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Sharing post-AML consolidation supportive therapy with local centers reduces patient travel burden without compromising outcomes.

Abstract：

:Acute myeloid leukemia (AML) is frequently treated with induction and consolidation chemotherapy. Consolidation chemotherapy can be delivered on an ambulatory basis, requiring some patients to travel long distances for treatment at specialized centers. We developed a shared care model where patients receive consolidation chemotherapy at a quaternary center, but post-consolidation supportive care at local hospitals. To evaluate the impact of our model on patient travel and outcomes we conducted a retrospective analysis of AML and acute promyelocytic leukemia patients receiving consolidation over four years at our quaternary center. 73 patients received post-consolidation care locally, and 344 at the quaternary center. Gender, age and cytogenetic risk did not significantly differ between groups. Shared care patients saved mean round trip distance of 146.5km±99.6 and time of 96.7min±63.4 compared to travelling to quaternary center. There was no significant difference in overall survival between groups, and no increased hazard of death for shared care patients. 30, 60, and 90day survival from start of consolidation was 98.6%, 97.2%, and 95.9% for shared care and 98.8%, 97.1%, and 95.3% for quaternary center patients. Thus, a model utilizing regional partnerships for AML post-consolidation care reduces travel burden while maintaining safety.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Hershenfeld SA,Maki K,Rothfels L,Murray CS,Nixon S,Schimmer AD,Doherty MC

doi

10.1016/j.leukres.2017.05.023

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

93-96

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(17)30445-9

journal_volume

59

pub_type

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