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Achievement of complete molecular responses in late chronic phase chronic myeloid leukaemia patients treated with pulsed imatinib while in minimal residual disease.

Abstract：

:Chronic myeloid leukaemia (CML) patients in chronic phase (CP) are currently treated with a standard dose of imatinib of 400mg/daily. However, once in complete cytogenetic remission (CCR) it is possible that some patients maintain this status with reduced dose of the drug. Here, we describe five cases of CML in late CP, which were switched to imatinib while in CCR after interferon alpha (IFN alpha) and reached complete and stable molecular remission with intermittent drug administration at 400mg/every 20 days/month.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Breccia M,Cannella L,Stefanizzi C,Santopietro M,De Cuia R,Diverio D,Alimena G

doi

10.1016/j.leukres.2008.10.024

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

645-8

issue

5

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(08)00481-5

journal_volume

33

pub_type

杂志文章

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