当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > HA14-1, a small molecule inhibitor of Bcl-2, bypasses chemoresistance in leukaemia cells.

HA14-1, a small molecule inhibitor of Bcl-2, bypasses chemoresistance in leukaemia cells.

Abstract：

:We analyzed the biological activity of HA14-1, a small organic compound inhibitor of Bcl-2, against established leukaemia cell lines and blasts from acute myeloid leukaemia (AML) patients. HA14-1 had a potent killing activity against the leukaemia cell line that expressed endogenous or ectopic Bcl-2. This activity was mostly caspase-independent and was not altered by the expression of a multidrug-resistant phenotype. Moreover, HA14-1 efficiently induced cell death in a broad spectrum of AML blasts but not in normal peripheral blood lymphocytes. Thus, single-agent regimens using Bcl-2 inhibitors such as HA14-1 may be advantageous in overcoming some forms of chemoresistance in AML.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Oliver L,Mahé B,Gréé R,Vallette FM,Juin P

doi

10.1016/j.leukres.2006.11.010

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

859-63

issue

6

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(06)00457-7

journal_volume

31

pub_type

杂志文章

相关文献

LEUKEMIA RESEARCH文献大全
  • The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus.

    abstract：:The technology of array comparative genomic hybridization (array-CGH/aCGH) enabled the identification of novel genomic aberrations in chronic lymphocytic leukemia (CLL) including the monoallelic and biallelic deletions affecting 22q11 locus. In contrast to previous publications, we hypothesized that the described 22q1...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2013.03.018

    authors： Mraz M,Stano Kozubik K,Plevova K,Musilova K,Tichy B,Borsky M,Kuglik P,Doubek M,Brychtova Y,Mayer J,Pospisilova S

    更新日期：2013-07-01 00:00:00

  • c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D.

    abstract：:1,25-Dihydroxyvitamin D3 (1,25D) induces differentiation of myeloid leukemia cells, but resistant cells are also encountered. We studied the mechanistic basis for the resistance in a model system using enhancers of 1,25D, the antioxidant carnosic acid and a kinase inhibitor SB202190. Knock-down (KD) of JNK2p54 unexpec...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2009.03.003

    authors： Chen-Deutsch X,Garay E,Zhang J,Harrison JS,Studzinski GP

    更新日期：2009-10-01 00:00:00

  • Comparison of cyclosporin A, verapamil, PSC-833 and cremophor EL as enhancing agents of VP-16 in murine lymphoid leukemias.

    abstract：:Although verapamil, cyclosporin A. cremophor EL and PSC-833 are active as multidrug resistance modulators, there has been limited study of these compounds as possible chemotherapy enhancing agents against drug-sensitive tumors. We compared these agents as modifiers of VP-16 cytotoxicity in vitro and modifiers of VP-16...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(95)00029-n

    authors： Slater L,Sweet P,Wetzel M,Stupecky M,Osann K

    更新日期：1995-08-01 00:00:00

  • Prognostic impact of combined NPM1+/FLT3- genotype in patients with acute myeloid leukemia with intermediate risk cytogenetics stratified by age and treatment modalities.

    abstract：:The prognostic impact of combined NPM1+/FLT3- genotype is not well defined in elderly patients with acute myeloid leukemia (AML), and in the setting of different treatments, such as cytotoxic chemotherapy (Chemo), hematopoietic cell transplantation (HCT), or hypomethylating agents (HMA). Eighty-two elderly (age >60 ye...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2015.09.001

    authors： Hefazi M,Siddiqui M,Patnaik M,Wolanskyj A,Alkhateeb H,Zblewski D,Elliott M,Hogan W,Litzow M,Al-Kali A

    更新日期：2015-09-03 00:00:00

  • Abnormal expression of the programmed cell death 5 gene in acute and chronic myeloid leukemia.

    abstract：:To clarify whether expression of the programmed cell death 5 (PDCD5) gene in leukemic cells is abnormal, real-time quantitative reverse transcription polymerase chain reaction (RQ-RT-PCR) was used to examine its expression in marrow cells from leukemia patients. We found lower PDCD5 in both AML and CML marrow cells th...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.12.028

    authors： Ruan GR,Qin YZ,Chen SS,Li JL,Ma X,Chang Y,Wang YZ,Fu JY,Liu YR

    更新日期：2006-09-01 00:00:00

  • Variant cell lines from the human promyelocyte line HL60.

    abstract：:The continuous human promyeloid cell line HL60 may be induced to differentiate into neutrophils by the presence of 1.25% dimethylsulphoxide (DMSO) and related compounds [4]. When treated with 12-O-tetradecanoylphorbol-13-acetate (TPA), the cells exhibit may features characteristic of monocytes/macrophages [13]. In bot...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(82)90006-6

    authors： Toksoz D,Bunce CM,Stone PC,Michell RH,Brown G

    更新日期：1982-01-01 00:00:00

  • CD14 mediated endogenous TNF-alpha release in HL60 AML cells: a potential model for CD14 mediated endogenous cytokine release in the treatment of AML.

    abstract：:In previous studies, HL60 AML cells treated with tumor necrosis factor-alpha (TNF), interferon-gamma (IFN), and lipopolysaccharides (LPS) displayed decreased growth and viability, enhanced monocytic pathway differentiation and endogenous TNF release. Endogenous TNF release by LPS/TNF/IFN treated HL60 cells was postula...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(94)90004-3

    authors： Treon SP,Anand B,Ulevitch R,Broitman SA

    更新日期：1994-01-01 00:00:00

  • Myelodysplastic syndrome with transformation to acute monocytic leukemia with FLT3-ITD mutation following orthotopic liver transplantation.

    abstract：:A rare case of a 46-year-old man who underwent myelodysplastic syndrome, acute monocytic leukemia with FLT3-ITD mutation and splenic disruption following orthotopic liver transplantation is reported. The study of this case may be helpful to understand both the pathogenesis of acute leukemia and new complication of liv...

    journal_title：Leukemia research

    pub_type： 信件

    doi：10.1016/j.leukres.2005.11.025

    authors： Zhang GS,Dai CW,Peng HL,Xu YX,Pei MF

    更新日期：2006-07-01 00:00:00

  • Phenotypic and functional characterization of mobilized peripheral blood CD34+ cells coexpressing different levels of c-Kit.

    abstract：:In this report we evaluated the exact expression pattern of c-Kit on mobilized peripheral blood (PB) CD34+ cells. Using a monoclonal antibody against CD117 antigen (95C3), flow cytometric analysis revealed that approximately 25% of the mobilized PB CD34+ cells coexpress c-Kit. This cell fraction showed a considerable ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(98)00002-2

    authors： Kuçi S,Taylor G,Neu S,Schumm M,Niethammer D,Handgretinger R

    更新日期：1998-04-01 00:00:00

  • Prognostic classification of patients with acute lymphoblastic leukemia by using gene copy number profiles identified from array-based comparative genomic hybridization data.

    abstract：:The development of risk-adapted therapy has improved the treatment results of acute lymphoblastic leukemia (ALL) especially in children. However, more accurate risk classifiers are warranted. In this study we aimed at defining a prognostic classifier based on DNA copy number alterations of adolescent and young adult (...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2010.02.031

    authors： Usvasalo A,Elonen E,Saarinen-Pihkala UM,Räty R,Harila-Saari A,Koistinen P,Savolainen ER,Knuutila S,Hollmén J

    更新日期：2010-11-01 00:00:00

  • Phosphorylation of spleen tyrosine kinase at tyrosine 348 (pSyk³⁴⁸) may be a marker of advanced phase of Chronic Myeloid Leukemia (CML).

    abstract：:We investigated Syk as a potential marker of CML progression. We observed a significant over-expression of Syk mRNA and constitutive phosphorylation of Syk Y348 in blast cells from six AP or BP-CML, but not in 15 CML in chronic phase. We could follow in vivo the recurrence of pSyk(348) throughout blast cell escape, de...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2014.11.014

    authors： Bourgne C,Janel A,Berger J,Rapatel C,Tournilhac O,Hermet E,Guerci A,Lioret F,Briançon A,Bamdad M,Boiret-Dupré N,Berger MG

    更新日期：2015-03-01 00:00:00

  • Effects of X-irradiation, ovariohysterectomy and estradiol-17 beta on incidence, benign/malignant ratio and multiplicity of rat mammary neoplasms--a preliminary report.

    abstract：:An overview is given of the effects of X-irradiation, ovariohysterectomy and estradiol-17 beta administration on mammary tumorigenesis in females of 3 rat strains, viz. the WAG/Rij, BN/BiRij and SD. The 3 rat strains differed significantly in their spontaneous mammary tumor incidence. Female SD rats had the highest in...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(86)90292-4

    authors： Solleveld HA,van Zwieten MJ,Broerse JJ,Hollander CF

    更新日期：1986-01-01 00:00:00

  • c-Myc and E2F1 drive PBK/TOPK expression in high-grade malignant lymphomas.

    abstract：:c-Myc has been implicated in a variety of hematologic malignancies including Burkitt's lymphoma. Targeting c-Myc driven growth pathways could be therapeutically useful but might require the identification of critical downstream proteins. Here we show that the serine-threonine kinase PBK/TOPK is frequently overexpresse...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2012.11.010

    authors： Hu F,Gartenhaus RB,Zhao XF,Fang HB,Minkove S,Poss DE,Rapoport AP

    更新日期：2013-04-01 00:00:00

  • Expression of the testis-specific gene, TSGA10, in Iranian patients with acute lymphoblastic leukemia (ALL).

    abstract：:Testis-specific gene antigen (TSGA10) is expressed in fetus, testis and frequently in human solid cancers and acute leukemias, making it a candidate for immunotherapy and for detection of minimal residual disease (MRD). This gene is considered as a member of cancer-testis (CT) genes. We previously demonstrated TSGA10 ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.11.012

    authors： Mobasheri MB,Modarressi MH,Shabani M,Asgarian H,Sharifian RA,Vossough P,Shokri F

    更新日期：2006-07-01 00:00:00

  • S-phase DNA content and aneuploidy of immunophenotypic defined subpopulations in acute myeloid leukemia determined by multi-parameter flow cytometry.

    abstract：:One of the major limitations of DNA flow cytometry (FCM) in hematologic malignancies is the lack of information about the proliferation activity of subpopulations of the heterogeneous bone marrow (BM) compartment. We studied the S-phase DNA content of immunophenotypically defined BM subpopulations (CD2+; CD19+; CD2/CD...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(91)90467-8

    authors： Brons P,Pennings A,Haanen C,Wessels H,Boezeman J

    更新日期：1991-01-01 00:00:00

  • The in vivo distribution of indium-111 labeled in vitro alloactivated syngeneic lymphocytes in a patient with relapsed acute myelomonocytic leukemia: implications for adoptive chemoimmunotherapy.

    abstract：:A single patient who had a leukemic relapse six months after receiving a syngeneic bone marrow transplant was given "adoptive chemoimmunotherapy." Lymphocytes from the patients identical twin were alloactivated and grown in T cell growth factor in vitro. After receiving chemotherapy to reduce the number of relapsed le...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(84)90110-3

    authors： Sondel PM,Kohler PC,Hank JA,Bozdech MJ,Lieberman LM,Hong R,Albertini R,Exten RE

    更新日期：1984-01-01 00:00:00

  • Effect of thymosin and phorbol ester on purine metabolic enzymes and cell surface phenotype in a malignant T-cell line (MOLT-3).

    abstract：:Previous studies have shown that thymosin (fraction 5) is able to induce surface differentiation markers on normal murine bone marrow T-cell precursors. Phorbol ester (TPA) promotes differentiation of human leukaemic lymphoblasts as assessed by changes in phenotypic surface markers and terminal deoxynucleotidyl transf...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(83)90072-3

    authors： Ho AD,Ma DD,Price G,Hoffbrand AV

    更新日期：1983-01-01 00:00:00

  • SDF-1/CXCR4 axis in myelodysplastic syndromes: correlation with angiogenesis and apoptosis.

    abstract：:To study the role of SDF-1/CXCR4 axis in MDS, the expression of SDF-1 and CXCR4, VEGF, MVD and apoptosis were measured in MDS. The results showed that the expression of SDF-1 of the low-grade MDS is higher than that of the high-grade MDS and the control. The high-grade MDS had a significantly higher CXCR4 expression o...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2011.06.017

    authors： Zhang Y,Zhao H,Zhao D,Sun L,Zhi Y,Wu X,Huang W,Da W

    更新日期：2012-03-01 00:00:00

  • Validation of the revised international prognostic scoring system (IPSS-R) in patients with myelodysplastic syndrome: a multicenter study.

    abstract：:The revised IPSS (IPSS-R) was developed aiming at a better prognostication, taking into account patients treated with best supportive care. We herein validated this model on the basis of data from 1314 patients who received BSC only as well as patients who underwent induction chemotherapy (n=214) or allogeneic transpl...

    journal_title：Leukemia research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.leukres.2013.10.013

    authors： Neukirchen J,Lauseker M,Blum S,Giagounidis A,Lübbert M,Martino S,Siragusa S,Schlenk RF,Platzbecker U,Hofmann WK,Götze K,Palumbo GA,Magrin S,Kündgen A,Aul C,Hildebrandt B,Hasford J,Kobbe G,Haas R,Germing U

    更新日期：2014-01-01 00:00:00

  • Platelet transfusion refractoriness in patients with acute myeloid leukemia treated by intensive chemotherapy.

    abstract：:Platelet transfusion refractoriness (PTR) is a major adverse event in the management of acute myeloid leukemia (AML). In a series of 897 adult patients with AML receiving intensive chemotherapy, we identified 41 patients (4.8%) with PTR. PTR was more frequently observed in parous women, patients with extra-medullary d...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2017.08.015

    authors： Comont T,Tavitian S,Bardiaux L,Fort M,Debiol B,Morère D,Bérard E,Delabesse E,Luquet I,Martinez S,Huguet F,Récher C,Bertoli S

    更新日期：2017-10-01 00:00:00

  • Differential effect of heat shock on RNA metabolism in human Burkitt's lymphoma B-cell lines.

    abstract：:Thermal stress induces expression of a family of heat shock proteins which may regulate the synthesis of various cellular genes. We investigated the effect of heat shock on polyadenylation in Epstein-Barr Virus (EBV) negative and EBV transformed human Burkitt's lymphoma (BL) B-cell lines. Incubation of the BL B-cell l...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(95)00063-1

    authors： Kumar A,Kurl RN,Kryworuchko M,Diaz-Mitoma F,Sharma S

    更新日期：1995-11-01 00:00:00

  • Analysis of clonality at the level of progenitors in chronic myelogenous leukaemia using the polymerase chain reaction.

    abstract：:The Philadelphia (Ph1) chromosome is a specific structural abnormality in which the abl oncogene is activated due to the formation of the novel chimeric gene, bcr/abl. To investigate the clinicopathological role of bcr/abl in Ph1-positive chronic myelogenous leukaemia (CML), we studied the clonal origin of haematopoie...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(92)90139-x

    authors： Sadamura S,Umemura T,Takahira H,Hirata J,Nishimura J,Nawata H

    更新日期：1992-01-01 00:00:00

  • Semenogelin I expression in myeloma cells can be upregulated pharmacologically.

    abstract：:Semenogelin (SEMG) I is a Cancer-Testis (CT) antigen that we have found to be expressed in myeloma cells. In this study, we set out to determine whether the expression of SEMG I could be upregulated pharmacologically. We found that SEMG I expression in myeloma cells can be upregulated by 5-azacytidine, IL-4 and IL-6. ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2008.03.036

    authors： Zhang Y,Wang Z,Zhang J,Farmer B,Lim SH

    更新日期：2008-12-01 00:00:00

  • Compound 48, a novel dual PPAR alpha/gamma ligand, inhibits the growth of human CML cell lines and enhances the anticancer-effects of imatinib.

    abstract：:Compound 48 (C48) is a novel dual ligand for peroxisome proliferator-activated receptor alpha and gamma (PPAR alpha/gamma). Culture of imatinib-sensitive and -resistant CML cell lines with C48 resulted in a strong growth inhibition which associated with G0/G1 cell cycle arrest. However, it showed no obvious toxicity t...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2008.11.023

    authors： Bertz J,Zang C,Liu H,Wächter M,Possinger K,Koeffler HP,Elstner E

    更新日期：2009-05-01 00:00:00

  • Aberrant expression of tumor suppressor genes and their association with chimeric oncogenes in pediatric acute lymphoblastic leukemia.

    abstract：:Aberrant expression of tumor suppressor genes WT 1, RB 1, p53, homozygous deletion of p16 gene and their relationship with expression of oncogenes BCR-ABL, TEL-AML 1, MLL-AF 4, E2A-PBX 1, SIL-TAL 1 were determined in bone marrow samples of children with de novo B-lineage (n=170) and T-lineage (n=25) acute lymphoblasti...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.04.006

    authors： Kustanovich AM,Savitskaja TV,Bydanov OI,Belevtsev MV,Potapnev MP

    更新日期：2005-11-01 00:00:00

  • Aven overexpression: association with poor prognosis in childhood acute lymphoblastic leukemia.

    abstract：:Aven expression has recently been identified as an anti-apoptotic protein. In this study, Aven expression in 91 children with acute lymphoblastic leukemia (ALL) was investigated for possible correlation with clinical features at diagnosis and treatment outcome. Aven expression was found to be higher in patients >or=10...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.11.001

    authors： Choi J,Hwang YK,Sung KW,Kim DH,Yoo KH,Jung HL,Koo HH

    更新日期：2006-08-01 00:00:00

  • Assessing signaling pathways associated with in vitro resistance to cytotoxic agents in AML.

    abstract：:This study uses single cell network profiling (SCNP) to characterize biological pathways associated with in vitro resistance or sensitivity to chemotherapeutics commonly used in acute myeloid leukemia (AML) (i.e. cytarabine/daunorubicin, gemtuzumab ozogamicin (GO), decitabine, azacitidine, clofarabine). Simultaneous m...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2012.02.022

    authors： Rosen DB,Cordeiro JA,Cohen A,Lacayo N,Hogge D,Hawtin RE,Cesano A

    更新日期：2012-07-01 00:00:00

  • Distinct cellular origins of primary effusion lymphoma with and without EBV infection.

    abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with three distinct lymphoproliferative disorders: primary effusion lymphoma (PEL), multicentric Castleman's disease (MCD) and germinotropic lymphoproliferative disorder (GLD). KSHV positive lymphocytes in GLD and in most cases of PEL are co-infected by Epst...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2003.08.003

    authors： Hamoudi R,Diss TC,Oksenhendler E,Pan L,Carbone A,Ascoli V,Boshoff C,Isaacson P,Du MQ

    更新日期：2004-04-01 00:00:00

  • On the biochemical modulation of 6-mercaptopurine by methotrexate in murine WEHI-3b leukemia cells in vitro.

    abstract：:The chemicals 6-mercaptopurine (6-MP) and methotrexate (MTX) are the cornerstones in the maintenance treatment of acute lymphoblastic leukemia. The intracellular metabolism of 6-MP to 6-thioguanosine nucleotides (TGN) via 6-thioinosine 5'-monophosphate (TIMP) is crucial for its cytotoxic effect. MTX inhibits purine de...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(92)90065-f

    authors： Liliemark J,Pettersson B,Peterson C

    更新日期：1992-01-01 00:00:00

  • Glycosylation interference on RhoA activation: focus on G-CSF.

    abstract：:Glycosylation of cytokines appears to be responsible for several differences in their activity, and focusing on G-CSF, several divergences between the non-glycosylated G-CSF, Filgrastim, and the glycosylated G-CSF, Lenograstim, have been reported. To verify the role of G-CSF glycosylation in mediating these difference...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2010.05.027

    authors： Mattii L,Battolla B,Azzarà A,D'Urso G,Montali U,Petrini M

    更新日期：2011-02-01 00:00:00