants of the cancer cells. Recently, a horizontal transfer of chemo-resistance among cancer cells via extracellular vesicles (EVs) has been suggested. The aim of this research was to investigate the role of EVs in chemo-resistance in acute myeloid leukemia. For this purpose, the sensitive strain of the promyelocytic leukemia HL60 cell line was studied along with its multi-resistant strain, HL60/AR that overexpresses the multidrug resistance protein 1 (MRP-1). A chemo-resistance transfer between the two strains was established by treating HL60 cells with EVs generated by HL60/AR. This study reveals that EVs from HL60/AR can interact with HL60 cells and transfer at least partially, their chemo-resistance. EVs-treated cells begin to express MRP-1 probably due to a direct transfer of MRP-1 and nucleic acids transported by EVs. In this context, two microRNAs were highlighted for their high differential expression in EVs related to sensitive or chemo-resistant cells: miR-19b and miR-20a. Because circulating microRNAs are found in all biological fluids, these results bring out their potential clinical use as chemo-resistance biomarkers in acute myeloid leukemia.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Bouvy C,Wannez A,Laloy J,Chatelain C,Dogné JMdoi
10.1016/j.leukres.2017.09.014subject
Has Abstractpub_date
2017-11-01 00:00:00pages
70-76eissn
0145-2126issn
1873-5835pii
S0145-2126(17)30522-2journal_volume
62pub_type
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2011.04.006
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90109-3
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pub_type: 杂志文章
doi:10.1016/j.leukres.2017.11.005
更新日期:2018-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(88)90098-7
更新日期:1988-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.08.001
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.03.021
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pub_type: 杂志文章
doi:10.1016/j.leukres.2017.07.002
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(89)90100-8
更新日期:1989-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.11.033
更新日期:2008-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.12.021
更新日期:2010-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.leukres.2019.106225
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
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更新日期:2009-08-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(92)90128-t
更新日期:1992-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(88)90002-1
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