当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > The addition of daunorubicin to imatinib mesylate in combination with cytarabine improves the response rate and the survival of patients with myeloid blast crisis chronic myelogenous leukemia (AFR01 study).

The addition of daunorubicin to imatinib mesylate in combination with cytarabine improves the response rate and the survival of patients with myeloid blast crisis chronic myelogenous leukemia (AFR01 study).

Abstract：

BACKGROUND:The median survival of patients with chronic myelogenous leukemia in myeloid blast crisis (MBC-CML) is poor even for patients treated with tyrosine kinase inhibitors (TKIs). DESIGN AND METHODS:We conducted a dose-escalating study of daunorubicin combined to fixed doses of IM (imatinib mesylate, 600 mg/d) and cytarabine (200 mg/d for 7 days), followed by hematopoietic stem cell transplantation or maintenance therapy with single-agent IM in patients with MBC-CML at onset or after failure of therapy excluding TKIs. RESULTS:Thirty-six patients were evaluated. Median follow-up is 6.1 years. Daunorubicin was escaladed up to 45 mg/m(2)/d 3 days. Twenty eight patients (77.7%) had hematologic response including 20 patients (55.5%) in complete hematologic response (CHR). Patients who received daunorubicin at 30-45 mg/m(2)/d had higher CHR rates compared to other patients. Median overall survival was 16 months. Overall survival in patients with hematological response was 35.4 months. Better results were observed in patients diagnosed with MBC-CML at onset. CONCLUSIONS:The combination of IM with a standard "3+7" regiment was well tolerated and provided a high response rate. More than 55% of the patients achieved CHR and hematopoietic stem cell transplantation (SCT) was feasible in half of the cases. This trial was registered at www.clinicaltrials.gov as # NCT00219765.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Deau B,Nicolini FE,Guilhot J,Huguet F,Guerci A,Legros L,Pautas C,Berthou C,Guyotat D,Cony-Makhoul P,Gardembas M,Michallet M,Hayette S,Cayuela JM,Weiss IR,Réa D,Castaigne S,Mahon FX,Guilhot F,Rousselot P

doi

10.1016/j.leukres.2010.11.004

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

777-82

issue

6

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(10)00533-3

journal_volume

35

pub_type

临床试验,杂志文章,多中心研究

相关文献

LEUKEMIA RESEARCH文献大全
  • Expression of a 215,000-dalton nuclear envelope protein decreases during cell maturation.

    abstract：:The monoclonal antibody AGF2.3 identifies a nuclear envelope protein expressed at high levels in most transformed cell lines and weakly expressed in or absent from normal tissues and primary cell cultures. Here we report that expression of AGF2.3 antigen relates to the maturation status of cells. When HL60 cells were ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(86)90235-3

    authors： Brown G,Bunce CM,Johnson GD,Lord JM

    更新日期：1986-01-01 00:00:00

  • Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine.

    abstract：:We evaluated the cytotoxicity of dimethylsphingosine (DMS) against four human leukemia cell lines: two acute (HL60 and a multi-drug resistance MDR-positive derivative HL60-dox) and two blast crisis chronic myelogenous leukemias (JFP1, from a treatment refractory patient and K562), and against blasts isolated from 11 l...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(01)00129-1

    authors： Jendiroba DB,Klostergaard J,Keyhani A,Pagliaro L,Freireich EJ

    更新日期：2002-03-01 00:00:00

  • MCP-1 in the cerebrospinal fluid of children with acute lymphoblastic leukemia.

    abstract：BACKGROUND:Monocyte chemoattractant protein-1 (MCP-1) is a member of the CC chemokines. MCP-1 has been previously shown to have a major role in the migration of monocytes towards human leukemic cells, yet it cannot increase cytotoxic effects of monocytes on human leukemic cells. AIM:To determine levels of MCP-1 in the...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2006.01.017

    authors： Eisenkraft A,Keidan I,Bielorai B,Keller N,Toren A,Paret G

    更新日期：2006-10-01 00:00:00

  • Expression of soluble HLA-G in multiple myeloma patients and patients with renal failure.

    abstract：:Human lymphocyte antigen-G (HLA-G) is an immunosuppressive molecule that induces functional silencing of immune component cells and can be responsible for immunosuppression in patients with multiple myeloma (MM). Immune dysfunction is an important feature of MM and leads to infections as well as may promote disease pr...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2012.02.015

    authors： Wlasiuk P,Stec A,Piechnik A,Kaminska W,Dmoszynska A,Ksiazek A,Giannopoulos K

    更新日期：2012-07-01 00:00:00

  • ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type.

    abstract：:The process of B-cell development is characterized by the activation of the unfolded protein response. Under certain circumstances, the unfolded protein response can be manipulated in a cell death-inducing way. Therefore, tackling the unfolded protein response might be an attractive strategy in the treatment of diffus...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2012.08.017

    authors： Boelens J,Jais JP,Vanhoecke B,Beck I,Van Melckebeke H,Philippé J,Bracke M,Jardin F,Brière J,Leroy K,Offner F,Lust S

    更新日期：2013-01-01 00:00:00

  • Transfer of multidrug resistance among acute myeloid leukemia cells via extracellular vesicles and their microRNA cargo.

    abstract：:The treatment of acute leukemia is still challenging due in part to the development of resistance and relapse. This chemotherapeutics resistance is established by clonal selection of resistant variants of the cancer cells. Recently, a horizontal transfer of chemo-resistance among cancer cells via extracellular vesicle...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2017.09.014

    authors： Bouvy C,Wannez A,Laloy J,Chatelain C,Dogné JM

    更新日期：2017-11-01 00:00:00

  • Aspiration biopsy-nucleic acid diagnosis of thyroid malignant lymphoma by vectorette PCR: experience of eight cases.

    abstract：:The usefulness of a new method to detect B-cell monoclonality named VR, which is a combination of the digestion with restriction enzymes and vectorette PCR, in aspiration biopsy-nucleic acid diagnosis (ABND) of thyroid malignant lymphoma was investigated. ABND was performed in 12 patients in whom malignant lymphoma wa...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2007.03.019

    authors： Takano T,Asahi S,Matsuzuka F,Hidaka Y,Yoshida H,Miyauchi A

    更新日期：2008-01-01 00:00:00

  • Dimethyl sulfoxide potentiates death receptor-mediated apoptosis in the human myeloid leukemia U937 cell line through enhancement of mitochondrial membrane depolarization.

    abstract：:Dimethyl sulfoxide (DMSO) is a widely used prototypical chemical inducer of cell differentiation. In the present study, the effects of DMSO on susceptibility of human myeloid leukemia U937 cells towards ligation of distinct death receptors (DRs) were investigated. DMSO sensitized cells towards induction of apoptosis b...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.05.016

    authors： Vondrácek J,Soucek K,Sheard MA,Chramostová K,Andrysík Z,Hofmanová J,Kozubík A

    更新日期：2006-01-01 00:00:00

  • Ca2+/Mg(2+)-dependent endonuclease in marrow CD34 positive and erythroid cells in myelodysplasia.

    abstract：:Endonucleases capable of producing internucleosomal DNA cleavage are one of the key enzymes in apoptosis. We examined endonuclease activities contained in nuclei of CD34+ and erythroid cells in the bone marrow (BM) from 12 patients with the myelodysplastic syndromes. The levels of Mg(2+)-dependent and acidic endonucle...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(97)00041-6

    authors： Anzai N,Kawabata H,Hishita T,Yoshida Y,Ueda Y,Okuma M

    更新日期：1997-08-01 00:00:00

  • Endocrine sequelae and metabolic syndrome in adult long-term survivors of childhood acute myeloid leukemia.

    abstract：:This study focuses on the effect of chemotherapy on endocrinopathies and the metabolic syndrome in adult survivors of childhood acute myeloid leukemia (AML). Endocrine function and metabolic syndrome were evaluated in 12 AML survivors, treated with chemotherapy, and in 9 survivors of myeloid leukemias treated with ste...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2012.12.008

    authors： Blijdorp K,van Waas M,van der Lely AJ,Pieters R,van den Heuvel-Eibrink M,Neggers S

    更新日期：2013-04-01 00:00:00

  • Prognostic classification of patients with acute lymphoblastic leukemia by using gene copy number profiles identified from array-based comparative genomic hybridization data.

    abstract：:The development of risk-adapted therapy has improved the treatment results of acute lymphoblastic leukemia (ALL) especially in children. However, more accurate risk classifiers are warranted. In this study we aimed at defining a prognostic classifier based on DNA copy number alterations of adolescent and young adult (...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2010.02.031

    authors： Usvasalo A,Elonen E,Saarinen-Pihkala UM,Räty R,Harila-Saari A,Koistinen P,Savolainen ER,Knuutila S,Hollmén J

    更新日期：2010-11-01 00:00:00

  • Increase of DNA damage and alteration of the DNA damage response in myelodysplastic syndromes and acute myeloid leukemias.

    abstract：:Increased DNA damage and alteration of the DNA damage response (DDR) are critical features of genetic instability presumably implicated in pathogenesis of myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML). We used immunofluorescence staining of γH2AX and 53BP1 for analyzing DNA double-strand breaks (DS...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2017.03.011

    authors： Popp HD,Naumann N,Brendel S,Henzler T,Weiss C,Hofmann WK,Fabarius A

    更新日期：2017-06-01 00:00:00

  • Monosomy 7 and Ph-positive acute lymphoblastic leukaemia: cytogenetic and molecular aspects.

    abstract：:A combination of monosomy 7 and translocation t(9;22) (q34;q11), rarely observed in acute lymphoblastic leukaemia (ALL), is here reported: a peculiarity of this case was that the "breakpoint cluster region" on chromosome 22 was not rearranged, as demonstrated by molecular analysis, and a new c-abl protein (p190) was f...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(87)90114-7

    authors： Eridani S,Gorman P,Sheer D,Duncombe AS,Glass UH,Shivji MK

    更新日期：1987-01-01 00:00:00

  • Kappa light chain gene rearrangement in a T-cell lymphoma.

    abstract：:Forty-three patients were studied to determine whether light chain gene rearrangements may occur in hematopoietic cells not pertaining to the B-lineage. In only one patient, affected by T-cell lymphoblastic lymphoma, one kappa light chain allele was rearranged. Neither at the protein level nor at the RNA level the rea...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(91)90145-j

    authors： Moretti L,Mariano MT,Donelli A,Montagnani G,Sarti M,Grantini M,Di Prisco U,Torelli U,Narni F

    更新日期：1991-01-01 00:00:00

  • Intracellular accumulation of cytosine arabinoside in murine normal and neoplastic lymphocytes following their exposure to sodium 2-mercaptoethanesulphonate.

    abstract：:The effect of mesna on intracellular accumulation of cytosine arabinoside (Ara-C) in murine normal and neoplastic lymphocytes was studied. Simultaneous exposure of cells to mesna at concentrations ranging from 0.25 to 1.0 mM and 3H-Ara-C (40.0 nM) resulted in a strong inhibition of Ara-C uptake in normal lymphocytes. ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(93)90117-4

    authors： Jastrzebski Z,Czyzewska-Szafran H,Remiszewska M,Côte-Rozanes C

    更新日期：1993-09-01 00:00:00

  • Aberrant phenotypic expression of CD15 and CD56 identifies poor prognostic acute promyelocytic leukemia patients.

    abstract：:Limited information is available on the relationship between expression of some additional aberrant phenotypic features and outcome of acute promyelocytic leukemia (APL) patients. Here, we set out to assess the frequency of CD15 and CD56 expression, and their prognostic value in a large series of APL patients. One hun...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2013.11.008

    authors： Breccia M,De Propris MS,Minotti C,Stefanizzi C,Raponi S,Colafigli G,Latagliata R,Guarini A,Foà R

    更新日期：2014-02-01 00:00:00

  • Elevated argininosuccinate synthetase activity in adult T leukemia cell lines.

    abstract：:Argininosuccinate synthetase (ASS) is a ATP-dependent and rate-limiting enzyme of the urea cycle which catalyzes L-citrulline to L-arginine in combination with argininosuccinate lyase (ASL). We demonstrate here that (a) human normal T and B lymphocytes did not express ASS activity, (b) however, three adult T leukemia ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(90)90184-b

    authors： Sugimura K,Kimura T,Arakawa H,Ohno T,Wada Y,Kimura Y,Saheki T,Azuma I

    更新日期：1990-01-01 00:00:00

  • Identification of a novel, tissue-specific ABCG2 promoter expressed in pediatric acute megakaryoblastic leukemia.

    abstract：:ABCG2 encodes a transporter protein that is associated with multidrug-resistant phenotypes in many cancers, including acute myeloid leukemia (AML); high levels of expression are generally associated with a poor prognosis. To better understand how expression of ABCG2 is controlled in pediatric AML, we performed a detai...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2011.05.004

    authors： Campbell PK,Zong Y,Yang S,Zhou S,Rubnitz JE,Sorrentino BP

    更新日期：2011-10-01 00:00:00

  • Basis for natural resistance to methotrexate in human acute non-lymphocytic leukemia.

    abstract：:The basis of intrinsic resistance of blasts from patients with acute non-lymphocytic leukemia (ANLL) to methotrexate was studied. MTX polyglutamate formation was measured in blast cells from 19 patients with ANLL and in 7 pediatric patients with acute lymphocytic leukemia (ALL), after in vitro incubation for 24 h with...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(91)90189-z

    authors： Lin JT,Tong WP,Trippett TM,Niedzwiecki D,Tao Y,Tan C,Steinherz P,Schweitzer BI,Bertino JR

    更新日期：1991-01-01 00:00:00

  • Four additional cases of trisomy 14 as the sole anomaly in various haematological malignancies.

    abstract：:We report on four cases of trisomy 14 as the sole anomaly. Three cases were myelodysplastic syndromes and one was a non-Hodgkin's lymphoma. This anomaly is mainly in myeloid disorders and still remains to be well documented. On the other hand, we show this anomaly to be also a non-random anomaly in lymphoproliferative...

    journal_title：Leukemia research

    pub_type： 杂志文章,评审

    doi：10.1016/0145-2126(92)90181-6

    authors： Brizard A,Guilhot F,Babin P,Burucoa C,Tanzer J,Huret JL

    更新日期：1992-01-01 00:00:00

  • Myelodysplastic syndromes in patients under 50 years old: a single institution experience.

    abstract：:We report on our experience relating to 62 patients with myelodysplastic syndrome (MDS) aged less than 50 years, seen at our Institution and conservatively treated from July 1983 to December 2000. Patients demographics and clinical features at diagnosis were analysed for their prognostic value on survival and on risk ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.01.003

    authors： Breccia M,Mengarelli A,Mancini M,Biondo F,Gentilini F,Latagliata R,Mandelli F,Alimena G

    更新日期：2005-07-01 00:00:00

  • Detection of t(14;18) in turkish follicular lymphomas using the polymerase chain reaction.

    abstract：:A t(14;18) translocation is closely associated with the follicular lymphoma but is also seen in diffuse B cell lymphomas with a previous history of a follicular lymphoma as well as de novo diffuse lymphomas. Estimation of the frequency of t(14;18) in follicular lymphoma vary widely from 33 to 89%. Furthermore, no exte...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(00)00009-6

    authors： Sayhan N,Tuzuner N,Aki H,Demir G,Berkarda B

    更新日期：2000-06-01 00:00:00

  • Inhibition of sonic hedgehog signaling blocks cell migration and growth but induces apoptosis via suppression of FOXQ1 in natural killer/T-cell lymphoma.

    abstract：:The present study explored the effects of Forkhead box Q1 (FOXQ1) on cell proliferation, cell cycle and apoptosis via the Sonic hedgehog (Shh) pathway in Natural killer/T-cell lymphoma (NKTCL). Quantitative real time-polymerase chain reaction (qRT-PCR) was performed to detect FOXQ1 expression in 117 NKTCL patients and...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2017.11.001

    authors： Liu P,Chen L

    更新日期：2018-01-01 00:00:00

  • Amsacrine containing induction therapy in elderly AML patients: comparison to standard induction regimens in a matched-pair analysis.

    abstract：:Many elderly patients with newly diagnosed acute myeloid leukemia (AML) present with cardiac comorbidity precluding the use of anthracycline containing chemotherapy regimens. Amsacrine, a topoisomerase II inhibitor, has been proposed as possible alternative to anthracyclines. Here, we report about the combination of a...

    journal_title：Leukemia research

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.leukres.2007.06.015

    authors： Kessler T,Mohr M,Müller-Tidow C,Krug U,Brunnberg U,Mohr B,Schliemann C,Sauerland C,Serve H,Büchner T,Berdel WE,Mesters RM

    更新日期：2008-03-01 00:00:00

  • Differentiation induction in non-lymphocytic leukemia cells upon treatment with mycophenolate mofetil.

    abstract：:Inosine 5'-monophosphate (IMP) dehydrogenase catalyzes the rate-limiting reaction of guanine nucleotide biosynthesis and has been implicated in the reaction of cell growth and differentiation. We investigated the ability of mycophenolate mofetil, a prodrug of mycophenolic acid, to induce differentiation in HL-60 and U...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(00)00045-x

    authors： Inai K,Tsutani H,Yamauchi T,Fukushima T,Iwasaki H,Imamura S,Wano Y,Nemoto Y,Naiki H,Ueda T

    更新日期：2000-09-01 00:00:00

  • Expression of IL-18 and its receptor in human leukemia cells.

    abstract：:The importance of IL-18, although clearly established in solid tumors, has not been fully elucidated in human hematopoietic neoplasms. Here we examined the mRNA and protein for IL-18 in eight human hematopoietic cell lines representing different lineages and neoplasms including leukemia, lymphoma and others. Our resul...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(03)00005-5

    authors： Zhang B,Ma XT,Zheng GG,Li G,Rao Q,Wu KF

    更新日期：2003-09-01 00:00:00

  • Ricin fusion toxin targeted to the human granulocyte-macrophage colony stimulating factor receptor is selectively toxic to acute myeloid leukemia cells.

    abstract：:Treatment failure of patients with acute myelogenous leukemia (AML) is frequently due to the development of multidrug resistance phenotype blasts. We have expressed a fusion protein consisting of human granulocyte-macrophage colony stimulating factor (GMCSF) fused to the N-terminus of a lectin-deficient ricin toxin B ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(97)00043-x

    authors： Burbage C,Tagge EP,Harris B,Hall P,Fu T,Willingham MC,Frankel AE

    更新日期：1997-07-01 00:00:00

  • Combined stratification of refractory anemia according to both WHO and IPSS criteria has a prognostic impact and improves identification of patients who may benefit from stem cell transplantation.

    abstract：:A retrospective analysis of the relationship between the initial classification according to either FAB or WHO criteria, the presence of risk factors and the type of therapy including stem cell transplantation (SCT) on the survival was performed in a group of 106 patients with primary myelodysplastic syndrome (MDS) of...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2003.10.016

    authors： Cermák J,Vítek A,Michalová K

    更新日期：2004-06-01 00:00:00

  • Karyotype at diagnosis, subsequent leukemic transformation and survival in myelodysplastic syndrome. Czechoslovak MDS Cooperative Group.

    abstract：:240 patients with MDS studied cytogenetically at diagnosis between 1981 and 1990 were followed until death or until April 1992 to evaluate the prognostic significance of FAB classification, age and karyotype. 61 patients (25.4%) subsequently transformed into AML and 176 (73.3%) died during the follow-up period. Patien...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(94)00131-s

    authors： Musilová J,Michalová K,Zemanová Z,Neuwirthová R,Dohnalová A

    更新日期：1995-05-01 00:00:00

  • Reversine triggers mitotic catastrophe and apoptosis in K562 cells.

    abstract：:Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm of the hematopoietic stem cell characterized by presence of the oncoprotein BCR-ABL1, which have constitutive tyrosine kinase activity. BCR-ABL1 activation induces aurora kinase A (AURKA) and aurora kinase B (AURKB) expression, which are serine-thr...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2016.06.011

    authors： Rodrigues Alves AP,Machado-Neto JA,Scheucher PS,Paiva HH,Simões BP,Rego EM,Traina F

    更新日期：2016-09-01 00:00:00