Abstract:
:The CBFA2 gene on chromosome band 21q22 is one of the most commonly translocated genes in leukemia. As with other translocations, those involving CBFA2 are associated with specific disease phenotypes. Only one of the different translocations involving CBFA2, the t(12;21), has been associated with a non-myeloid lineage. Several different CBFA2 fusion transcripts were expressed in the myeloid 32Dcl3 cell line, and show that unlike the myeloid specific fusion transcripts, the lymphoid specific ETV6/CBFA2 transcript is not compatible with myeloid cell differentiation. It is shown that myeloid cells expressing the ETV6/CBFA2 transcript undergo apoptosis in response to a G-CSF differentiation signal. The molecular differences in the cells we studied are characterized using Western blot analysis to show that t(12;21) expressing cells fail to express the G-CSF receptor.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Dann EJ,Fears S,Arád-Dann H,Nucifora G,Rowley JDdoi
10.1016/s0145-2126(99)00150-2keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
11-7issue
1eissn
0145-2126issn
1873-5835pii
S0145212699001502journal_volume
24pub_type
杂志文章abstract::A novel Philadelphia (Ph1) chromosome positive cell line, designated KYO-1, was established from the peripheral blood of a patient with chronic myelogenous leukemia (CML) in blastic crisis. Although this line had a unique capacity to differentiate spontaneously along the erythroid and monocytoid lineages as evidenced ...
journal_title:Leukemia research
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journal_title:Leukemia research
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更新日期:1994-08-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2014.01.002
更新日期:2014-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.06.019
更新日期:2008-02-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.03.018
更新日期:2007-10-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2012.12.003
更新日期:2013-03-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00114-x
更新日期:1996-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(93)90117-4
更新日期:1993-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.01.005
更新日期:2007-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2003.08.011
更新日期:2004-04-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.08.022
更新日期:2010-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2005.07.015
更新日期:2006-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.leukres.2006.03.026
更新日期:2006-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.11.027
更新日期:2010-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2004.11.006
更新日期:2005-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
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更新日期:2003-04-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Leukemia research
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(94)00134-v
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journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/j.leukres.2012.05.021
更新日期:2012-10-01 00:00:00
abstract::Epstein-Barr virus (EBV) can induce a broad spectrum of hematological diseases, especially in immune deficient patients. We assayed for receptor for EBV (EBVR) using fluoresceinated viral particles on 44 human hematopoietic cell lines derived from patients with T, B, and non-T, non-B acute lymphocytic leukemia (ALL), ...
journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章,评审
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2008-02-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2013-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00