Abstract:
:To highlight dasatinib role in the elderly, 125 unselected patients with CP-CML aged >60 years resistant/intolerant to imatinib were retrospectively evaluated. Grade 3-4 haematological and extra-haematological toxicities were reported in 39 (31.2%) and 34 (27.2%) patients; grade 3-4 haematological toxicity was higher in patients with 140 mg starting dose (50.0% vs 19.6%, p=0.001). Grade 3-4 pleuro-pericardial effusions occurred in 10 patients (8.0%). Dose reductions were more common in patients with 140 mg (88.4% vs 26.7%, p<0.001). Of 122 evaluable patients, 72 (59.1%) had cytogenetic response [12 (9.8%) partial, 60 (49.3%) complete]. Overall, 38/60 patients in complete CyR also achieved a molecular response. Cumulative OS at 24 and 48 months were 93.1% (95% CI 88.4-97.8) and 84.2% (95% CI 74.6-93.7). Dasatinib, at the recommended dose of 100mg/day, is effective and safe also in unselected elderly subjects.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Latagliata R,Breccia M,Castagnetti F,Stagno F,Luciano L,Gozzini A,Ulisciani S,Cavazzini F,Annunziata M,Sorà F,Rossi AR,Pregno P,Montefusco E,Abruzzese E,Crisà E,Musto P,Tiribelli M,Binotto G,Occhini U,Feo C,Vignerdoi
10.1016/j.leukres.2011.05.015subject
Has Abstractpub_date
2011-09-01 00:00:00pages
1164-9issue
9eissn
0145-2126issn
1873-5835pii
S0145-2126(11)00232-3journal_volume
35pub_type
杂志文章,多中心研究abstract::The effect of prostaglandin E2 (PGE2) on the reduction of c-myc expression during the differentiation of the human leukemic cell line, HL-60, was examined. PGE2, a potent inducer of intracellular cyclic AMP (cAMP) in HL-60 cells, augmented monocyte-associated cell surface antigens induced by human gamma-interferon (IF...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(88)90090-2
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journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2004.04.017
更新日期:2005-01-01 00:00:00
abstract::The impact of genetic aberrations on rituximab-based therapeutic regimens has been intensely studied in chronic lymphocytic leukemia (CLL). According to the current consensus chemoimmunotherapy consisting of rituximab and DNA-damaging drugs is not suitable for patients with TP53 defects. In our study, we focused on CL...
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abstract::We examined the effect of deferasirox (DFX) on CD34+ hematopoietic progenitors from MDS patients. Progressive, dose-dependent suppression of MDS progenitor proliferation in culture was observed with DFX concentrations ranging from 5 μM to 20 μM. This effect was more pronounced in MDS compared to CD34+ progenitors isol...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2012.03.018
更新日期:2012-08-01 00:00:00
abstract::We have studied 35 adult patients with morphologically undifferentiated peroxidase-negative acute leukemia that failed to meet the criteria for acute lymphoblastic leukemia and compared them to patients with FAB M1-M7 seen by the same physicians. The diagnosis of minimally differentiated acute leukemia (MD-AL) was ass...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(93)90002-3
更新日期:1993-03-01 00:00:00
abstract::Higher-risk myelodysplastic syndromes (MDS) are rarely curable and have a poor prognosis. We investigated the accuracy of physicians' perception of patients' health status and the patients' preferences for involvement in treatment decisions. We examined 280 newly diagnosed higher-risk elderly MDS patients paired with ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2015.05.012
更新日期:2015-08-01 00:00:00
abstract::A double monoclonal component (MC) detected in the serum and/or urine represents a very rare occurrence (2-6% of monoclonal gammopathies). In this study, we report 34 patients with double serum MCs, focusing on the associated diseases. The diagnosis was made using high-resolution serum protein electrophoresis and immu...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2012.05.008
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doi:10.1016/j.leukres.2010.06.024
更新日期:2011-01-01 00:00:00
abstract::Flow cytometry is commonly used to establish the diagnosis of chronic lymphocytic leukemia (CLL). A defined combination of antibodies discriminates between normal B cells and CLL cells (coexpression of CD5, CD19, and CD23). The receptor tyrosine-like orphan receptor one (ROR1) is an embryonic glycoprotein involved in ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2011.04.006
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abstract::We determined the position of the breakpoint within the bcr gene in 22 patients with Philadelphia-positive chronic myelocytic leukemia using conventional Southern-blots and analyzed its relationship to thrombopoiesis. After DNA digestion with restriction endonucleases (Hind III, Bam HI and Bgl II), we localized the br...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(91)90113-8
更新日期:1991-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2004.03.017
更新日期:2004-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(84)90084-5
更新日期:1984-01-01 00:00:00
abstract::Over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), playing a role in leukemogenesis while decreased expression of PU.1 induces AML in mice model. Therefore, we speculated that there is an inverse relationship between these two factors. To clarify this, we measured the expression level of Fl...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2005.07.015
更新日期:2006-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00152-7
更新日期:2002-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(99)00101-0
更新日期:1999-10-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(85)90158-4
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(97)00128-8
更新日期:1998-02-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90160-3
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abstract::A permanent cell line, MN 60, was established from the peripheral blood of a patient with an acute lymphoblastic leukemia (ALL) classified morphologically as being of the L3 type. Cell growth started rapidly in vitro and no feeder cells were needed. Cells of the MN-60 line were identical to the original leukemic cells...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(82)90085-6
更新日期:1982-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(94)00151-y
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:The median survival of patients with chronic myelogenous leukemia in myeloid blast crisis (MBC-CML) is poor even for patients treated with tyrosine kinase inhibitors (TKIs). DESIGN AND METHODS:We conducted a dose-escalating study of daunorubicin combined to fixed doses of IM (imatinib mesylate, 600 mg/d) an...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2011-06-01 00:00:00
abstract::A method using avidin-biotin complex (ABC) to detect the presence of the enzyme terminal deoxynucleotidyl transferase (TdT) is described and compared with a proven indirect immunofluorescence method. The material studied consisted of: (1) peripheral blood and bone marrow smears from 17 patients with leukemia (ALL, 8; ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(83)90107-8
更新日期:1983-01-01 00:00:00
abstract::Platelet transfusion refractoriness (PTR) is a major adverse event in the management of acute myeloid leukemia (AML). In a series of 897 adult patients with AML receiving intensive chemotherapy, we identified 41 patients (4.8%) with PTR. PTR was more frequently observed in parous women, patients with extra-medullary d...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.08.015
更新日期:2017-10-01 00:00:00
abstract::One of the major limitations of DNA flow cytometry (FCM) in hematologic malignancies is the lack of information about the proliferation activity of subpopulations of the heterogeneous bone marrow (BM) compartment. We studied the S-phase DNA content of immunophenotypically defined BM subpopulations (CD2+; CD19+; CD2/CD...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(91)90467-8
更新日期:1991-01-01 00:00:00
abstract::We compared the growth-inhibitory effects and inhibition profile of the SRC family kinases (SFKs) of imatinib, dasatinib, nilotinib and INNO-406. Dasatinib exhibited the strongest potency against BCR-ABL with little selectivity over SFKs. Nilotinib exhibited a weaker affinity than the other inhibitors, but was highly ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.11.008
更新日期:2008-06-01 00:00:00