Abstract:
:Predisposition to lymphomagenesis is a well-known phenomenon of ataxia-telangiectasia, a recessive disorder caused by germline inactivation of ATM. ATM encodes a protein implicated in the repair of radiation induced double-strand breaks. Biallelic ATM inactivation was described also in sporadic lymphoid malignancies, supporting a role of ATM as a tumour suppressor gene. It is, however, still unclear whether ATM heterozygotes are at higher risk of tumours. We describe an ATM heterozygous patient, who developed a mantle cell lymphoma (MCL) after occupational exposure to ionising radiation and somatic mutation of the second ATM allele supporting the contention that heterozygous germline ATM alterations in combination with irradiation exposure predisposes to sporadic MCL.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Briani C,Schlotter M,Lichter P,Kalla Cdoi
10.1016/j.leukres.2005.11.010keywords:
subject
Has Abstractpub_date
2006-09-01 00:00:00pages
1193-6issue
9eissn
0145-2126issn
1873-5835pii
S0145-2126(05)00434-0journal_volume
30pub_type
杂志文章abstract::Chronic lymphocytic leukemia (CLL) is rare in Asians living in Asia and possibly in US Asians. In contrast, CLL is the most common leukemia in whites. The basis for this ethnic and geographic variation is unknown. We compared average annual age-adjusted incidence rates (AAIR) of CLL diagnosed from 1972 to 1995 among L...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(00)00038-2
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:Analyses suggest MDS patients with higher serum ferritin levels (SF) have inferior overall survival (OS), in one study across MDS subtypes. Multiple analyses suggest those with high SF receiving iron chelation therapy (ICT) have superior OS, but which MDS subtypes benefit from ICT remains undefined. METHODS...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.11.005
更新日期:2018-01-01 00:00:00
abstract::We have utilized the MTT assay to measure the metabolic activity of cells from the bone marrow of 55 patients with acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS) and non-clonal disease. Doubling dilutions of cells were exposed to MTT for 3-4 h. The mean optical density of the formazan produced by each c...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00163-8
更新日期:1996-05-01 00:00:00
abstract::Many patients with multiple myeloma (MM) are elderly (aged >65 years) or unfit, and therefore ineligible for stem-cell transplantation. The novel agents thalidomide, bortezomib, and lenalidomide have shown improved outcomes in these patients. This article discusses the role of continuous therapy in improving patient o...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/S0145-2126(12)70005-X
更新日期:2012-11-01 00:00:00
abstract::In a previous study we reported that a new anthracycline derivative (moflomycin) exhibited a higher antileukemic activity compared to other anthracyclines, such as daunorubicin and doxorubicin. To explain the superior antileukemic effect of moflomycin and to disclose a possible structure-activity relationship, we inve...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00155-7
更新日期:1996-02-01 00:00:00
abstract::Dasatinib was approved for the treatment of chronic phase (CP) chronic myeloid leukemia (CML) patients in first line therapy based on the demonstration of efficacy and safety reported in patients enrolled in clinical trials. We describe a multicentric Italian "real-life" experience of dasatinib used as frontline treat...
journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.leukres.2015.11.008
更新日期:2016-01-01 00:00:00
abstract::We studied differentiation inducing effects of retinoic acid (RA), 1 alpha, 25-dihydroxyvitamin D3 (D3) and interferons (IFNs), alone and in combination, on fresh myeloid leukemic cells from 8 patients. RA not only induced the differentiation of leukemic cells in 5/8 cases, but potentiated differentiation by IFNs eith...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(90)90072-h
更新日期:1990-01-01 00:00:00
abstract::The aim of this study is to detect the biologic and/or prognostic significance of survivin (S) and effector protease receptor 1: EPR-1 (E) expression in acute leukemias (34 ALL and 40 AML) by using RT-PCR. S and E expressions were found in 83.8 and 20.3% of the cases, respectively. S was detected in 90%, 76.5% and E w...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.01.005
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVES:Follicular lymphoma (FL) is generally considered an indolent disorder but a significant subset of patients shows a worse outcome. Aim of this study was to validate the FLIPI score in an independent series of follicular lymphoma patients and to correlate prognostic categories with the period of diagnosis and ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2005.07.006
更新日期:2006-03-01 00:00:00
abstract::Overexpression of the Wilms' tumor gene 1 (WT1) was observed in most leukemia cells. In addition to four major isoforms of WT1, an N-terminally truncated isoforms (sWT1) has been identified. We separately quantified the transcript levels of sWT1 and full-length WT1 (fWT1) in 237 patients with acute myeloid leukemia (A...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2011.01.002
更新日期:2011-05-01 00:00:00
abstract::All-trans retinoic acid (ATRA) or phorbol-12-myristate-13-acetate (PMA) are two representative inducers which induce the differentiation of HL-60 cells to myelocytes and monocytes respectively. Structural modifications of the pentasaccharide core portion of N-glycans on cell surface glycoproteins during differentiatio...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(98)00068-x
更新日期:1998-08-01 00:00:00
abstract::The role of hemin induction of K562 in inositol phospholipid metabolism has not been previously studied. K562 cells were induced to synthesize hemoglobin upon addition of bovine hemin to the culture media. The phospholipid content of K562 was determined before and after the addition of hemin. The results of this study...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(91)90055-x
更新日期:1991-01-01 00:00:00
abstract::A method using avidin-biotin complex (ABC) to detect the presence of the enzyme terminal deoxynucleotidyl transferase (TdT) is described and compared with a proven indirect immunofluorescence method. The material studied consisted of: (1) peripheral blood and bone marrow smears from 17 patients with leukemia (ALL, 8; ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(83)90107-8
更新日期:1983-01-01 00:00:00
abstract::A case of acute monocytic leukemia (AMoL) with t(5;11)(q31;q23) and a case of acute myelomonocytic leukemia (AMMoL) with t(5;11)(q35;q13.1) are reported. The translocation between the long arm of chromosome 11q and that of chromosome 5q with leukemia have been rarely reported. Though breakpoint of both cases were subt...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(99)00033-8
更新日期:1999-07-01 00:00:00
abstract::The impact of genetic aberrations on rituximab-based therapeutic regimens has been intensely studied in chronic lymphocytic leukemia (CLL). According to the current consensus chemoimmunotherapy consisting of rituximab and DNA-damaging drugs is not suitable for patients with TP53 defects. In our study, we focused on CL...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2019.04.015
更新日期:2019-06-01 00:00:00
abstract::A panel of human leukemia cell lines from various lineages (T-cell, pre B- and Non-T/Non-B cell, myelomonocytic and erythroleukemia cell lines) were utilised as model systems of the distant effects of differentiation-inducing activity (DIA) produced by the T-leukemia cell line HUT-102. DIA inhibited cell proliferation...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90108-1
更新日期:1987-01-01 00:00:00
abstract::A prospective case-control study of the aetiologic factors involved in the production of lymphoid malignancies has been conducted within a defined geographical area covering six health districts in the Yorkshire Region. Among the aspects investigated were past medical events, occupations and certain social factors. A ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(84)90016-x
更新日期:1984-01-01 00:00:00
abstract::Acute myeloid leukemia (AML) is frequently treated with induction and consolidation chemotherapy. Consolidation chemotherapy can be delivered on an ambulatory basis, requiring some patients to travel long distances for treatment at specialized centers. We developed a shared care model where patients receive consolidat...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.05.023
更新日期:2017-08-01 00:00:00
abstract::The capacity of human thymocytes and of differentiated lymphocytes circulating in peripheral blood to perform unscheduled DNA synthesis (a measure of nucleotide excision repair) after UV irradiation was measured by radioautographic analysis. Only 4% of immature T lymphocytes, but 68% of circulating lymphocytes exhibit...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(85)90006-2
更新日期:1985-01-01 00:00:00
abstract::In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MD...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.10.012
更新日期:2007-04-01 00:00:00
abstract::Thirty patients with high-risk myelodysplastic syndrome, defined as > 5% bone marrow blasts, were treated with a combination of oral all-trans-retinoic acid (45 mg/m2 daily) and subcutaneous AraC (10 mg/m2) on days 1-14 of each 28-35 day cycle repeated for 2-6 cycles. Complete remission lasting 9, 12, and 15 months wa...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章
doi:10.1016/s0145-2126(99)00095-8
更新日期:1999-09-01 00:00:00
abstract::Although there has been much progress in the treatment of acute lymphoblastic leukemia (ALL), decreased sensitivity to chemotherapy remains a significant issue. Recent studies have shown how interactions with the bone marrow microenvironment can protect ALL cells from chemotherapy and allow for the persistence of the ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.01.030
更新日期:2017-05-01 00:00:00
abstract::The surface marker phenotype of lymphocytes derived from 12 patients with B-CLL was compared to that of lymphocytes from 10 patients with an other monoclonal but clinical benign form of B-cell proliferative disorder termed monoclonal B-cell lymphocytosis of undetermined significance (B-MLUS). A panel of well character...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(89)90028-3
更新日期:1989-01-01 00:00:00
abstract::In a patient affected with chronic lymphocytic leukemia with lymphocyte surface mu and kappa determinants and vacuolated bone marrow plasma cells, the serum contained polymers of a truncated mu chain and normal-sized kappa chains. These light chains were present as monomers and covalent dimers in studies performed und...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(93)90129-9
更新日期:1993-06-01 00:00:00
abstract::We describe a 79-year-old man who had massive pleural effusion and a proliferation of prolymphocytic leukemia cells in the peripheral blood, bone marrow, and pleural effusion fluid. Immunophenotyping of leukemia cells revealed either CD3+CD4+CD8-CD25+ or CD3+CD4+CD8+CD25+. The antibody against human T-cell lymphotropi...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.02.029
更新日期:2007-03-01 00:00:00
abstract:INTRODUCTION:The seven in absentia homolog 2 (SIAH2) protein plays a significant role in human cancer by regulating hypoxia-inducible factor-a (HIF-1α); however, its role in T-cell acute lymphoblastic leukemia (T-ALL) is less clear. METHODS:Immunofluorescence evaluation of SIAH2 protein expression and location were co...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2016.01.013
更新日期:2016-03-01 00:00:00
abstract::The levels of expression of the activation antigen CD98 were studied by mAB CAF7 in 51 newly diagnosed consecutive cases of childhood acute lymphoblastic leukemia aged from 1 to 13 years. The mean follow-up was 8 months. A wide range of CAF7 expression was observed, the highest mean fluorescence intensity exceeding th...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00114-x
更新日期:1996-01-01 00:00:00
abstract::Chronic myeloid leukaemia (CML) patients in chronic phase (CP) are currently treated with a standard dose of imatinib of 400mg/daily. However, once in complete cytogenetic remission (CCR) it is possible that some patients maintain this status with reduced dose of the drug. Here, we describe five cases of CML in late C...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2008.10.024
更新日期:2009-05-01 00:00:00
abstract::We retrospectively evaluated the prognostic significance of polypharmacy and inappropriate medication use among 150 patients >60 years of age receiving induction chemotherapy for acute myelogenous leukemia (AML). After adjustment for age and comorbidity, increased number of medications at diagnosis (≥ 4 versus ≤ 1) wa...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2014.06.018
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:The skin is the common extranasal sites in extranodal natural killer (NK) / T - cell lymphoma, (ENKTL). However, data regarding cutaneous ENKTL are relatively scarce. Thus, we performed a large retrospective study to analyze clinical features and treatment outcomes of cutaneous ENKTL. PATIENTS AND METHODS:S...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2019.106284
更新日期:2020-01-01 00:00:00