The in vivo distribution of indium-111 labeled in vitro alloactivated syngeneic lymphocytes in a patient with relapsed acute myelomonocytic leukemia: implications for adoptive chemoimmunotherapy.

abstract：:Rearrangements in MLL (MLL-r) are common within very young children with leukemia and affect the prognosis and treatment. Previous studies have suggested the use of the NG2 molecule as a marker for MLL-r but these studies were performed using a small number of infants. We analyzed 148 patients (all less than 24 months...

journal_title：Leukemia research

authors： Emerenciano M,Renaud G,Sant'Ana M,Barbieri C,Passetti F,Pombo-de-Oliveira MS,Brazilian Collaborative Study Group of Infant Acute Leukemia.

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Therapy strategies for myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) vary considerably. OBJECTIVE:To review the treatment of Brazilian children who were diagnosed with MDS or JMML in the past decade and reported to the Brazilian Cooperative Group on Pediatric Myelodysplastic Sy...

journal_title：Leukemia research

authors： Valera ET,Latorre Mdo R,Mendes WL,Seber A,Lee ML,de Paula MJ,Loggetto SR,Velloso E,Niero-Melo L,Lopes LF,Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes.

更新日期：2004-09-01 00:00:00

abstract：:Nasal-type natural killer/T-cell (NK/T-cell) lymphomas are subtypes of non-Hodgkin's lymphoma (NHL), which are typically more clinically aggressive. There is, however relatively little understanding of nasal-type NK/T-cell lymphoma molecular pathogenesis. Thus, in this study we applied RNA sequencing to systematically...

journal_title：Leukemia research

authors： Zhang X,Zhao L,Li X,Wang X,Li L,Fu X,Sun Z,Li Z,Nan F,Chang Y,Zhang M

更新日期：2015-12-01 00:00:00

abstract：:We report the characterization of a novel human T-cell line, HPB-MLp-W, which was established from blastic cells of a lymph node specimen from a patient with non-Hodgkin's lymphoma. They demonstrated the T-cell association antigens, CD2 and CD4, but no CD3, CD8, CD1, CD5, CD7 nor T-cell antigen receptor on their cell ...

journal_title：Leukemia research

authors： Morikawa S,Morikawa K,Hara J,Nagasaki M,Nakano A,Oseko F

更新日期：1991-01-01 00:00:00

abstract：:The resistance to all trans retinoic acid (ATRA) differentiating treatment is a consequence, in most of the cases, of either increased catabolism or down regulation of ATRA uptake. Recently, we have shown that ATRA efficiency to differentiate HL-60 cells was enhanced about 30 times after its incorporation into Low Den...

journal_title：Leukemia research

authors： Gueddari N,Madoulet C,Lefebvre P,Berthou L,Chomienne C,Jardillier JC

更新日期：2000-06-01 00:00:00

abstract：:In vivo infection by HTLV-I is characterized by the lack of virus expression in the host's infected cells and in most cases it is clinically inapparent. The present study shows that exposure of HTLV-I-infected human T-cells to a maximal non-toxic dose of 3-MC remarkably enhances virus expression. This stimulatory effe...

journal_title：Leukemia research

authors： Feldman G,Aboud M

更新日期：1993-05-01 00:00:00

abstract：:Helix-loop-helix (HLH) transcription factors are involved in cellular growth and differentiation. The Id (inhibitor of DNA binding and differentiation) HLH proteins, in a dominantly negative fashion, regulate transcriptional activities of basic HLH proteins. We examined by northern hybridization the expression of Id2 ...

journal_title：Leukemia research

authors： Ishiguro A,Spirin K,Shiohara M,Tobler A,Norton JD,Rigolet M,Shimbo T,Koeffler HP

更新日期：1995-12-01 00:00:00

abstract：:Aneuploidy is a very common prognostic factor in multiple myeloma (MM). Nonhyperdiploidy including near-tetraploidy (NT) is a poor prognostic indicator, compared to hyperdiploidy in multiple myeloma (MM). NT results from endoduplication of hypodiploidy. We report of a 55-year-old female patient diagnosed with advanced...

journal_title：Leukemia research

authors： Yuan J,Shah R,Kulharya A,Ustun C

更新日期：2010-07-01 00:00:00

abstract：:Atypical chronic myeloid leukemia (aCML) and chronic neutrophilic leukemia (CNL) are rare BCR-ABL1 fusion gene-negative myeloid neoplasms with a predominance of neutrophils. Since no standard therapeutic strategy currently exists for these diseases, we retrospectively evaluated the outcomes of allogeneic hematopoietic...

journal_title：Leukemia research

authors： Itonaga H,Ota S,Ikeda T,Taji H,Amano I,Hasegawa Y,Ichinohe T,Fukuda T,Atsuta Y,Tanizawa A,Kondo T,Miyazaki Y

更新日期：2018-12-01 00:00:00

abstract：:Forty patients with high risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) preceded by MDS were treated with intensive induction and consolidation chemotherapy in a prospective multicenter pilot study. They were given two cycles of cytarabine 100 mg/m with 12-h intervals on days 1-7 and idarubicin 12...

journal_title：Leukemia research

authors： Ruutu T,Hänninen A,Järventie G,Koistinen P,Koivunen E,Kätkä K,Nousiainen T,Oksanen K,Pelliniemi TT,Remes K,Timonen T,Volin L,Elonen E

更新日期：1997-02-01 00:00:00

abstract：:Induction of granulocyte maturation in HL-60 leukemic cells by DMSO (1.2%) or RA (1 microM) is accompanied by a 50-60% decrease in cellular thymidine kinase activity. Similarly, the differentiation of HL-60 cells into monocyte-macrophage phenotype by the addition of PMA is paralleled by a 60-80% suppression of thymidi...

journal_title：Leukemia research

authors： Borelli TJ,Miyamoto S,Wertheimer SJ,Wu JM

更新日期：1987-01-01 00:00:00

abstract：:To determine the incidence of haematological malignancies in French Polynesia from 1990 to 1995, we collected cases from the local cancer registry, sanitary evacuation files and all the histopathology and clinical biology laboratories. All leukaemias, non Hodgkin's lymphomas, and multiple myelomas incidence was slight...

journal_title：Leukemia research

authors： Roda L,de Vathaire F,Rio B,Le Tourneau A,Petididier P,Laudon F,Zittoun R

更新日期：1999-04-01 00:00:00

abstract：:The MTT cell viability assay is widely used in determining drug sensitivity profiles for patients with hematological malignancies and in primary screening of potential chemotherapeutic drugs. Because the multidrug resistance (MDR) phenotype is associated with these malignancies, and since many vital dyes are effluxed ...

journal_title：Leukemia research

authors： Marks DC,Belov L,Davey MW,Davey RA,Kidman AD

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Most patients with myelodysplastic syndromes (MDS) require transfusions at the risk of iron overload and associated organ damage, and death. Emerging evidence indicates that iron chelation therapy (ICT) could reduce mortality and improve survival in transfusion-dependent MDS patients, especially those classi...

journal_title：Leukemia research

authors： Delforge M,Selleslag D,Beguin Y,Triffet A,Mineur P,Theunissen K,Graux C,Trullemans F,Boulet D,Van Eygen K,Noens L,Van Steenweghen S,Lemmens J,Pierre P,D'hondt R,Ferrant A,Deeren D,Van De Velde A,Wynendaele W,André M

更新日期：2014-05-01 00:00:00

abstract：:Introduction of the maturation index (MI) as a measure for the degree of maturation improved the subtyping of acute myeloid leukemia (AML). A comparison is made here between the MI and the results of surface marker analysis with a panel of monoclonal antibodies (McAb) in the immunofluorescence technique. The McAb appl...

journal_title：Leukemia research

authors： van Rhenen DJ,van der Reijden HJ,van't Veer MB,Engelfriet CP,von dem Borne AE,Langenhuijsen MM

更新日期：1983-01-01 00:00:00

abstract：:Although abnormalities in granulopoiesis detected by means of bone marrow cytology, culture and kinetic studies have provided prognostic data in preleukemic states and oligoblastic leukemias, this information cannot be applied to individual cases. In order to determine the indications for treatment and the form it sho...

journal_title：Leukemia research

authors： Karsdorf A,Dresch C,Metral J,Najean Y

更新日期：1983-01-01 00:00:00

abstract：:The association between seven polymorphisms in the genes hOCT1 and MDR1, encoding for imatinib transporter proteins, and the response to imatinib 400mg/daily was investigated in 65 patients newly diagnosed with chronic-phase chronic myeloid leukemia. The AA genotype at the rs6935207 hOCT1 polymorphic locus was not det...

journal_title：Leukemia research

authors： Maffioli M,Camós M,Gaya A,Hernández-Boluda JC,Alvarez-Larrán A,Domingo A,Granell M,Guillem V,Vallansot R,Costa D,Bellosillo B,Colomer D,Cervantes F

更新日期：2011-08-01 00:00:00

abstract：:Limited information is available on the relationship between expression of some additional aberrant phenotypic features and outcome of acute promyelocytic leukemia (APL) patients. Here, we set out to assess the frequency of CD15 and CD56 expression, and their prognostic value in a large series of APL patients. One hun...

journal_title：Leukemia research

authors： Breccia M,De Propris MS,Minotti C,Stefanizzi C,Raponi S,Colafigli G,Latagliata R,Guarini A,Foà R

更新日期：2014-02-01 00:00:00

abstract：:K-562 is described as a pluripotent leukemic cell line which expresses a diversity of hematopoietic cell differentiation antigens. With the use of monoclonal antibodies (MoAb), we show that the expression of these antigens is either "modulated", i.e. they are not expressed in early logarithmic growth but are expressed...

journal_title：Leukemia research

authors： Ichiki AT,Lozzio CB,Bamberger EG,Lucas PB,Wust CJ,Fuhr JE

更新日期：1987-01-01 00:00:00

abstract：:The impact of genetic aberrations on rituximab-based therapeutic regimens has been intensely studied in chronic lymphocytic leukemia (CLL). According to the current consensus chemoimmunotherapy consisting of rituximab and DNA-damaging drugs is not suitable for patients with TP53 defects. In our study, we focused on CL...

journal_title：Leukemia research

authors： Spunarova M,Tom N,Pavlova S,Mraz M,Brychtova Y,Doubek M,Panovska A,Skuhrova Francova H,Brzobohata A,Pospisilova S,Mayer J,Trbusek M

更新日期：2019-06-01 00:00:00

abstract：:To highlight dasatinib role in the elderly, 125 unselected patients with CP-CML aged >60 years resistant/intolerant to imatinib were retrospectively evaluated. Grade 3-4 haematological and extra-haematological toxicities were reported in 39 (31.2%) and 34 (27.2%) patients; grade 3-4 haematological toxicity was higher ...

journal_title：Leukemia research

authors： Latagliata R,Breccia M,Castagnetti F,Stagno F,Luciano L,Gozzini A,Ulisciani S,Cavazzini F,Annunziata M,Sorà F,Rossi AR,Pregno P,Montefusco E,Abruzzese E,Crisà E,Musto P,Tiribelli M,Binotto G,Occhini U,Feo C,Vigner

更新日期：2011-09-01 00:00:00

abstract：:Aggressive systemic mastocytosis (ASM) is a hematopoietic neoplasm characterized by infiltration of visceral organs by neoplastic mast cells (MCs) with consecutive organopathy and respective clinical and laboratory findings (so called C-Findings). Whereas, it is generally appreciated that patients with ASM are candida...

journal_title：Leukemia research

authors： Hauswirth AW,Simonitsch-Klupp I,Uffmann M,Koller E,Sperr WR,Lechner K,Valent P

更新日期：2004-03-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with three distinct lymphoproliferative disorders: primary effusion lymphoma (PEL), multicentric Castleman's disease (MCD) and germinotropic lymphoproliferative disorder (GLD). KSHV positive lymphocytes in GLD and in most cases of PEL are co-infected by Epst...

journal_title：Leukemia research

authors： Hamoudi R,Diss TC,Oksenhendler E,Pan L,Carbone A,Ascoli V,Boshoff C,Isaacson P,Du MQ

更新日期：2004-04-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation, t(15;17) (q22;q12), resulting in fusion of the genes promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA). With conventional cytogenetic methods, these translocations are detected in about 70-90% of patients, with most o...

journal_title：Leukemia research

authors： Han JY,Kim KE,Kim KH,Park JI,Kim JS

更新日期：2007-02-01 00:00:00

abstract：:A patient with myelodysplastic syndromes (MDS) developed eosinophilia during treatment with recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF). To study the mechanism of this eosinophilia, we investigated the proliferation of eosinophil colony-forming units (CFU-Eo) in nine patients and four...

journal_title：Leukemia research

authors： Koike M,Ishiyama T,Yokoyama A,Kawakami K,Nakamaki T,Tomoyasu S,Tsuruoka N

更新日期：1995-12-01 00:00:00

abstract：:Although biological and clinical features differ between B-lineage acute lymphoblastic leukemia (ALL) and T-lineage ALL (T-ALL), there have been few reports that focused on the prognosis for T-ALL in adults, primarily due to its rarity. Here, we studied the long-term outcomes and prognostic factors specific for adult ...

journal_title：Leukemia research

authors： Yanada M,Jinnai I,Takeuchi J,Ueda T,Miyawaki S,Tsuzuki M,Hatta Y,Usui N,Wada H,Morii T,Matsuda M,Kiyoi H,Okada M,Honda S,Miyazaki Y,Ohno R,Naoe T

更新日期：2007-07-01 00:00:00

abstract：:Imatinib mesylate (IM) is the treatment of choice in patients with newly diagnosed chronic myeloid leukemia (CML), irrespectively of their age. Nevertheless, information regarding tolerability and responses in advanced-age patients, a subgroup in which co-morbidities and other factors may influence outcome, is scarce,...

journal_title：Leukemia research

authors： Sánchez-Guijo FM,Durán S,Galende J,Boqué C,Nieto JB,Balanzat J,Gracia A,García I,Avellaneda-Molina C,Moreno MV,Luño-Fernandez E,Hermosilla M,Sanchez-Varela JM,Dios A,López-Garrido P,Giraldo P,Bargay J,Domingo JM,Soler

更新日期：2011-09-01 00:00:00

abstract：:We studied 98 female patients in remission (2-240 months) from childhood ALL to determine the clonality status of their hematopoiesis. Thirty-one (31.6%) were heterozygous at the PGK locus for the BstX1 endonuclease restriction site, permitting X-linked clonality assays to be performed. Two patients were in relapse at...

journal_title：Leukemia research

authors： Busque L,Ilaria R Jr,Tantravahi R,Weinstein H,Gilliland DG

更新日期：1994-02-01 00:00:00

abstract：:We examined the effect of deferasirox (DFX) on CD34+ hematopoietic progenitors from MDS patients. Progressive, dose-dependent suppression of MDS progenitor proliferation in culture was observed with DFX concentrations ranging from 5 μM to 20 μM. This effect was more pronounced in MDS compared to CD34+ progenitors isol...

journal_title：Leukemia research

authors： Pullarkat V,Sehgal A,Li L,Meng Z,Lin A,Forman S,Bhatia R

更新日期：2012-08-01 00:00:00

abstract：:The incidence of B cell chronic lymphocytic leukemia (B-CLL) is lower in Asian countries, including India, when compared with Western countries. The bcl-2 gene rearrangement was restricted to the 5' region and seen in only one of the 20 Indian patients analyzed. The incidence remains similar to that reported from West...

journal_title：Leukemia research

authors： Parikh PM,Desai S,Naresh KN,Shakuntaka B,Laxminarayan K,Nair CN,Ladanyi M,Soman CS,Advani SH,Chaganti RS

更新日期：1996-09-01 00:00:00