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The induction kinetics of Il-8 messenger RNA in HL60 cells demonstrate the participation of negative-acting gene(s).

Abstract：

:Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells. Ongoing protein synthase does not seem to be required for the initial induction of IL-8 gene expression. However, the rate of transient induction kinetics was modulated by cycloheximide (CHX) indicating that secondary response genes are involved in the regulation of IL-8 RNA levels. Repression of the induced IL8 mRNA by 21 h PMA-treatment was due to reduced transcriptional activity of the gene. In HL60 cells stimulated for 1.5 and 21 h the half-lives of the lL-8 transcripts were markedly increased, suggesting the presence of negatively-acting transcriptional regulator(s).

journal_name

Leuk Res

journal_title

Leukemia research

authors

Meier RW,Niklaus G,Fey MF,Tobler A

doi

10.1016/0145-2126(94)00151-y

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

449-55

issue

7

eissn

0145-2126

issn

1873-5835

pii

014521269400151Y

journal_volume

19

pub_type

杂志文章

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