Abstract:
:A diagnosis of myelodysplastic syndrome was made in an 18-year-old patient with Warkany syndrome due to constitutional trisomy 8 mosaicism. The possible causal role of this particular chromosome constitution with respect to myelodysplasia and embryonal childhood tumors is discussed.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Zollino M,Genuardi M,Bajer J,Tornesello A,Mastrangelo S,Zampino G,Mastrangelo R,Neri Gdoi
10.1016/0145-2126(95)00050-xsubject
Has Abstractpub_date
1995-10-01 00:00:00pages
733-6issue
10eissn
0145-2126issn
1873-5835pii
014521269500050Xjournal_volume
19pub_type
杂志文章abstract::Deletion in chromosome 9p involving the CDKN2A locus (9p21.3) is known in many malignancies. To detect this deletion in adolescent ALL patients we used oligo array CGH and studied 54 patients aged 10-25 years. Deletion rate was 25/54 (46%), of these 19/25 (76%) were homozygous. Small deletions (<200 kb) were found in ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2008.01.014
更新日期:2008-08-01 00:00:00
abstract::Many elderly patients with newly diagnosed acute myeloid leukemia (AML) present with cardiac comorbidity precluding the use of anthracycline containing chemotherapy regimens. Amsacrine, a topoisomerase II inhibitor, has been proposed as possible alternative to anthracyclines. Here, we report about the combination of a...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.leukres.2007.06.015
更新日期:2008-03-01 00:00:00
abstract::Information about the expression of some myelomonocytic markers in lymphocytes of patients with B-CLL is scarce. We studied the CD13, CD14, CD11c and CD68 surface antigens in 42 controls and in 38 patients with B-CLL to detect their possible reactivity. Eighty-nine percent of B-CLL expressed very strongly the CD14 ant...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(92)90177-9
更新日期:1992-01-01 00:00:00
abstract::We compared the efficacy and toxicity of BEAM (BCNU, etoposide, cytarabine and melphalan) and BuCyE (busulfan, cyclophosphamide and etoposide), given prior to autologous stem cell transplantation (ASCT), in 65 patients with non-Hodgkin's lymphoma. Of these 65 patients, 43 received BEAM and 22 received BuCyE. Their age...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.leukres.2010.07.016
更新日期:2011-02-01 00:00:00
abstract::In-vitro infection of normal human lymphocytes with HTLV-I (human T-cell lymphotropic retrovirus type I) has been carried out to study the target cell specificity and the kinetics of infection. Cord blood (CBL) and adult peripheral blood lymphocytes (PBL) have been co-cultivated with irradiated HTLV-I donor cells (MT2...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(86)90056-1
更新日期:1986-01-01 00:00:00
abstract::The study was undertaken to elucidate the regulatory roles of GMP reductase (GMPR) and IMP dehydrogenase (IMPDH) on purine interconversion during differentiation. Treatment of HL-60 cells with retinoic acid (1 microM) induced granulocytic differentiation which was accompanied with a 2.4-fold increase in GMPR and 55% d...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(92)90002-o
更新日期:1992-06-01 00:00:00
abstract::Osteopontin (OPN) is a cytokine that contributes substantially to the growth and metastasis in a wide spectrum of malignancies. We report here that OPN gene is transactivated by Tax protein of human T-cell leukemia virus type 1 (HTLV-1). Northern blot showed enhanced OPN gene expression in cells stably expressing Tax....
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.08.028
更新日期:2010-06-01 00:00:00
abstract::We have earlier shown that VP-16 combined with Cyclosporin A (CsA) produces tumor specific immunity to L1210 leukemia in BDF/1 mice [Slater LM, Sweet P, Stupecky M, Reynolds JT. Cyclosporin A/VP-16 produced immunity to L1210 leukemia: the participation of cytotoxic CD(8) T-lymphocytes, Clin Immunol Immunopathol 1995;7...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00105-9
更新日期:2002-02-01 00:00:00
abstract::The expression and release of adhesion molecules by acute myelogenous leukemia (AML) blasts was investigated in vitro. For most patients AML blasts expressed relatively low levels of membrane-bound L-selectin and Intercellular adhesion molecule 1 (ICAM-1), but their soluble forms were detected in the supernatants for ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(98)00156-8
更新日期:1999-02-01 00:00:00
abstract::Twenty-two patients with myelodysplastic syndromes (MDS) were treated with thalidomide plus arsenic trioxide (ATO). Twenty-two MDS patients receiving supportive care were used as controls. The remission was achieved in 4 patients (18.2%) receiving thalidomide/ATO, and none in the control group (p<0.05). Fifteen of 22 ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2011.12.023
更新日期:2012-06-01 00:00:00
abstract::2',5'-oligoadenylate synthetase (OAS) has been implicated in the effects of interferons (INF) and steroid hormones on cell growth and differentiation. We studied the combined effects in vitro of hormones and INF on OAS activity in cells from 10 patients with chronic lymphocytic leukemia. IFN enhanced OAS activity in a...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(89)90163-x
更新日期:1989-01-01 00:00:00
abstract::Adult T-cell leukemia/lymphoma is a distinct clinical entity characterized by a clonal proliferation of malignant T-lymphocytes. The etiologic agent of the disease is a Human T-cell lymphotropic virus type I. It occurs almost exclusively in areas where the virus is endemic; however the disease develops only in the min...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2010.02.011
更新日期:2010-12-01 00:00:00
abstract::Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Although several clinical characteristics can be associated with worse prognosis, more robust biological markers still remains uncovered. SMYD2, a member of SMYD protein family, regulates the activity of several proteins through methylation. I...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2014.01.013
更新日期:2014-04-01 00:00:00
abstract::The ability of A-MuLV to transform bone marrow cells on in vitro culture in agarose is enhanced by inclusion of conditioned media during infection and culture. The conditioned medium of a non-virus producing A-MuLV transformed fibroblast cell line was synergistic with medium from Whitlock-Witte long-term bone marrow c...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(91)90469-a
更新日期:1991-01-01 00:00:00
abstract::The usefulness of a new method to detect B-cell monoclonality named VR, which is a combination of the digestion with restriction enzymes and vectorette PCR, in aspiration biopsy-nucleic acid diagnosis (ABND) of thyroid malignant lymphoma was investigated. ABND was performed in 12 patients in whom malignant lymphoma wa...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.03.019
更新日期:2008-01-01 00:00:00
abstract::The effect of VM-26, a topoisomerase II targeting drug, on IW32 murine erythroleukemia cells was investigated. The VM-26 induced IW32 cells to differentiate at a non-toxic but cytostatic concentration (0.01 microgram/ml). More than 40% of the cells were induced to synthesize hemoglobin, and cells were arrested in G2/M...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00144-1
更新日期:1996-03-01 00:00:00
abstract::Standard chemotherapic approach for MZL is missing. We are presenting our monocenter experience with 2CdA+/-rituximab. Patients received 2CdA, 5mg/m(2), weekly, for 6 weeks. Patients receiving rituximab underwent to antibody administration in association with 2CdA, or after the end of chemotherapy. Global ORR was 89.3...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.leukres.2009.04.003
更新日期:2010-02-01 00:00:00
abstract::MicroRNA (miRNA) is an important regulator of cellular proliferation, differentiation and death. Leukemia-specific signature of miRNAs suggests that epigenetic dysregulation of miRNAs is important for leukemogenesis. We focused on the role of DNA methylation of miR-203 which targets BCR-ABL1 mRNA. The microarray analy...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.07.019
更新日期:2013-10-01 00:00:00
abstract::Flow cytometry is commonly used to establish the diagnosis of chronic lymphocytic leukemia (CLL). A defined combination of antibodies discriminates between normal B cells and CLL cells (coexpression of CD5, CD19, and CD23). The receptor tyrosine-like orphan receptor one (ROR1) is an embryonic glycoprotein involved in ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2011.04.006
更新日期:2011-10-01 00:00:00
abstract::C3H/He mice produce myeloid leukemias after whole body irradiation of 1-3Gy as compared with non-irradiated controls that produce fewer than 1% of leukemia [Radiatiton Research 127 (1991) 146]. Thus, p53-deficient C57BL/6 strain, a malignant lymphoma prone, was crossed back into C3H/He strain. Lethally irradiated wild...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(02)00032-2
更新日期:2002-12-01 00:00:00
abstract::Platelet transfusion refractoriness (PTR) is a major adverse event in the management of acute myeloid leukemia (AML). In a series of 897 adult patients with AML receiving intensive chemotherapy, we identified 41 patients (4.8%) with PTR. PTR was more frequently observed in parous women, patients with extra-medullary d...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.08.015
更新日期:2017-10-01 00:00:00
abstract::The hotspot c.7541_7542delCT NOTCH1 mutation has been proven to have a negative clinical impact in chronic lymphocytic leukemia (CLL). However, an optimal method for its detection has not yet been specified. The aim of our study was to examine the presence of the NOTCH1 mutation in CLL using three commonly used molecu...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.08.001
更新日期:2017-09-01 00:00:00
abstract::The treatment of acute leukemia is still challenging due in part to the development of resistance and relapse. This chemotherapeutics resistance is established by clonal selection of resistant variants of the cancer cells. Recently, a horizontal transfer of chemo-resistance among cancer cells via extracellular vesicle...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.09.014
更新日期:2017-11-01 00:00:00
abstract::As a part of our continuing efforts to develop gene therapy for acute myelogenous leukemia (AML), this study was undertaken to evaluate the possibility of using autologous bone marrow stromal fibroblasts (BMSFs) as a target cell population. Autologous BMSFs in AML were isolated from the stromal layers of long-term bon...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00134-5
更新日期:2002-04-01 00:00:00
abstract::Thrombohaemorrhagic complications are major clinical problems in the classical chronic Ph-negative myeloproliferative disorders (CMPDs), polycytaemia vera (PV), essential thrombocythaemia (ET) and idiopathic myelofibrosis (IMF), contributing significantly to morbidity and mortality. Pathophysiologically these disorder...
journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/j.leukres.2005.12.018
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Current results regarding treatment outcomes in acute myeloid leukemia (AML) point to significant differences between low- and middle-income countries (LMIC) and high-income countries (HIC). Excluding well-known socioeconomic issues, genetic markers important for prognosis have not been properly incorporated...
journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.leukres.2017.07.005
更新日期:2017-09-01 00:00:00
abstract::In vivo infection by HTLV-I is characterized by the lack of virus expression in the host's infected cells and in most cases it is clinically inapparent. The present study shows that exposure of HTLV-I-infected human T-cells to a maximal non-toxic dose of 3-MC remarkably enhances virus expression. This stimulatory effe...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(93)90098-6
更新日期:1993-05-01 00:00:00
abstract::FLT3 is a receptor tyrosine kinase involved in the survival of hematopoietic stem cells, and mutations of FLT3 have been reported to be of prognostic significance. This is the first study of FLT3 mutations in pediatric non-promyelocytic AML patients that received the same treatment scheme in single institute. FLT3 int...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2004.11.006
更新日期:2005-06-01 00:00:00
abstract::Rhodamine 123 is transported by the transmembrane efflux pump P glycoprotein (Pgp). We used this fluorescent dye to study multidrug resistance (MDR) activity in normal and leukemic CD34+ cells. These immature cells had a high degree of MDR activity. Among leukemic cells, CD34+ leukemias had significantly higher MDR ac...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(93)90159-i
更新日期:1993-12-01 00:00:00
abstract::The ubiquitin-proteasome pathway is implicated in the pathogenesis of many haematologic malignancies, including multiple myeloma. Under conditions of rapid cell turnover and growth rate, proteasomes are returned into circulation. The measurement of their levels or activity could offer a new approach to diagnosis, prog...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2014.05.008
更新日期:2014-08-01 00:00:00