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What is the best salvage therapy for treatment of isolated CNS relapse in elderly patients with imatinib-responsive Ph(+) ALL?

Abstract：

:We report the case of an elderly patient affected by Philadelphia positive Acute Lymphoblastic Leukaemia (Ph(+) ALL) who developed meningeal leukaemia during imatinib monotherapy, despite bone marrow molecular remission. Aggressive central nervous system (CNS)-directed therapy in combination with continued imatinib treatment might be, at the moment, the most effective salvage therapy for imatinib-responsive elderly patients with isolated CNS relapse. In view of the inefficacy of imatinib at preventing meningeal leukaemia for its poor penetration into the CNS, CNS prophylactic therapy should always be an integral part of any imatinib-based treatment strategy for Ph(+) ALL.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Mele G,Pinna S,Melpignano A,Romano A,Brocca MC,Coppi MR,Quarta G

doi

10.1016/j.leukres.2007.03.018

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

1445-7

issue

10

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(07)00108-7

journal_volume

31

pub_type

杂志文章

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