ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type.

abstract：BACKGROUND:Telomerase disfunction leads to short telometric overhangs, potentially resulting in chromosome instability. AIMS:To better understand the role of overhang length in the progression of myelodysplastic syndrome (MDS). METHODS:Bone marrow samples of 62 Chinese MDS patients were screened for TERT and TERC gen...

journal_title：Leukemia research

authors： Yan S,Han B,Li H,Wu Y,Zhou D,Zhao Y

更新日期：2013-10-01 00:00:00

abstract：:To increase our knowledge of the pathogenesis of tumour recurrence, cell membrane phenotypes were determined on bone marrow and extramedullary tumour cells at diagnosis and at relapse in 24 children with lymphoid malignancies. There were 19 patients with acute lymphoblastic leukemia and five with non-Hodgkin's lymphom...

journal_title：Leukemia research

authors： Lauer S,Piaskowski V,Camitta B,Casper J

更新日期：1982-01-01 00:00:00

abstract：:Magnetic resonance provides a non-invasive tool for monitoring normal and leukemic bone marrow. Measurements of the T1 relaxation times are elevated in acute myelogenous leukemia. However, interpatient variability diminishes the usefulness of MR measurements for diagnosing leukemia. In following the time course of ind...

journal_title：Leukemia research

authors： Henkelman RM,Messner H,Poon PY,Hinks RS,Stewart C,Curtis J,Minden M,Baker M

更新日期：1988-01-01 00:00:00

abstract：:We describe here a unique case of therapy-related myelodysplastic syndrome (t-MDS) with inv(16)(p13q22) after autologous stem cell transplantation for lymphoma. The rare and smallest I type CBFbeta/MYH11 fusion transcript with a breakpoint at nucleotide 399 of CBFbeta and at nucleotide 2134 of MYH11 was detected in th...

journal_title：Leukemia research

authors： Yamamoto K,Nishikawa S,Minagawa K,Yakushijin K,Okamura A,Matsui T

更新日期：2006-03-01 00:00:00

abstract：:Stromal cells from pediatric myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) associated with MDS (MDS-AML) present high expression of leukemia inhibitor factor (LIF). We demonstrated using mitogen-activated protein kinase (MAPK) inhibitors that in stromal cells from pediatric MDS and MDS-AML, p38MAPK ...

journal_title：Leukemia research

authors： da Costa SV,Roela RA,Junqueira MS,Arantes C,Brentani MM

更新日期：2010-04-01 00:00:00

abstract：:In this study we investigated the Ara-CTP-forming capacity of leukemic cells in different phases of the cell cycle. Cells from two leukemic cell lines and leukemic bone marrow cells from patients and rats (BNML model) with acute myelocytic leukemia were separated according to cell cycle phase by means of an albumin de...

journal_title：Leukemia research

authors： Richel DJ,Colly LP,Arentsen-Honders MW,Starrenburg CW,Willemze R

更新日期：1990-01-01 00:00:00

abstract：:Pyothorax-associated lymphoma (PAL) is a representative form of diffuse large B-cell lymphoma associated with chronic inflammation, in which the Epstein-Barr virus (EBV) genome is consistently detectable in the lymphoma cells of all PAL cases. Cell lines and animal models would be useful for understanding better this ...

journal_title：Leukemia research

authors： Taniguchi A,Hashida Y,Nemoto Y,Taguchi T,Iwahara Y,Daibata M

更新日期：2013-11-01 00:00:00

abstract：:The effect of serum on the proliferation of human bone marrow pluripotent progenitor cells (CFU-GEMM), was compared to that of fresh frozen plasma (FFP). Serum significantly increased the number of mixed erythroid-granulocytic-megakaryocytic colonies (CFU-GEMM) and erythrocytic bursts (BFU-E) in this assay system (p l...

journal_title：Leukemia research

authors： Michalevicz R,Francis GE,Price GM,Hoffbrand AV

更新日期：1985-01-01 00:00:00

abstract：:A novel bivalent single chain fusion protein, Bic3, was assembled consisting of the catalytic and translocation domains of diphtheria toxin (DT(390)) fused to two repeating sFv molecules recognizing human CD3 epsilon of the human T-cell receptor. Historically, problems with these constructs include low yield, toxicity...

journal_title：Leukemia research

authors： Vallera DA,Todhunter D,Kuroki DW,Shu Y,Sicheneder A,Panoskaltsis-Mortari A,Vallera VD,Chen H

更新日期：2005-03-01 00:00:00

abstract：:Cytogenetic analysis provides important diagnostic and prognostic information for patients with myelodysplastic syndromes (MDS). Prior studies, mostly comprised of small sample sizes, have reported conflicting results while evaluating the usefulness of FISH in addition to G-band karyotyping in MDS. In the current stud...

journal_title：Leukemia research

authors： Yang W,Stotler B,Sevilla DW,Emmons FN,Murty VV,Alobeid B,Bhagat G

更新日期：2010-04-01 00:00:00

abstract：:The aim of this study was to evaluate effect of c-KIT mutations on RUNX1/RUNX1T1 fusion transcript expression in patients with t(8;21)-positive AML. Fifty patients diagnosed with t(8;21)-positive AML for recent 10 years were enrolled. Patients with c-KIT mutations tended to achieve a greater than 3-log reduction in RU...

journal_title：Leukemia research

authors： Park SH,Chi HS,Cho YU,Jang S,Park CJ

更新日期：2013-07-01 00:00:00

abstract：:Although the earliest sites of hematopoietic cell and endothelial cell differentiation in the yolk sac blood islands were identified about 100 years ago, cells with hemangioblast properties have not yet been identified in vivo. Endothelial cells differentiate from angioblasts in the embryo and from endothelial progeni...

journal_title：Leukemia research

authors： Ribatti D

更新日期：2007-04-01 00:00:00

abstract：:The capacity of human thymocytes and of differentiated lymphocytes circulating in peripheral blood to perform unscheduled DNA synthesis (a measure of nucleotide excision repair) after UV irradiation was measured by radioautographic analysis. Only 4% of immature T lymphocytes, but 68% of circulating lymphocytes exhibit...

journal_title：Leukemia research

authors： Gensler HL,Lindberg RE,Pinnas JL,Jones JF

更新日期：1985-01-01 00:00:00

abstract：:While MDS was only recently viewed as an orphan disease without any FDA approved therapeutic options, the landscape has changed dramatically with a promise for development of exciting new therapeutics that parallels our growing understanding of the pathobiology of the disease. An array of new agents is entering clinic...

journal_title：Leukemia research

authors： List AF

更新日期：2012-12-01 00:00:00

abstract：:A nonsteroidal anti-inflammatory drug (NSAID)--indomethacin (IN), was found to induce apoptosis and inhibit proliferation of K562 cells and primary culture bone marrow cells from six chronic myelogenous leukemia (CML) patients. IN induced cells apoptosis and inhibited cells proliferation in a dose-and time-dependent m...

journal_title：Leukemia research

authors： Zhang G,Tu C,Zhang G,Zhou G,Zheng W

更新日期：2000-05-01 00:00:00

abstract：:Microtubular reorganisation contributing to apoptotic morphology occurs in normal and neoplastic cells undergoing apoptosis induced by cytotoxic drugs [1-3]. The aim of this study was to correlate the changes in the microtubules (MTs) with behavior of the centrosome in apoptotic cells, and to see whether post-translat...

journal_title：Leukemia research

authors： Pittman S,Geyp M,Fraser M,Ellem K,Peaston A,Ireland C

更新日期：1997-06-01 00:00:00

abstract：:To characterize the molecular mechanisms involved in the transition from the chronic phase to blast crisis in chronic myelogenous leukemia (CML), gene expression profiles of leukemic cells from patients in the chronic and blast crisis phases were analyzed using an 8.7K cDNA chip and real-time PCR. A transient transfec...

journal_title：Leukemia research

authors： Kim KI,Park J,Ahn KS,Won NH,Kim BK,Shin WG,Yoon SS,Oh JM

更新日期：2010-08-01 00:00:00

abstract：:This study was conducted to determine the frequency of the most common fusion genes in Mexican pediatric patients with acute lymphoblastic leukemia (ALL). Molecular analysis using RT-PCR was carried out in 53-blood samples: 52 patients with de novo ALL and one with relapsed ALL. The ETV6-RUNX1 fusion was found in 7 ca...

journal_title：Leukemia research

authors： Jiménez-Morales S,Miranda-Peralta E,Saldaña-Alvarez Y,Perez-Vera P,Paredes-Aguilera R,Rivera-Luna R,Velázquez-Cruz R,Ramírez-Bello J,Carnevale A,Orozco L

更新日期：2008-10-01 00:00:00

abstract：:The use of low density lipoprotein (LDL) as drug carrier in acute myeloblastic leukemia chemotherapy is attractive due to high LDL uptake by leukemic cells. Lipid-based formulations, such as liposomes or microemulsions are promising alternatives. In the current study, we incorporated N-trifluoroacetyl-adriamycin-14-va...

journal_title：Leukemia research

authors： Masquelier M,Lundberg B,Peterson C,Vitols S

更新日期：2006-02-01 00:00:00

abstract：:We report the establishment and characterization, including HLA-typing, immunophenotypic and molecular cytogenetic analysis, of a novel EBV-negative cell line (BLUE-1) derived from adult relapsed sporadic Burkitt lymphoma. BLUE-1 carries the pathognomonic t(8;14)(q24;q32) effecting MYC/IgHJ fusion and a novel t(6;20)(...

journal_title：Leukemia research

authors： Burmeister T,Macleod RA,Reinhardt R,Mansmann V,Loddenkemper C,Marinets O,Drexler HG,Thiel E,Blau IW

更新日期：2006-11-01 00:00:00

abstract：:The concurrent development of chronic myeloid (CML) or myelomonocytic (CMML) leukemia in patients with systemic mastocytosis (SM) is a well recognized phenomenon. Although the leukemia often resembles CML in morphological and in clinical terms, a Ph-Chromosome-positive variant has not been reported in SM so far. We he...

journal_title：Leukemia research

authors： Agis H,Sotlar K,Valent P,Horny HP

更新日期：2005-10-01 00:00:00

abstract：:To improve the recovery rate of high-risk patients with acute promyelocytic leukemia (APL), we used all-trans retinoic acid (ATRA)/arsenic trioxide (ATO)/daunorubicin combination in remission induction, daunorubicin and cytarabine in consolidation, and ATRA/ATO/methotrexate ± 6-mercaptopurine in maintenance treatment ...

journal_title：Leukemia research

authors： Huang H,Qin Y,Xu R,You X,Teng R,Yang L,Xu M,Liu H

更新日期：2012-07-01 00:00:00

abstract：:The K562 leukemia cell line has been extensively used in studies of erythroid differentiation but it has been less well appreciated that treatment of K562 cells with the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) leads to loss of their erythroid properties and to acquisition of several megakaryoblastoi...

journal_title：Leukemia research

authors： Alitalo R

更新日期：1990-01-01 00:00:00

abstract：:We described the clinical features and outcomes for 63 adult patients with acute myeloid leukemia (AML) with a translocation involving the 11q23 locus (MLL) who were treated at Memorial Sloan Kettering Cancer Center (MSK). The population included 40 female (63 %) and 23 male (37 %) patients, with a median age of 51 ye...

journal_title：Leukemia research

authors： Menghrajani K,Zhang Y,Famulare C,Devlin SM,Tallman MS

更新日期：2020-11-01 00:00:00

abstract：:Dose reductions or interruptions may be required to manage treatment-associated adverse events among patients with myelodysplastic syndromes (MDS) treated with lenalidomide; such modifications are recommended to sustain therapy and maximize treatment duration. The aim of this retrospective case-control study was to de...

journal_title：Leukemia research

authors： DeZern AE,Binder G,Ni Q,McGuire M,Smith BD

更新日期：2017-12-01 00:00:00

abstract：:To further understand the role of XIAP in acute myeloid leukemia (AML), we suppressed XIAP expression by antisense oligonucleotides and determined the effect on gene expression profiles and biological pathways. XIAP inhibition upregulated expression of proteasome genes in a manner similar to the proteasome inhibitor b...

journal_title：Leukemia research

authors： Carter BZ,Mak DH,Wang Z,Ma W,Mak PY,Andreeff M,Davis RE

更新日期：2013-08-01 00:00:00

abstract：:Screening for loss of heterozygosity (LOH) of the panel of 18 highly polymorphic microsatellite markers, especially from the region 11p15, was carried out on 154 samples from 26 patients with acute myeloid leukemia and eight with myelodysplastic syndromes (MDS). LOH was detected at the majority (72%) of the loci teste...

journal_title：Leukemia research

authors： Krsková-Honzátková L,Cermák J,Sajdová J,Starý J,Sedlácek P,Sieglová Z

更新日期：2001-01-01 00:00:00

abstract：:We report on four cases of trisomy 14 as the sole anomaly. Three cases were myelodysplastic syndromes and one was a non-Hodgkin's lymphoma. This anomaly is mainly in myeloid disorders and still remains to be well documented. On the other hand, we show this anomaly to be also a non-random anomaly in lymphoproliferative...

journal_title：Leukemia research

authors： Brizard A,Guilhot F,Babin P,Burucoa C,Tanzer J,Huret JL

更新日期：1992-01-01 00:00:00

abstract：:The effects of prostaglandin (PG)E1, PGD2 and 9-deoxy-delta 9-PGD2 (PGJ2) on the clonogenic growth of six kinds of human leukemic cell lines (K562, KG1, HL60, U937, THP1 and Molt4) and normal human myeloid progenitor cells (CFU-GM) were studied using semisolid agar cultures. While the degree of suppression of leukemic...

journal_title：Leukemia research

authors： Tsao CJ,Ozawa K,Hosoi T,Urabe A,Takaku F

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Growing evidence demonstrates that an increased number of CD68 positive tumor-associated macrophages (TAM) is associated with decreased survival in patients with newly diagnosed classic Hodgkin lymphoma (HL). However, the impact of TAM in relapsed and refractory disease is unknown. DESIGN AND METHODS:To inv...

journal_title：Leukemia research

authors： Casulo C,Arcila M,Bohn OL,Teruya-Feldstein J,Maragulia J,Moskowitz CH

更新日期：2013-09-01 00:00:00