当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > Near-tetraploid poorly differentiated acute myeloid leukemia M0 diagnosed by short-term cultures with a phorbol ester TPA.

Near-tetraploid poorly differentiated acute myeloid leukemia M0 diagnosed by short-term cultures with a phorbol ester TPA.

Abstract：

:Leukemic blasts of two patients with acute leukemia exhibited similar characteristics. They were heterogeneous in size with a diameter of 14-30 microns in smears and unclassifiable by morphological, cytochemical, immunophenotypic and ultrastructural examinations. Cytogenetic examinations of both revealed a near-tetraploid karyotype. Blasts from both patients differentiated into macrophages in cultures with 10 ng/ml 12-O-tetradecanoylphorbol-13-acetate (TPA) which is a feature specific for myeloid blasts and the cases were thus classified as poorly differentiated acute myeloid leukemias (AML M0). Near-tetraploid poorly differentiated acute myeloid leukemias M0 seem to be a special category of AML in the morphologic, immunologic and cytogenetic (MIC) classification. The presence of very large blasts in the heterogeneous blast population in acute unclassified leukemias could be a morphological sign of near-tetraploid leukemias AML M0.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Lemez P,Jelínek J,Michalová K,Koubek K,Schwarz J,Malasková V,Rypácková B,Jirásek A,Brezinová J,Hrabánek J

doi

10.1016/0145-2126(94)90087-6

subject

Has Abstract,Author List Incomplete

pub_date

1994-07-01 00:00:00

pages

493-7

issue

7

eissn

0145-2126

issn

1873-5835

journal_volume

18

pub_type

杂志文章

相关文献

LEUKEMIA RESEARCH文献大全
  • The role of p38 mitogen-activated protein kinase in serum-induced leukemia inhibitory factor secretion by bone marrow stromal cells from pediatric myelodysplastic syndromes.

    abstract：:Stromal cells from pediatric myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) associated with MDS (MDS-AML) present high expression of leukemia inhibitor factor (LIF). We demonstrated using mitogen-activated protein kinase (MAPK) inhibitors that in stromal cells from pediatric MDS and MDS-AML, p38MAPK ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2009.10.012

    authors： da Costa SV,Roela RA,Junqueira MS,Arantes C,Brentani MM

    更新日期：2010-04-01 00:00:00

  • Genotypic and cytogenetic study of acute myelocytic leukemia and chronic myelocytic leukemia in blast crisis: specific delta rearrangement pattern does not involve J delta gene locus.

    abstract：:We have analysed the configuration of immunoassociated genes and the karyotypes of 30 patients with acute myelocytic leukemia (AML) and 10 with chronic myelocytic leukemia in blast crisis (CML-BC). In AML, the frequencies of T-cell receptor (TcR) beta, gamma, and delta chain and immunoglobulin heavy and light chain ge...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(91)90070-a

    authors： Akiyoshi TT,Kimura N,Uike N,Kozuru M,Tamura K,Takihara Y,Hisano S,Nishimura J,Kikuchi M

    更新日期：1991-01-01 00:00:00

  • Treatment of pediatric myelodysplastic syndromes and juvenile myelomonocytic leukemia: the Brazilian experience in the past decade.

    abstract：BACKGROUND:Therapy strategies for myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) vary considerably. OBJECTIVE:To review the treatment of Brazilian children who were diagnosed with MDS or JMML in the past decade and reported to the Brazilian Cooperative Group on Pediatric Myelodysplastic Sy...

    journal_title：Leukemia research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.leukres.2004.01.008

    authors： Valera ET,Latorre Mdo R,Mendes WL,Seber A,Lee ML,de Paula MJ,Loggetto SR,Velloso E,Niero-Melo L,Lopes LF,Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes.

    更新日期：2004-09-01 00:00:00

  • Mixed myelodysplastic and myeloproliferative syndromes.

    abstract：:Aplastic anemia, myelodysplastic syndromes (MDS) and chronic myeloproliferative diseases (MPD) are stem cell disorders. There is no clear-cut demarcation of them. Hypoplastic MDS displays features of aplastic anemia and MDS, on the other side mixed myelodysplastic and myeloproliferative syndromes (MDS-MPS) develop. In...

    journal_title：Leukemia research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/0145-2126(96)00028-8

    authors： Neuwirtová R,Mociková K,Musilová J,Jelínek J,Havlícek F,Michalová K,Adamkov M

    更新日期：1996-09-01 00:00:00

  • Development of a mantle cell lymphoma in an ATM heterozygous woman after occupational exposure to ionising radiation and somatic mutation of the second allele.

    abstract：:Predisposition to lymphomagenesis is a well-known phenomenon of ataxia-telangiectasia, a recessive disorder caused by germline inactivation of ATM. ATM encodes a protein implicated in the repair of radiation induced double-strand breaks. Biallelic ATM inactivation was described also in sporadic lymphoid malignancies, ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.11.010

    authors： Briani C,Schlotter M,Lichter P,Kalla C

    更新日期：2006-09-01 00:00:00

  • Indomethacin induces apoptosis and inhibits proliferation in chronic myeloid leukemia cells.

    abstract：:A nonsteroidal anti-inflammatory drug (NSAID)--indomethacin (IN), was found to induce apoptosis and inhibit proliferation of K562 cells and primary culture bone marrow cells from six chronic myelogenous leukemia (CML) patients. IN induced cells apoptosis and inhibited cells proliferation in a dose-and time-dependent m...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(99)00198-8

    authors： Zhang G,Tu C,Zhang G,Zhou G,Zheng W

    更新日期：2000-05-01 00:00:00

  • The clinical characteristics and prognosis of IGH deletion in multiple myeloma.

    abstract：OBJECTIVE:To analyze the frequency, clinical characteristics, and prognosis of IGH deletion in multiple myeloma (MM). METHODS:A total of 310 consecutive patients with multiple myeloma were analyzed. Among them 251 patients were newly diagnosed and 59 patients were previously treated, fluorescence in situ hybridization...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2015.02.010

    authors： He H,Fu W,Jiang H,Du J,Zhou L,Zhang C,Xi H,Li R,Hou J

    更新日期：2015-05-01 00:00:00

  • Predictive factors of response and survival among chronic myelomonocytic leukemia patients treated with azacitidine.

    abstract：:Treatment of CMML remains a clinical challenge, with no drug demonstrating clear clinical benefit. Even if azacitidine is approved in the treatment of CMML, its role remains disputed. We report a cohort of 76 CMML patients (according to WHO classification) treated with azacitidine in 3 programs (French AZA compassiona...

    journal_title：Leukemia research

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.leukres.2013.01.004

    authors： Adès L,Sekeres MA,Wolfromm A,Teichman ML,Tiu RV,Itzykson R,Maciejewski JP,Dreyfus F,List AF,Fenaux P,Komrokji RS

    更新日期：2013-06-01 00:00:00

  • Incidence of haematological malignancies in French Polynesia between 1990 and 1995.

    abstract：:To determine the incidence of haematological malignancies in French Polynesia from 1990 to 1995, we collected cases from the local cancer registry, sanitary evacuation files and all the histopathology and clinical biology laboratories. All leukaemias, non Hodgkin's lymphomas, and multiple myelomas incidence was slight...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(98)00186-6

    authors： Roda L,de Vathaire F,Rio B,Le Tourneau A,Petididier P,Laudon F,Zittoun R

    更新日期：1999-04-01 00:00:00

  • Regulation of topoisomerase II expression during the VM-26 induced differentiation of IW32 murine erythroleukemia cells.

    abstract：:The effect of VM-26, a topoisomerase II targeting drug, on IW32 murine erythroleukemia cells was investigated. The VM-26 induced IW32 cells to differentiate at a non-toxic but cytostatic concentration (0.01 microgram/ml). More than 40% of the cells were induced to synthesize hemoglobin, and cells were arrested in G2/M...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(95)00144-1

    authors： Tan SK,Tang SJ,Wang MC,Hwang J,Wang FF

    更新日期：1996-03-01 00:00:00

  • Circulating myeloid dendritic cell directly isolated from patients with chronic myelogenous leukemia are functional and carry the bcr-abl translocation.

    abstract：:Leukemic bcr-abl positive dendritic cells (DCs) are likely to be present in vivo in chronic myelogenous leukemia (CML) patients, but no data are available on their functional qualities. We analyzed the circulating BDCA-1+ myeloid DC compartment in 15 chronic phase CML patients. Phenotypic features of CML DCs were comp...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.11.028

    authors： Orsini E,Calabrese E,Maggio R,Pasquale A,Nanni M,Trasarti S,Tafuri A,Guarini A,Foa R

    更新日期：2006-07-01 00:00:00

  • Bone marrow niche in the myelodysplastic syndromes.

    abstract：:The myelodysplastic syndromes (MDS) are a diverse group of clonal hematopoietic malignancies characterized by ineffective hematopoiesis, progressive bone marrow (BM) failure, cytogenetic and molecular abnormalities, and variable risk of progression to acute myeloid leukemia (AML). The BM microenvironment in MDS plays ...

    journal_title：Leukemia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.leukres.2015.06.017

    authors： Cogle CR,Saki N,Khodadi E,Li J,Shahjahani M,Azizidoost S

    更新日期：2015-10-01 00:00:00

  • The need for improved neutropenia risk assessment in DLBCL patients receiving R-CHOP-21: findings from clinical practice.

    abstract：:Febrile neutropenia (FN) risk-assessment and granulocyte-colony stimulating factor (G-CSF) prophylaxis use in clinical practice was evaluated in patients with diffuse large B-cell lymphoma receiving R-CHOP-21. More G-CSF primary prophylaxis was used in patients assessed as high FN risk, but R-CHOP-21 was associated wi...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2012.02.002

    authors： Salar A,Haioun C,Rossi FG,Duehrsen U,Pettengell R,Johnsen HE,Jaeger U,Verhoef G,Schwenkglenks M,Bacon P,Bendall K,Lugtenburg PJ

    更新日期：2012-05-01 00:00:00

  • Fatal hyperleukocytic syndrome in a patient with chronic myelomonocytic leukemia.

    abstract：:A 53-year-old male patient was admitted to our hospital with painful splenomegaly. He was diagnosed as having chronic myelomonocytic leukemia (CMML) with leukocytosis, monocytosis, increased lysozyme concentrations in serum und urine, and lack of the Philadelphia chromosome. The clinical course of the disease was char...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(96)00117-8

    authors： Aul C,Gattermann N,Germing U,Südhoff T,Hollmig KA,Heyll A

    更新日期：1997-03-01 00:00:00

  • Diagnostic criteria for hypocellular acute leukemia: a clinical entity distinct from overt acute leukemia and myelodysplastic syndrome.

    abstract：:In order to establish diagnostic criteria for hypocellular acute leukemia (HL), we have reviewed 32 cases selected on the basis of hypothetical 40% or less cellularity, by focusing on morphology, immunophenotype, karyotype and response to low dose Ara-C (LDAC) regimen and compared them with 40 cases of myelodysplastic...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(95)00136-0

    authors： Nagai K,Kohno T,Chen YX,Tsushima H,Mori H,Nakamura H,Jinnai I,Matsuo T,Kuriyama K,Tomonaga M,Bennett JM

    更新日期：1996-07-01 00:00:00

  • Occupation, hobbies, and acute leukemia in adults.

    abstract：:Occupational and industrial exposures have been implicated in the etiology of leukemia, yet uncertainty remains regarding potential high risk occupations. We examined the associations between self-reported occupations and hobbies and acute leukemia risk using data from 811 cases and 637 controls participating in a cas...

    journal_title：Leukemia research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.leukres.2005.03.002

    authors： Terry PD,Shore DL,Rauscher GH,Sandler DP

    更新日期：2005-10-01 00:00:00

  • The morphological subcategories of acute monocytic leukemia (M5a and M5b) share similar immunophenotypic and cytogenetic features and clinical outcomes.

    abstract：:Acute monocytic leukemia (M5) is a subtype of acute myeloid leukemia (AML) with two distinct morphologic subcategories, M5a and M5b. We compared the immunophenotype, cytogenetics and clinical outcome of AML M5 with non-M5 AML and also compared M5a with M5b. One hundred and twelve M5 (76 M5a, 36 M5b) and 726 non-M5 cas...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2007.06.019

    authors： Villeneuve P,Kim DT,Xu W,Brandwein J,Chang H

    更新日期：2008-02-01 00:00:00

  • Identification of a novel, tissue-specific ABCG2 promoter expressed in pediatric acute megakaryoblastic leukemia.

    abstract：:ABCG2 encodes a transporter protein that is associated with multidrug-resistant phenotypes in many cancers, including acute myeloid leukemia (AML); high levels of expression are generally associated with a poor prognosis. To better understand how expression of ABCG2 is controlled in pediatric AML, we performed a detai...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2011.05.004

    authors： Campbell PK,Zong Y,Yang S,Zhou S,Rubnitz JE,Sorrentino BP

    更新日期：2011-10-01 00:00:00

  • High-dose cytarabine-based consolidation shows superior results for older AML patients with intermediate risk cytogenetics in first complete remission.

    abstract：:We evaluated outcomes in two consecutive groups of AML patients age>60 years in CR after 7+3 induction therapy. Group 1 received consolidation with cytarabine 1.5g/m(2) q12h×6+daunorubicin for two cycles, while group 2 received consolidation with 7+3 followed by mitoxantrone+etoposide. For patients with intermediate-r...

    journal_title：Leukemia research

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.leukres.2013.01.001

    authors： Hassanein M,Atenafu EG,Schuh AC,Yee KW,Minden MD,Schimmer AD,Gupta V,Brandwein JM

    更新日期：2013-05-01 00:00:00

  • Reduced-intensity conditioning therapy with fludarabine, idarubicin, busulfan and cytarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.

    abstract：:We retrospectively analyzed allogenic stem cell transplantation (allo-SCT) outcomes in 82 patients with AML or MDS were conditioned with fludarabine, idarubicin, intravenous-busulfan and cytarabine (FIBA) or busulfan and cyclophosphamide (BuCy). Compared to BuCy regimen, reduced intensity conditioning (RIC) with FIBA ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2013.08.016

    authors： Gao L,Gao L,Gong Y,Zhang C,Chen XH,Zhang X

    更新日期：2013-11-01 00:00:00

  • Phase I trial of low-dose oral Clofarabine in myelodysplastic syndromes patients who have failed frontline therapy.

    abstract：:We investigated protracted low-dose oral Clofarabine for the treatment of myelodysplastic syndromes (MDS). Adults with an International Prognostic Scoring System (IPSS) score of INT-1 or higher who had failed first line therapy were eligible. INT-1 patients had to be transfusion-dependent. We started with oral Clofara...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2015.05.004

    authors： Rudrapatna VK,Morley K,Boucher KM,Pierson AS,Shull CT,Kushner JP,Shami PJ

    更新日期：2015-08-01 00:00:00

  • Functional interleukin-2 receptor on a Tac negative human leukaemia T-cell line.

    abstract：:Cell line PER-423 was derived from the cells of a patient with an immature acute T-lymphoblastic leukaemia and the growth of this human cell line is strictly dependent on interleukin-2 (IL-2). PER-423 cells express the p75 (beta) subunit of the IL-2 receptor (IL-2R beta), while the p55 chain (IL-2R alpha) is not detec...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(93)90141-7

    authors： Kees UR,Ford J,Peroni SE,Ranford PR

    更新日期：1993-01-01 00:00:00

  • Smoking as a contributing factor for development of polycythemia vera and related neoplasms.

    abstract：:Smoking may be associated with accelerated erythropoiesis, leukocytosis and thrombocytosis, which are also hallmarks in patients with polycythemia vera, essential thrombocythemia and early stages of myelofibrosis (MPNs). The JAK-STAT and NF-κB signaling pathways are activated in both smokers and in patients with MPNs....

    journal_title：Leukemia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.leukres.2015.09.002

    authors： Hasselbalch HC

    更新日期：2015-09-09 00:00:00

  • Transfer of the cytidine deaminase cDNA into hematopoietic cells.

    abstract：:In order to investigate whether transfer of the cytidine deaminase (CDD) cDNA would increase chemotherapy resistance to cytosine arabinoside (ara-C) we used a retroviral vector expressing both, neomycin phosphotransferase and the CDD cDNA, to transduce hematopoietic cells from cell lines and from murine bone marrow (B...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(99)00128-9

    authors： Flasshove M,Frings W,Schröder JK,Moritz T,Schütte J,Seeber S

    更新日期：1999-11-01 00:00:00

  • The origin and evolution of the term "clone".

    abstract：:In biology, the term "clone" is most widely used to designate genetically identical cells or organisms that are asexually descended from a common progenitor. The concept of clonality in hematology-oncology has received much attention in recent years, as the advent of next-generation sequencing platforms has provided n...

    journal_title：Leukemia research

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.leukres.2017.03.004

    authors： Steensma DP

    更新日期：2017-06-01 00:00:00

  • Properties of lymphocyte 5'nucleotidase in normal subjects and patients with chronic lymphocytic leukemia.

    abstract：:Heterogeneity for 5'nucleotidase has been demonstrated in chronic lymphocytic leukemia [12]. The enzyme is not detectable in the lymphocytes from the majority of patients with this disorder, but normal and even supranormal levels are found in some cases [17]. In the present studies, the properties of this ecto-nucleot...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(82)90026-1

    authors： Conklyn MJ,Silber R

    更新日期：1982-01-01 00:00:00

  • Combined measurement of plasma cell proliferative and apoptotic index in multiple myeloma defines patients with good and poor prognosis.

    abstract：:We assessed plasma cell proliferation (by propidium iodide index, PC-PI) and apoptosis (by annexin-V index PC-AI) for the estimation of overall survival (OS) in multiple myeloma (MM) patients. 181 patients with newly diagnosed MM were assessed, treated using conventional chemotherapy. The values best discriminating pa...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2010.04.015

    authors： Minarik J,Scudla V,Ordeltova M,Pika T,Bacovsky J,Steinbach M,Kumar V,Van Ness B

    更新日期：2011-01-01 00:00:00

  • Risk and outcomes of second malignant neoplasms in chronic myeloid leukemia survivors.

    abstract：:The risk of second malignant neoplasms (SMN) in chronic myeloid leukemia (CML) survivors remains unclear. We utilized the Surveillance, Epidemiology and End Results 18 (SEER 18) registries to evaluate the risk and subsequent outcomes of SMN in CML survivors. There were 3407 patients included. Of these, 170 (4.99%) dev...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2019.05.004

    authors： Jamy O,Sarmad R,Costa L

    更新日期：2019-07-01 00:00:00

  • Endocrine sequelae and metabolic syndrome in adult long-term survivors of childhood acute myeloid leukemia.

    abstract：:This study focuses on the effect of chemotherapy on endocrinopathies and the metabolic syndrome in adult survivors of childhood acute myeloid leukemia (AML). Endocrine function and metabolic syndrome were evaluated in 12 AML survivors, treated with chemotherapy, and in 9 survivors of myeloid leukemias treated with ste...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2012.12.008

    authors： Blijdorp K,van Waas M,van der Lely AJ,Pieters R,van den Heuvel-Eibrink M,Neggers S

    更新日期：2013-04-01 00:00:00

  • Monosomy 7 and Ph-positive acute lymphoblastic leukaemia: cytogenetic and molecular aspects.

    abstract：:A combination of monosomy 7 and translocation t(9;22) (q34;q11), rarely observed in acute lymphoblastic leukaemia (ALL), is here reported: a peculiarity of this case was that the "breakpoint cluster region" on chromosome 22 was not rearranged, as demonstrated by molecular analysis, and a new c-abl protein (p190) was f...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(87)90114-7

    authors： Eridani S,Gorman P,Sheer D,Duncombe AS,Glass UH,Shivji MK

    更新日期：1987-01-01 00:00:00