Abstract：
:It is generally accepted that morphologically recognizable bone marrow (BM) cells are derived from progenitor cells committed to a specific line of haematopoietic differentiation [51]. The origin and morphological identity of such progenitor cells is not yet known and the question, whether there is a single pluripotent haematopoietic stem cell (HSC) or a variety of stem cells each with a capacity of self-replication and maintenance is still unresolved [37]. Although progress has been made in segregating [43, 47, 49, 64] various progenitor cells from one another and functional assays [11, 17, 42] have significantly promoted the study of haemopoietic precursor cells, morphological investigations were less rewarding. Even after enrichment, the morphology of haemopoietic stem- and colony-forming cells only remained hypothetical, 'candidate stem cells' [3], because their precursor cell qualities could not be deduced from their morphology, but only retrospectively, and statistically from their function, i.e. in vitro colony-formation or in-vivo haemopoietic reconstitution from an enriched cell suspension [58]. We postulate from our studies on semi-thin sections of undecalcified BM from healthy human fetuses, normal adults and patients with acute myeloid leukaemia (AML) and chronic granulocytic leukaemia (CGL) that the endosteal cells are the precursors of all haematopoietic cells in the bone marrow and are also capable of transformation into either stromal (fibroblast-like cells) or bone-related cells (osteoblasts and osteoclasts).
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Islam Adoi
10.1016/0145-2126(85)90130-4subject
Has Abstractpub_date
1985-01-01 00:00:00pages
1415-32issue
11eissn
0145-2126issn
1873-5835pii
0145-2126(85)90130-4journal_volume
9pub_type
杂志文章,评审abstract：:Limited information is available on the relationship between expression of some additional aberrant phenotypic features and outcome of acute promyelocytic leukemia (APL) patients. Here, we set out to assess the frequency of CD15 and CD56 expression, and their prognostic value in a large series of APL patients. One hun...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2013.11.008
更新日期：2014-02-01 00:00:00
abstract：:Proliferative responses of mononuclear cells in liquid cultures to phytohemagglutinin, a T-cell mitogen, are depressed for a long time after allogeneic marrow transplantation. We examined the role of interleukin-2, a lymphokine important in T-cell mitogenesis, in the impaired phytohemagglutinin responses early after m...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(84)90081-x
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND:The Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are associated with increases in janus kinase 2 (JAK2) signaling, often resulting from the JAK2 V617F mutation. LY2784544 (gandotinib) is a potent, selective, small-molecule inhibitor of JAK2 that has potential dose-dependent selectivit...
journal_title：Leukemia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.leukres.2018.06.014
更新日期：2018-08-01 00:00:00
abstract：:To examine the relationship between viability of acute myelogenous leukemia (AML) blasts in liquid suspension culture and the occurrence of myeloid maturation in culture, total and differential cell counts and viability as determined by trypan blue dye exclusion were followed over 21 days of culture. A significant pos...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(88)90098-7
更新日期：1988-01-01 00:00:00
abstract：:The incidence of B cell chronic lymphocytic leukemia (B-CLL) is lower in Asian countries, including India, when compared with Western countries. The bcl-2 gene rearrangement was restricted to the 5' region and seen in only one of the 20 Indian patients analyzed. The incidence remains similar to that reported from West...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(96)00036-7
更新日期：1996-09-01 00:00:00
abstract：BACKGROUND:Monocyte chemoattractant protein-1 (MCP-1) is a member of the CC chemokines. MCP-1 has been previously shown to have a major role in the migration of monocytes towards human leukemic cells, yet it cannot increase cytotoxic effects of monocytes on human leukemic cells. AIM:To determine levels of MCP-1 in the...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.01.017
更新日期：2006-10-01 00:00:00
abstract：:We analysed the optimal conditions for autologous bone marrow purging using complement binding monoclonal antibodies (mAbs). Twelve mAbs belonging to four clusters (CD9, CD10, CD19, CD24), alone or combined were evaluated by using direct cytotoxicity and clonogenic assays. We observed the following data: (1) optimal c...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90117-2
更新日期：1987-01-01 00:00:00
abstract：:The use of low density lipoprotein (LDL) as drug carrier in acute myeloblastic leukemia chemotherapy is attractive due to high LDL uptake by leukemic cells. Lipid-based formulations, such as liposomes or microemulsions are promising alternatives. In the current study, we incorporated N-trifluoroacetyl-adriamycin-14-va...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.06.012
更新日期：2006-02-01 00:00:00
abstract：:Despite high rates of hematologic and cytogenetic responses to imatinib therapy, the emergence of resistance to imatinib has been recognized as a major problem in the treatment of Ph-positive leukemia. The high frequency of BCR-ABL mutations and amplifications represents the high degree of heterogeneity in patients wi...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2003.10.007
更新日期：2004-05-01 00:00:00
abstract：:Several genetic polymorphisms in the genes coding folate-metabolizing enzymes have been associated with susceptibility to hematology malignancies. We conducted a Korean population-based case-control study to examine the relationship between the polymorphisms of folate-metabolizing enzymes and the risk of AML (acute my...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2008.07.026
更新日期：2009-01-01 00:00:00
abstract：:Discovering genetic predictors of childhood acute lymphoblastic leukemia (ALL) necessitates the evaluation of novel factors including maternal genetic effects, which are a proxy for the intrauterine environment, and robust epidemiologic study designs. Therefore, we evaluated five maternal and offspring xenobiotic meta...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.leukres.2013.01.020
更新日期：2013-05-01 00:00:00
abstract：:Twenty-three patients with acute myelogenous leukemia (AML) in first relapse were treated with high-dose cytosine-arabinoside (Ara-C) and amsacrine or idarubicin. To prime the cells, the patients were given rhGM-CSF. We studied the influence of 48-h infusion of rhGM-CSF on proliferation and Ara-C sensitivity of leukem...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章
doi：10.1016/0145-2126(96)00005-7
更新日期：1996-06-01 00:00:00
abstract：:To evaluate the clinical usefulness of interleukin 2 (IL-2) on myelodysplastic syndromes (MDS), the serum IL-2 level, the effect of IL-2 on the proliferation of blasts, and the cell-mediated cytotoxic effect of IL-2 on blasts were examined in MDS patients. Of 18 patients, 2 patients had an increased serum IL-2 level. ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(93)90058-s
更新日期：1993-02-01 00:00:00
abstract：:A primary mitochondrial defect may be pivotal in the pathogenesis of acquired idiopathic sideroblastic anemia (AISA). The mitochondrial respiratory chain is involved in mitochondrial iron uptake and supply of ferrous iron (Fe2+) for heme synthesis. Mitochondrial DNA (mtDNA) comes into play because several subunits of ...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/s0145-2126(99)00160-5
更新日期：2000-02-01 00:00:00
abstract：:To examine the possibility that ETS family transcription factors, PU.1, SPI-B, ELF-1, ERG-3, ETS-1 and TEL, and homeodomain proteins, HOXA10, HOXC13, MEIS1 and PBX1B, function cooperatively, we investigated their interactions. In luciferase assays, HOXA10 and HOXC13 augmented the activity of PU.1 and SPI-B while dimin...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2008.07.002
更新日期：2009-03-01 00:00:00
abstract：:Aberrant expression of tumor suppressor genes WT 1, RB 1, p53, homozygous deletion of p16 gene and their relationship with expression of oncogenes BCR-ABL, TEL-AML 1, MLL-AF 4, E2A-PBX 1, SIL-TAL 1 were determined in bone marrow samples of children with de novo B-lineage (n=170) and T-lineage (n=25) acute lymphoblasti...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.04.006
更新日期：2005-11-01 00:00:00
abstract：:Little information is available about the risk factors and means to improve the survival rate of acute leukemia in a rare but often fatal complication after liver transplantation (LT). We report the development of AML-M2 in one of the 764 patients who underwent liver transplantation at our center, and review the liter...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.03.035
更新日期：2009-10-01 00:00:00
abstract：:Telomere dysfunction might generate genomic instability leading to the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). We investigated telomere length (TL), telomerase activity (TA) and hTERT, c-myc, mad1, and p53 expression in the bone marrow of patients with MDS (n=109), AML (n=47) ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2013.07.022
更新日期：2013-11-01 00:00:00
abstract：:We have previously reported that serum stem factor (SCF) levels are significantly lower in patients with myelodysplastic syndrome (MDS) than normal controls. We have now studied the effects of adding SCF to cultures of blood mononuclear cells from patients with MDS and normal subjects. Three of 17 patients with MDS sh...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(95)00034-l
更新日期：1995-08-01 00:00:00
abstract：:Patients with FLT3-ITD mutated (FLT3-ITD+) Acute Myeloid Leukemia (AML), have frequently relapsed or refractory disease and FLT3-ITD+ inhibitors have limited efficacy. Rho kinases (ROCK) are constitutively activated by FLT3-ITD+ in AML via PI3 kinase and Rho GTPase. Upon activation by ROCK, LIM kinases (LIMK) inactiva...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2020.106490
更新日期：2020-12-13 00:00:00
abstract：:Despite initial remissions, most patients with Ph chromosome positive (Ph(+)) acute leukemia (AL) become refractory to tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib. This study was designed to determine if targeting the interleukin-3 receptor (IL-3R) with a diphtheria toxin fusion protein (DT(388)IL...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.12.008
更新日期：2010-08-01 00:00:00
abstract：:The inaugural meeting of the International Working Group on MDS cytogenetics convened 22-23 October 2007 in Chicago, IL. Under the sponsorship of the Myelodysplastic Syndromes Foundation, the group was organized to address the substantial need for worldwide standardized cytogenetic testing for MDS in clinical practice...
journal_title：Leukemia research
pub_type： 总体
doi：10.1016/j.leukres.2008.03.009
更新日期：2008-09-01 00:00:00
abstract：:Chemotherapy resistance has been considered as a major problem for multiple myeloma (MM) treatment and bone marrow microenvironment plays a crucial role in the MM progression and chemoresistance. Recent studies reported that bone marrow mesenchymal stem cells derived from MM patients (MM-MSCs) revealed various charact...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2017.07.002
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:The median survival of patients with chronic myelogenous leukemia in myeloid blast crisis (MBC-CML) is poor even for patients treated with tyrosine kinase inhibitors (TKIs). DESIGN AND METHODS:We conducted a dose-escalating study of daunorubicin combined to fixed doses of IM (imatinib mesylate, 600 mg/d) an...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.leukres.2010.11.004
更新日期：2011-06-01 00:00:00
abstract：:In a previous study we reported that a new anthracycline derivative (moflomycin) exhibited a higher antileukemic activity compared to other anthracyclines, such as daunorubicin and doxorubicin. To explain the superior antileukemic effect of moflomycin and to disclose a possible structure-activity relationship, we inve...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(95)00155-7
更新日期：1996-02-01 00:00:00
abstract：:Amsacrine is an acridine derivative that has been extensively evaluated for its antitumor activity in recent years. Amsacrine is active in the treatment of acute leukemias and lymphomas but largely ineffective in solid tumors. In acute myelogenous leukemia, amsacrine is as effective as the two most active drugs, cytar...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章,评审
doi：10.1016/0145-2126(86)90331-0
更新日期：1986-01-01 00:00:00
abstract：:Mantle cell lymphoma (MCL) is an aggressive malignancy and new treatment modalities must be established to increase patient survival time. In the search for new therapeutic targets, reliable and well-characterised in vitro models are essential. In this study, we have characterised three MCL cell lines (SP53, Granta 51...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2004.06.009
更新日期：2005-02-01 00:00:00
abstract：:We report on four cases of trisomy 14 as the sole anomaly. Three cases were myelodysplastic syndromes and one was a non-Hodgkin's lymphoma. This anomaly is mainly in myeloid disorders and still remains to be well documented. On the other hand, we show this anomaly to be also a non-random anomaly in lymphoproliferative...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/0145-2126(92)90181-6
更新日期：1992-01-01 00:00:00
abstract：:The effect of serum on the proliferation of human bone marrow pluripotent progenitor cells (CFU-GEMM), was compared to that of fresh frozen plasma (FFP). Serum significantly increased the number of mixed erythroid-granulocytic-megakaryocytic colonies (CFU-GEMM) and erythrocytic bursts (BFU-E) in this assay system (p l...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(85)90062-1
更新日期：1985-01-01 00:00:00
abstract：:All-trans-retinoic acid (ATRA) has been proven active against a range of malignancies in isolated tissue culture systems and in human clinical trials, but the duration of its effects has been transient. Recent evidence indicates that the basis for the limited duration of ATRA's activity, at least in one form of leukem...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(94)90040-x
更新日期：1994-08-01 00:00:00
