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Cytotoxic effect of a lipophilic alkylating agent after incorporation into low density lipoprotein or emulsions: studies in human leukemic cells.

Abstract：

:The use of low density lipoprotein (LDL) as drug carrier in acute myeloblastic leukemia chemotherapy is attractive due to high LDL uptake by leukemic cells. Lipid-based formulations, such as liposomes or microemulsions are promising alternatives. In the current study, we incorporated N-trifluoroacetyl-adriamycin-14-valerate (AD32), a lipophilic derivative of daunorubicin (DNR), and WB4291, a lipophilic alkylating agent, into LDL or lipid microemulsions and evaluated their cytotoxic activities towards leukemic cell lines using as references DNR and melphalan. The incorporation of AD32 into LDL or emulsion resulted in complexes with poor cytotoxicity. WB4291-LDL and WB4291-emulsion exerted, on the other hand, promising cytotoxic effects towards parental and resistant K562 and HL60 cell lines.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Masquelier M,Lundberg B,Peterson C,Vitols S

doi

10.1016/j.leukres.2005.06.012

keywords:

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

136-44

issue

2

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(05)00228-6

journal_volume

30

pub_type

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