当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > Reduced-intensity conditioning therapy with fludarabine, idarubicin, busulfan and cytarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.

Reduced-intensity conditioning therapy with fludarabine, idarubicin, busulfan and cytarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.

Abstract：

:We retrospectively analyzed allogenic stem cell transplantation (allo-SCT) outcomes in 82 patients with AML or MDS were conditioned with fludarabine, idarubicin, intravenous-busulfan and cytarabine (FIBA) or busulfan and cyclophosphamide (BuCy). Compared to BuCy regimen, reduced intensity conditioning (RIC) with FIBA was associated with a lower incidence of severe acute GVHD, lower NRM and a similar relapse rate. There was no significant difference in the 3 year overall survival (OS), but this is possibly due to the limited number of patients. The FIBA regimen is promising to replace BuCy regimen because of better security and similar relapse rate.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Gao L,Gao L,Gong Y,Zhang C,Chen XH,Zhang X

doi

10.1016/j.leukres.2013.08.016

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1482-7

issue

11

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(13)00298-1

journal_volume

37

pub_type

杂志文章

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