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Effects of c-KIT mutations on expression of the RUNX1/RUNX1T1 fusion transcript in t(8;21)-positive acute myeloid leukemia patients.

Abstract：

:The aim of this study was to evaluate effect of c-KIT mutations on RUNX1/RUNX1T1 fusion transcript expression in patients with t(8;21)-positive AML. Fifty patients diagnosed with t(8;21)-positive AML for recent 10 years were enrolled. Patients with c-KIT mutations tended to achieve a greater than 3-log reduction in RUNX1/RUNX1T1 fusion transcript expression less frequently than patients without mutations from 6 to 12 months of follow-up. They have difficulties to obtain molecular complete remission and experience molecular relapse more frequently and rapidly than those without mutations. These results support poor prognostic impact of c-KIT mutations in t(8;21)-positive AML.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Park SH,Chi HS,Cho YU,Jang S,Park CJ

doi

10.1016/j.leukres.2013.02.010

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

784-9

issue

7

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(13)00048-9

journal_volume

37

pub_type

杂志文章

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